Bradycardia Associated with Intravenous Administration of Tacrolimus in a Liver Transplant Recipient
Cardiotoxicity due to tacrolimus is documented infrequently in the medical literature. Sinus bradycardia associated with intravenous tacrolimus occurred in a 15‐year‐old orthotopic liver transplant recipient. The mechanism of this adverse effect is unknown; however, it does not appear to be concentr...
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| Veröffentlicht in: | Pharmacotherapy 1997-11, Vol.17 (6), p.1328-1330 |
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| container_title | Pharmacotherapy |
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| creator | Cox, Toby H. Baillie, G. Mark Baliga, Prabhakar |
| description | Cardiotoxicity due to tacrolimus is documented infrequently in the medical literature. Sinus bradycardia associated with intravenous tacrolimus occurred in a 15‐year‐old orthotopic liver transplant recipient. The mechanism of this adverse effect is unknown; however, it does not appear to be concentration dependent, and in this patient it resolved on changing to oral therapy. Practitioners should be aware that intravenous administration of tacrolimus may be associated with adverse cardiac events including sinus bradycardia. |
| doi_str_mv | 10.1002/j.1875-9114.1997.tb03101.x |
| format | Article |
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Practitioners should be aware that intravenous administration of tacrolimus may be associated with adverse cardiac events including sinus bradycardia.</description><identifier>ISSN: 0277-0008</identifier><identifier>EISSN: 1875-9114</identifier><identifier>DOI: 10.1002/j.1875-9114.1997.tb03101.x</identifier><identifier>PMID: 9399620</identifier><identifier>CODEN: PHPYDQ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Biological and medical sciences ; Blood Pressure - drug effects ; Bradycardia - chemically induced ; Bradycardia - physiopathology ; Drug toxicity and drugs side effects treatment ; Electrocardiography - drug effects ; Female ; Heart Rate - drug effects ; Humans ; Immunosuppressive Agents - administration & dosage ; Immunosuppressive Agents - adverse effects ; Injections, Intravenous ; Liver Transplantation - immunology ; Medical sciences ; Pharmacology. Drug treatments ; Tacrolimus - administration & dosage ; Tacrolimus - adverse effects ; Toxicity: cardiovascular system</subject><ispartof>Pharmacotherapy, 1997-11, Vol.17 (6), p.1328-1330</ispartof><rights>1997 Pharmacotherapy Publications Inc.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4311-7bcd8bfb0eaae55c2bb868ae18c2536a0677f47b4d7565d9f771719ae3dbaa4b3</citedby><cites>FETCH-LOGICAL-c4311-7bcd8bfb0eaae55c2bb868ae18c2536a0677f47b4d7565d9f771719ae3dbaa4b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fj.1875-9114.1997.tb03101.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fj.1875-9114.1997.tb03101.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2085726$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9399620$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cox, Toby H.</creatorcontrib><creatorcontrib>Baillie, G. Mark</creatorcontrib><creatorcontrib>Baliga, Prabhakar</creatorcontrib><title>Bradycardia Associated with Intravenous Administration of Tacrolimus in a Liver Transplant Recipient</title><title>Pharmacotherapy</title><addtitle>Pharmacotherapy</addtitle><description>Cardiotoxicity due to tacrolimus is documented infrequently in the medical literature. Sinus bradycardia associated with intravenous tacrolimus occurred in a 15‐year‐old orthotopic liver transplant recipient. The mechanism of this adverse effect is unknown; however, it does not appear to be concentration dependent, and in this patient it resolved on changing to oral therapy. Practitioners should be aware that intravenous administration of tacrolimus may be associated with adverse cardiac events including sinus bradycardia.