Cerebrovascular Injuries Induced by Activation of Platelets and Leukocytes In Vivo and Their Correction by Neurotropin

Cerebrovascular Injuries Induced by Activation of Platelets and Leukocytes In Vivo and Their Correction by Neurotropin

Ischemia-like brain damage was induced in cats by selective injection of 4β-phorbol-12β-myristate-13α-acetate (PMA) into the left carotid artery. PMA-injection provoked significant decreases in platelet and neutrophil counts due to their intravascular aggregation. Platelet and neutrophil aggregates...

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Veröffentlicht in:Japanese journal of pharmacology 1992-01, Vol.60 (1), p.51-54
Hauptverfasser: Gabrielian, Emil S., Akopov, Sergey E., Grigorian, Marina R., Toumasian, Karen S.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
Blood cell
Blood Platelets - drug effects
Blood. Blood coagulation. Reticuloendothelial system
Brain Edema - drug therapy
Carotid Arteries
Cats
Cell Aggregation - drug effects
Cerebrovascular Disorders - drug therapy
Cerebrovascular Disorders - etiology
Cerebrovascular Disorders - physiopathology
Cerebrovascular injury
Injections, Intra-Arterial
Leukocyte Count - drug effects
Medical sciences
Neurotropin
Neutrophils - drug effects
Neutrophils - physiology
Parietal Lobe - drug effects
Parietal Lobe - metabolism
Pharmacology. Drug treatments
Platelet Aggregation - drug effects
Platelet Count
Polysaccharides - pharmacology
Tetradecanoylphorbol Acetate - administration & dosage
Tetradecanoylphorbol Acetate - pharmacology
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Zusammenfassung:Ischemia-like brain damage was induced in cats by selective injection of 4β-phorbol-12β-myristate-13α-acetate (PMA) into the left carotid artery. PMA-injection provoked significant decreases in platelet and neutrophil counts due to their intravascular aggregation. Platelet and neutrophil aggregates caused brain edema with accumulation of sodium fluorescein in the cerebrospinal fluid and ipsi-lateral derangement of the cerebral energy state in the parietal cortex. Neurotropin administration decreased the changes in platelet and neutrophil counts and prevented the developments of both brain edema and cerebral energy failure.
ISSN:0021-5198
1347-3506
DOI:10.1016/S0021-5198(19)32472-2