IκB interacts with the nuclear localization sequences of the subunits of NF-κB: a mechanism for cytoplasmic retention

NF-kappa B is an inducible transcription factor comprised of a 50-kD (p50) and a 65-kD (p65) subunit. Induction of NF-kappa B activity, which is a critical event in many signal transduction pathways, involves release from a cytoplasmic inhibitory protein, I kappa B, followed by translocation of the...

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Veröffentlicht in:	Genes & development 1992-10, Vol.6 (10), p.1899-1913
Hauptverfasser:	BEG, A. A, RUBEN, S. M, SCHEINMAN, R. I, HASKILL, S, ROSEN, C. A, BALDWIN, A. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Base Sequence Biological and medical sciences Biological Transport Cell Nucleus - metabolism Cells, Cultured Chloramphenicol O-Acetyltransferase - genetics Cytoplasm - metabolism DNA-Binding Proteins - metabolism Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology I-kappa B Proteins Molecular and cellular biology Molecular genetics Molecular Sequence Data Mutagenesis NF-kappa B - genetics NF-kappa B - metabolism NF-KappaB Inhibitor alpha Oligodeoxyribonucleotides Plasmids Precipitin Tests Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-rel Recombinant Fusion Proteins - metabolism Transcription Factor RelB Transcription Factors Transcription. Transcription factor. Splicing. Rna processing Transcriptional Activation Transfection
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