Photoaffinity labeling of the brevetoxin receptor on sodium channels in rat brain synaptosomes

Brevetoxin, a neurotoxin isolated from the marine dinoflagellate Ptychodiscus brevis, has been derivatized into a photoaffinity probe by carbodiimide linkage to p-azidobenzoic acid. Rosenthal analysis of a tritiated p-azidobenzoate brevetoxin derivative indicates that specific binding of the toxin o...

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Veröffentlicht in:	Molecular pharmacology 1991-12, Vol.40 (6), p.988-994
Hauptverfasser:	TRAINER, V. L, THOMSEN, W. J, CATTERALL, W. A, BADEN, D. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Labels - metabolism Animals Azides Benzoates Biological and medical sciences brain Brain - metabolism brevetoxin Cell receptors Cell structures and functions channels Chromatography, Gel Chromatography, High Pressure Liquid Electrophoresis, Polyacrylamide Gel Fundamental and applied biological sciences. Psychology Macromolecular Substances Male Marine Toxins - metabolism Miscellaneous Molecular and cellular biology Oxocins photoaffinity labelling Precipitin Tests Rats Rats, Inbred Strains receptors Receptors, Cell Surface - isolation & purification Receptors, Cell Surface - metabolism sodium Sodium Channels - metabolism Sodium Dodecyl Sulfate Spectrophotometry, Ultraviolet synaptosomes Synaptosomes - metabolism Synaptosomes - ultrastructure Tritium
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