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Bradycardia - chemically induced</subject><subject>Bradycardia - physiopathology</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Electrocardiography - drug effects</subject><subject>Female</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Immunosuppressive Agents - administration & dosage</subject><subject>Immunosuppressive Agents - adverse effects</subject><subject>Injections, Intravenous</subject><subject>Liver Transplantation - immunology</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Tacrolimus - administration & dosage</subject><subject>Tacrolimus - adverse effects</subject><subject>Toxicity: cardiovascular system</subject><issn>0277-0008</issn><issn>1875-9114</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkFlr3DAUhUVISSdJf0JAhNA3u1psy-pTJyEbDDSE6bO4Wkw1eJlIniTz7yszZt77pIvOOXf5ELqmJKeEsB-bnNaizCSlRU6lFPmoCaeE5p8naHGUTtGCMCEyQkj9FZ3HuElZWhXsDJ1JLmXFyALZ2wB2byBYD3gZ42A8jM7iDz_-xc_9GODd9cMu4qXtfO9j-hj90OOhwWswYWh9l0TfY8Ar_-4CXgfo47aFfsSvzvitd_14ib400Eb3bX4v0J-H-_XdU7b6_fh8t1xlpuCUZkIbW-tGEwfgytIwreuqBkdrw0peAamEaAqhCyvKqrSyEYIKKsFxqwEKzS_Q90PfbRjedi6OqvPRuDZt49INila8FlyyZPx5MKYLYgyuUdvgOwh7RYmaEKuNmjiqiaOaEKsZsfpM4at5yk53zh6jM9Ok38w6RANtk4AYH482RupSsCrZfh1sH751-_9YQL08LV-nkv8DQlWbHQ</recordid><startdate>199711</startdate><enddate>199711</enddate><creator>Cox, Toby H.</creator><creator>Baillie, G. Mark</creator><creator>Baliga, Prabhakar</creator><general>Blackwell Publishing Ltd</general><general>Pharmacotherapy</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>199711</creationdate><title>Bradycardia Associated with Intravenous Administration of Tacrolimus in a Liver Transplant Recipient</title><author>Cox, Toby H. ; Baillie, G. Mark ; Baliga, Prabhakar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4311-7bcd8bfb0eaae55c2bb868ae18c2536a0677f47b4d7565d9f771719ae3dbaa4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Bradycardia - chemically induced</topic><topic>Bradycardia - physiopathology</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Electrocardiography - drug effects</topic><topic>Female</topic><topic>Heart Rate - drug effects</topic><topic>Humans</topic><topic>Immunosuppressive Agents - administration & dosage</topic><topic>Immunosuppressive Agents - adverse effects</topic><topic>Injections, Intravenous</topic><topic>Liver Transplantation - immunology</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Tacrolimus - administration & dosage</topic><topic>Tacrolimus - adverse effects</topic><topic>Toxicity: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cox, Toby H.</creatorcontrib><creatorcontrib>Baillie, G. Mark</creatorcontrib><creatorcontrib>Baliga, Prabhakar</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cox, Toby H.</au><au>Baillie, G. Mark</au><au>Baliga, Prabhakar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bradycardia Associated with Intravenous Administration of Tacrolimus in a Liver Transplant Recipient</atitle><jtitle>Pharmacotherapy</jtitle><addtitle>Pharmacotherapy</addtitle><date>1997-11</date><risdate>1997</risdate><volume>17</volume><issue>6</issue><spage>1328</spage><epage>1330</epage><pages>1328-1330</pages><issn>0277-0008</issn><eissn>1875-9114</eissn><coden>PHPYDQ</coden><abstract>Cardiotoxicity due to tacrolimus is documented infrequently in the medical literature. Sinus bradycardia associated with intravenous tacrolimus occurred in a 15‐year‐old orthotopic liver transplant recipient. The mechanism of this adverse effect is unknown; however, it does not appear to be concentration dependent, and in this patient it resolved on changing to oral therapy. Practitioners should be aware that intravenous administration of tacrolimus may be associated with adverse cardiac events including sinus bradycardia.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>9399620</pmid><doi>10.1002/j.1875-9114.1997.tb03101.x</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0277-0008 |
| ispartof | Pharmacotherapy, 1997-11, Vol.17 (6), p.1328-1330 |
| issn | 0277-0008 1875-9114 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Biological and medical sciences Blood Pressure - drug effects Bradycardia - chemically induced Bradycardia - physiopathology Drug toxicity and drugs side effects treatment Electrocardiography - drug effects Female Heart Rate - drug effects Humans Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - adverse effects Injections, Intravenous Liver Transplantation - immunology Medical sciences Pharmacology. Drug treatments Tacrolimus - administration & dosage Tacrolimus - adverse effects Toxicity: cardiovascular system |
| title | Bradycardia Associated with Intravenous Administration of Tacrolimus in a Liver Transplant Recipient |
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