Regulation of tumor necrosis factor (TNF)‐α synthesis and TNF receptors expression in T lymphocytes through the CD2 activation pathway

The involvement of the CD2 (T11) molecule, an alternative activation pathway for T lymphocytes, in the regulation of tumor necrosis factor (TNF)‐α/TNF receptor system in human T lymphocytes has been investigated. It has been found that both TNF‐α synthesis and secretion were induced after incubation...

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Veröffentlicht in:	European journal of immunology 1992-12, Vol.22 (12), p.3155-3160
Hauptverfasser:	Santis, Ana G., Campanero, Miguel R., Alonso, Jose L., Sánchez‐Madrid, Francisco
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Antibodies, Monoclonal - immunology Antigens, Differentiation, T-Lymphocyte - physiology Biological and medical sciences CD2 Antigens Cells, Cultured Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Lymphocyte Activation Lymphokines, interleukins ( function, expression) Receptors, Cell Surface - analysis Receptors, Immunologic - physiology Receptors, Tumor Necrosis Factor Regulatory factors and their cellular receptors T-Lymphocytes - physiology Tetradecanoylphorbol Acetate - pharmacology Tumor Necrosis Factor-alpha - biosynthesis
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