The 5′ untranslated region of the human cellular glutathione peroxidase gene is indispensable for its expression in COS-7 cells

We studied the expression of the human cellular glutathione peroxidase (GPx) gene, from which a key enzyme containing selenocysteine (Scy) at the active site is produced. Expression of some human GPx gene mutants in COS-7 cells revealed that the 5′ untranslated region (utr) was necessary for express...

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Veröffentlicht in:	FEBS letters 1992-11, Vol.312 (1), p.10-14
Hauptverfasser:	Kurata, Hiroshi, Kamoshita, Keiichi, Kawai, Eiko, Sukenaga, Yoshikazu, Mizutani, Takaharu
Format:	Artikel
Sprache:	eng
Schlagworte:	5′-iodothyronine monodeiodinase 5′-Untranslated region 5′DI Amino Acid Sequence Animals Base Composition base pairs Base Sequence Biological and medical sciences Blotting, Western bps Cell Line cellular glutathione peroxidase dexamethasone dxm Exons FDH formate dehydrogenase Fundamental and applied biological sciences. Psychology Gene Expression Genes Genetic Vectors Glutathione peroxidase Glutathione Peroxidase - genetics GPx Humans Introns Molecular and cellular biology Molecular genetics Molecular Sequence Data Mutagenesis, Site-Directed Nucleic Acid Conformation PHGPx phospholipid hydroperoxide glutathione peroxidase plasma selenoprotein Protein Biosynthesis RNA, Messenger - genetics RNA, Messenger - metabolism Scy Selenium Selenocysteine SeP Site-directed mutagenesis Transfection untranslated region utr
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