Effect of 2',3'-dideoxycytidine on oxidative phosphorylation in the PC12 cell, a neuronal model

Peripheral neuropathy induced by 2',3'-dideoxycytidine (ddC) could result from the previously shown inhibition of mtDNA replication by the action of ddC on the mitochondrial enzyme DNA polymerase gamma. Such inhibition would be expected to impair oxidative phosphorylation, and this was dem...

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Veröffentlicht in:	Biochemical pharmacology 1997-05, Vol.53 (10), p.1485-1492
Hauptverfasser:	KEILBAUGH, S. A, HOBBS, G. A, SIMPSON, M. V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antimetabolites - pharmacology Antiviral agents Biological and medical sciences Cell Division DNA, Mitochondrial - metabolism Drug toxicity and drugs side effects treatment Lactic Acid - biosynthesis Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Models, Biological Neurons - drug effects Neurons - metabolism Oxidative Phosphorylation - drug effects PC12 Cells Pharmacology. Drug treatments Rats Zalcitabine - pharmacology
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