The absolute number of trans-rearrangements between the TCRG and TCRB loci is predictive of lymphoma risk : A severe combined immune deficiency (SCID) murine model
Pilot studies in human populations have demonstrated a correlation between the level of antigen receptor trans-rearrangements and risk (at the population level) of lymphoid malignancy. Irradiation of newborn severe combined immune deficiency mice results in an increased risk of subsequent developmen...
Gespeichert in:
| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 1997-10, Vol.57 (19), p.4408-4413 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4413 |
|---|---|
| container_issue | 19 |
| container_start_page | 4408 |
| container_title | Cancer research (Chicago, Ill.) |
| container_volume | 57 |
| creator | LISTA, F BERTNESS, V GUIDES, C. J DANSKA, J. S KIRSCH, I. R |
| description | Pilot studies in human populations have demonstrated a correlation between the level of antigen receptor trans-rearrangements and risk (at the population level) of lymphoid malignancy. Irradiation of newborn severe combined immune deficiency mice results in an increased risk of subsequent development of thymic lymphoma (100% of mice so irradiated are dead of thymic lymphoma by 20 weeks of age). We, therefore, assayed the occurrence of trans-rearrangements in this well-controlled mouse mutant system and found a 50-100-fold increase in the absolute number of TCRGV-TCRBJ trans-rearrangements compared to unirradiated littermates (and a comparable fold increase over age-matched BALB/c mice) at 2 weeks following irradiation. We also found a marked disproportion in generating trans-rearrangements versus intralocus rearrangements in the severe combined immune deficiency system compared to BALB/c, independent of irradiation. The trans-rearrangements noted were polyclonal in nature. These data, again, suggest that the absolute level of antigen receptor trans-rearrangements may serve as a biomarker of lymphoma risk. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_16393955</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>16393955</sourcerecordid><originalsourceid>FETCH-LOGICAL-h300t-6779eded5e9ae6bbdbd33237abe5d704feb5ac713cf3a82faa254a10c0b7757a3</originalsourceid><addsrcrecordid>eNo9kM1OwzAQhCMEgvLzCEh7QAgOkZw4rhtuEKBUqoQE5Vyt7Q01xE6xE1CfhxcliIrTzmq-mcPsJKNM8Ekqi0LsJiPG2CQVhcwPksMY34ZXZEzsJ_sl51nGilHyvVgRoIpt03cEvneKArQ1dAF9TANhGMQrOfJdBEXdF5GHbsgsqqcpoDe_4gaaVluwEdaBjNWd_aTfkmbj1qvWIQQb3-EKriHSJwUC3TplPRmwzvWewFBttSWvN3DxXM1uL8H1YQDAtYaa42SvxibSyfYeJS_3d4vqIZ0_TmfV9Txdcca6dCxlSYaMoBJprJRRhvOcS1QkjGRFTUqglhnXNcdJXiPmosCMaaakFBL5UXL-17sO7UdPsVs6GzU1DXpq-7jMxrzkpRADeLoFe-XILNfBOgyb5XbVwT_b-hg1NvUwobbxH8snhWR5yX8A856DWg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16393955</pqid></control><display><type>article</type><title>The absolute number of trans-rearrangements between the TCRG and TCRB loci is predictive of lymphoma risk : A severe combined immune deficiency (SCID) murine model</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>American Association for Cancer Research</source><creator>LISTA, F ; BERTNESS, V ; GUIDES, C. J ; DANSKA, J. S ; KIRSCH, I. R</creator><creatorcontrib>LISTA, F ; BERTNESS, V ; GUIDES, C. J ; DANSKA, J. S ; KIRSCH, I. R</creatorcontrib><description>Pilot studies in human populations have demonstrated a correlation between the level of antigen receptor trans-rearrangements and risk (at the population level) of lymphoid malignancy. Irradiation of newborn severe combined immune deficiency mice results in an increased risk of subsequent development of thymic lymphoma (100% of mice so irradiated are dead of thymic lymphoma by 20 weeks of age). We, therefore, assayed the occurrence of trans-rearrangements in this well-controlled mouse mutant system and found a 50-100-fold increase in the absolute number of TCRGV-TCRBJ trans-rearrangements compared to unirradiated littermates (and a comparable fold increase over age-matched BALB/c mice) at 2 weeks following irradiation. We also found a marked disproportion in generating trans-rearrangements versus intralocus rearrangements in the severe combined immune deficiency system compared to BALB/c, independent of irradiation. The trans-rearrangements noted were polyclonal in nature. These data, again, suggest that the absolute level of antigen receptor trans-rearrangements may serve as a biomarker of lymphoma risk.