Criteria for Selecting PEGylation Sites on Proteins for Higher Thermodynamic and Proteolytic Stability

PEGylation of protein side chains has been used for more than 30 years to enhance the pharmacokinetic properties of protein drugs. However, there are no structure- or sequence-based guidelines for selecting sites that provide optimal PEG-based pharmacokinetic enhancement with minimal losses to biolo...

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Veröffentlicht in:	Journal of the American Chemical Society 2014-12, Vol.136 (50), p.17547-17560
Hauptverfasser:	Lawrence, Paul B, Gavrilov, Yulian, Matthews, Sam S, Langlois, Minnie I, Shental-Bechor, Dalit, Greenblatt, Harry M, Pandey, Brijesh K, Smith, Mason S, Paxman, Ryan, Torgerson, Chad D, Merrell, Jacob P, Ritz, Cameron C, Prigozhin, Maxim B, Levy, Yaakov, Price, Joshua L
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Binding Sites Molecular Sequence Data Polyethylene Glycols - chemistry Protein Conformation Protein Stability Proteins - chemistry Thermodynamics
Online-Zugang:	Volltext
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