The identification and characterisation of an actin-binding site in α-actinin by mutagenesis

We have shown previously that the N-terminal actin-binding domain of α-actinin retains activity when expressed in E. coli as a fusion protein with glutathione- S-transferase. In the present study we have made a series of N- and C-terminal deletions within this domain and show that an actin-binding s...

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