</description><identifier>ISSN: 0008-5472</identifier><identifier>EISSN: 1538-7445</identifier><identifier>PMID: 9331104</identifier><identifier>CODEN: CNREA8</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Animals ; Animals, Newborn ; Biological and medical sciences ; Biomarkers ; DNA Nucleotidyltransferases - metabolism ; DNA Repair - genetics ; Female ; Gene Rearrangement, beta-Chain T-Cell Antigen Receptor ; Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor ; Host-tumor relations. Immunology. Biological markers ; Lymphoma - etiology ; Lymphoma - genetics ; Male ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Mice, SCID ; Neoplasms, Radiation-Induced - etiology ; Neoplasms, Radiation-Induced - genetics ; Receptors, Antigen, T-Cell - genetics ; Risk ; Severe Combined Immunodeficiency - complications ; Severe Combined Immunodeficiency - genetics ; Tumors ; VDJ Recombinases</subject><ispartof>Cancer research (Chicago, Ill.), 1997-10, Vol.57 (19), p.4408-4413</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2847029$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9331104$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LISTA, F</creatorcontrib><creatorcontrib>BERTNESS, V</creatorcontrib><creatorcontrib>GUIDES, C. J</creatorcontrib><creatorcontrib>DANSKA, J. S</creatorcontrib><creatorcontrib>KIRSCH, I. R</creatorcontrib><title>The absolute number of trans-rearrangements between the TCRG and TCRB loci is predictive of lymphoma risk : A severe combined immune deficiency (SCID) murine model</title><title>Cancer research (Chicago, Ill.)</title><addtitle>Cancer Res</addtitle><description>Pilot studies in human populations have demonstrated a correlation between the level of antigen receptor trans-rearrangements and risk (at the population level) of lymphoid malignancy. Irradiation of newborn severe combined immune deficiency mice results in an increased risk of subsequent development of thymic lymphoma (100% of mice so irradiated are dead of thymic lymphoma by 20 weeks of age). We, therefore, assayed the occurrence of trans-rearrangements in this well-controlled mouse mutant system and found a 50-100-fold increase in the absolute number of TCRGV-TCRBJ trans-rearrangements compared to unirradiated littermates (and a comparable fold increase over age-matched BALB/c mice) at 2 weeks following irradiation. We also found a marked disproportion in generating trans-rearrangements versus intralocus rearrangements in the severe combined immune deficiency system compared to BALB/c, independent of irradiation. The trans-rearrangements noted were polyclonal in nature. These data, again, suggest that the absolute level of antigen receptor trans-rearrangements may serve as a biomarker of lymphoma risk.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>DNA Nucleotidyltransferases - metabolism</subject><subject>DNA Repair - genetics</subject><subject>Female</subject><subject>Gene Rearrangement, beta-Chain T-Cell Antigen Receptor</subject><subject>Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor</subject><subject>Host-tumor relations. Immunology. Biological markers</subject><subject>Lymphoma - etiology</subject><subject>Lymphoma - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, SCID</subject><subject>Neoplasms, Radiation-Induced - etiology</subject><subject>Neoplasms, Radiation-Induced - genetics</subject><subject>Receptors, Antigen, T-Cell - genetics</subject><subject>Risk</subject><subject>Severe Combined Immunodeficiency - complications</subject><subject>Severe Combined Immunodeficiency - genetics</subject><subject>Tumors</subject><subject>VDJ Recombinases</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1OwzAQhCMEgvLzCEh7QAgOkZw4rhtuEKBUqoQE5Vyt7Q01xE6xE1CfhxcliIrTzmq-mcPsJKNM8Ekqi0LsJiPG2CQVhcwPksMY34ZXZEzsJ_sl51nGilHyvVgRoIpt03cEvneKArQ1dAF9TANhGMQrOfJdBEXdF5GHbsgsqqcpoDe_4gaaVluwEdaBjNWd_aTfkmbj1qvWIQQb3-EKriHSJwUC3TplPRmwzvWewFBttSWvN3DxXM1uL8H1YQDAtYaa42SvxibSyfYeJS_3d4vqIZ0_TmfV9Txdcca6dCxlSYaMoBJprJRRhvOcS1QkjGRFTUqglhnXNcdJXiPmosCMaaakFBL5UXL-17sO7UdPsVs6GzU1DXpq-7jMxrzkpRADeLoFe-XILNfBOgyb5XbVwT_b-hg1NvUwobbxH8snhWR5yX8A856DWg</recordid><startdate>19971001</startdate><enddate>19971001</enddate><creator>LISTA, F</creator><creator>BERTNESS, V</creator><creator>GUIDES, C. J</creator><creator>DANSKA, J. S</creator><creator>KIRSCH, I. R</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>19971001</creationdate><title>The absolute number of trans-rearrangements between the TCRG and TCRB loci is predictive of lymphoma risk : A severe combined immune deficiency (SCID) murine model</title><author>LISTA, F ; BERTNESS, V ; GUIDES, C. J ; DANSKA, J. S ; KIRSCH, I. R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h300t-6779eded5e9ae6bbdbd33237abe5d704feb5ac713cf3a82faa254a10c0b7757a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>DNA Nucleotidyltransferases - metabolism</topic><topic>DNA Repair - genetics</topic><topic>Female</topic><topic>Gene Rearrangement, beta-Chain