The absolute number of trans-rearrangements between the TCRG and TCRB loci is predictive of lymphoma risk : A severe combined immune deficiency (SCID) murine model

Pilot studies in human populations have demonstrated a correlation between the level of antigen receptor trans-rearrangements and risk (at the population level) of lymphoid malignancy. Irradiation of newborn severe combined immune deficiency mice results in an increased risk of subsequent developmen...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1997-10, Vol.57 (19), p.4408-4413
Hauptverfasser:	LISTA, F, BERTNESS, V, GUIDES, C. J, DANSKA, J. S, KIRSCH, I. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Biological and medical sciences Biomarkers DNA Nucleotidyltransferases - metabolism DNA Repair - genetics Female Gene Rearrangement, beta-Chain T-Cell Antigen Receptor Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor Host-tumor relations. Immunology. Biological markers Lymphoma - etiology Lymphoma - genetics Male Medical sciences Mice Mice, Inbred BALB C Mice, SCID Neoplasms, Radiation-Induced - etiology Neoplasms, Radiation-Induced - genetics Receptors, Antigen, T-Cell - genetics Risk Severe Combined Immunodeficiency - complications Severe Combined Immunodeficiency - genetics Tumors VDJ Recombinases
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