T-Cell Antigen Receptor</topic><topic>Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor</topic><topic>Host-tumor relations. Immunology. Biological markers</topic><topic>Lymphoma - etiology</topic><topic>Lymphoma - genetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, SCID</topic><topic>Neoplasms, Radiation-Induced - etiology</topic><topic>Neoplasms, Radiation-Induced - genetics</topic><topic>Receptors, Antigen, T-Cell - genetics</topic><topic>Risk</topic><topic>Severe Combined Immunodeficiency - complications</topic><topic>Severe Combined Immunodeficiency - genetics</topic><topic>Tumors</topic><topic>VDJ Recombinases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LISTA, F</creatorcontrib><creatorcontrib>BERTNESS, V</creatorcontrib><creatorcontrib>GUIDES, C. J</creatorcontrib><creatorcontrib>DANSKA, J. S</creatorcontrib><creatorcontrib>KIRSCH, I. R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Cancer research (Chicago, Ill.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LISTA, F</au><au>BERTNESS, V</au><au>GUIDES, C. J</au><au>DANSKA, J. S</au><au>KIRSCH, I. R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The absolute number of trans-rearrangements between the TCRG and TCRB loci is predictive of lymphoma risk : A severe combined immune deficiency (SCID) murine model</atitle><jtitle>Cancer research (Chicago, Ill.)</jtitle><addtitle>Cancer Res</addtitle><date>1997-10-01</date><risdate>1997</risdate><volume>57</volume><issue>19</issue><spage>4408</spage><epage>4413</epage><pages>4408-4413</pages><issn>0008-5472</issn><eissn>1538-7445</eissn><coden>CNREA8</coden><abstract>Pilot studies in human populations have demonstrated a correlation between the level of antigen receptor trans-rearrangements and risk (at the population level) of lymphoid malignancy. Irradiation of newborn severe combined immune deficiency mice results in an increased risk of subsequent development of thymic lymphoma (100% of mice so irradiated are dead of thymic lymphoma by 20 weeks of age). We, therefore, assayed the occurrence of trans-rearrangements in this well-controlled mouse mutant system and found a 50-100-fold increase in the absolute number of TCRGV-TCRBJ trans-rearrangements compared to unirradiated littermates (and a comparable fold increase over age-matched BALB/c mice) at 2 weeks following irradiation. We also found a marked disproportion in generating trans-rearrangements versus intralocus rearrangements in the severe combined immune deficiency system compared to BALB/c, independent of irradiation. The trans-rearrangements noted were polyclonal in nature. These data, again, suggest that the absolute level of antigen receptor trans-rearrangements may serve as a biomarker of lymphoma risk.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>9331104</pmid><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0008-5472 |
| ispartof | Cancer research (Chicago, Ill.), 1997-10, Vol.57 (19), p.4408-4413 |
| issn | 0008-5472 1538-7445 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_16393955 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; American Association for Cancer Research |
| subjects | Animals Animals, Newborn Biological and medical sciences Biomarkers DNA Nucleotidyltransferases - metabolism DNA Repair - genetics Female Gene Rearrangement, beta-Chain T-Cell Antigen Receptor Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor Host-tumor relations. Immunology. Biological markers Lymphoma - etiology Lymphoma - genetics Male Medical sciences Mice Mice, Inbred BALB C Mice, SCID Neoplasms, Radiation-Induced - etiology Neoplasms, Radiation-Induced - genetics Receptors, Antigen, T-Cell - genetics Risk Severe Combined Immunodeficiency - complications Severe Combined Immunodeficiency - genetics Tumors VDJ Recombinases |
| title | The absolute number of trans-rearrangements between the TCRG and TCRB loci is predictive of lymphoma risk : A severe combined immune deficiency (SCID) murine model |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T10%3A03%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20absolute%20number%20of%20trans-rearrangements%20between%20the%20TCRG%20and%20TCRB%20loci%20is%20predictive%20of%20lymphoma%20risk%20:%20A%20severe%20combined%20immune%20deficiency%20(SCID)%20murine%20model&rft.jtitle=Cancer%20research%20(Chicago,%20Ill.)&rft.au=LISTA,%20F&rft.date=1997-10-01&rft.volume=57&rft.issue=19&rft.spage=4408&rft.epage=4413&rft.pages=4408-4413&rft.issn=0008-5472&rft.eissn=1538-7445&rft.coden=CNREA8&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E16393955%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16393955&rft_id=info:pmid/9331104&rfr_iscdi=true |