Increased IL-22 level in allergic rhinitis significantly correlates with clinical severity
IL-22 regulates various processes and has been linked to diverse effects. However, the importance of IL-22 in the pathogenesis of allergic rhinitis (AR) remains poorly understood. This study sought to evaluate the levels of IL-22 and IL-17A in AR patients and their association with clinical severity...
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| Veröffentlicht in: | American journal of rhinology & allergy 2014-11, Vol.28 (6), p.197-e201 |
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| container_title | American journal of rhinology & allergy |
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| creator | Tang, Jun Xiao, Ping Luo, Xi Bai, Jing Xia, Wentong Chen, Weixiong Li, Jian Yu, Qingqing Shi, Sisi Xu, Yuxia Mou, Zhonglin Wang, Yuejian Li, Huabin |
| description | IL-22 regulates various processes and has been linked to diverse effects. However, the importance of IL-22 in the pathogenesis of allergic rhinitis (AR) remains poorly understood. This study sought to evaluate the levels of IL-22 and IL-17A in AR patients and their association with clinical severity ofN AR.
Thirty-six AR patients and 22 normal controls were enrolled in this study. The frequencies of IL-22(+), IL-17A(+), and IL-9(+) T helper (Th) cells in peripheral blood of AR patients and normal controls were examined by flow cytometry. Serum levels of IL-22 and IL-17A in AR patients and normal controls were determined by ELISA. The clinical relevance of the percentages of IL-22(+) and IL-17A(+) Th cells as well as serum IL-22 and IL-17A levels were evaluated.
The frequencies of IL-22(+) and IL-17A(+) Th cells, but not IL-9(+) Th cells, were significantly increased compared with those in normal controls (p < 0.05). Frequencies of IL-22(+) and IL-17A(+) Th cells in peripheral blood of AR patients significantly correlated with visual analog scale scores of nasal symptoms (nasal congestion and rhinorrhea; p < 0.05). Moreover, the serum levels of IL-22 and IL-17A were significantly increased compared with those in normal controls (p < 0.05) and significantly correlated with the levels of Dermatophagoides pteronyssinus and Dermatophagoides farinae specific IgE in AR patients.
Our findings suggested that IL-22 as well as IL-17A may play an important role in the regulation of Th2-skewed inflammation in AR patients. |
| doi_str_mv | 10.2500/ajra.2014.28.4088 |
| format | Article |
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Thirty-six AR patients and 22 normal controls were enrolled in this study. The frequencies of IL-22(+), IL-17A(+), and IL-9(+) T helper (Th) cells in peripheral blood of AR patients and normal controls were examined by flow cytometry. Serum levels of IL-22 and IL-17A in AR patients and normal controls were determined by ELISA. The clinical relevance of the percentages of IL-22(+) and IL-17A(+) Th cells as well as serum IL-22 and IL-17A levels were evaluated.
The frequencies of IL-22(+) and IL-17A(+) Th cells, but not IL-9(+) Th cells, were significantly increased compared with those in normal controls (p < 0.05). Frequencies of IL-22(+) and IL-17A(+) Th cells in peripheral blood of AR patients significantly correlated with visual analog scale scores of nasal symptoms (nasal congestion and rhinorrhea; p < 0.05). Moreover, the serum levels of IL-22 and IL-17A were significantly increased compared with those in normal controls (p < 0.05) and significantly correlated with the levels of Dermatophagoides pteronyssinus and Dermatophagoides farinae specific IgE in AR patients.
Our findings suggested that IL-22 as well as IL-17A may play an important role in the regulation of Th2-skewed inflammation in AR patients.</description><identifier>ISSN: 1945-8924</identifier><identifier>EISSN: 1945-8932</identifier><identifier>DOI: 10.2500/ajra.2014.28.4088</identifier><identifier>PMID: 25514475</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Animals ; Antigens, Dermatophagoides - immunology ; Dermatophagoides farinae ; Dermatophagoides pteronyssinus ; Disease Progression ; Female ; Humans ; Immunoglobulin E - blood ; Interleukin-17 - genetics ; Interleukin-17 - metabolism ; Interleukin-22 ; Interleukin-9 - metabolism ; Interleukins - genetics ; Interleukins - metabolism ; Lymphocyte Count ; Male ; Middle Aged ; Nasal Obstruction - immunology ; Rhinitis, Allergic - immunology ; T-Lymphocytes, Helper-Inducer - immunology ; Visual Analog Scale ; Young Adult</subject><ispartof>American journal of rhinology & allergy, 2014-11, Vol.28 (6), p.197-e201</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c301t-71c6b0dc3b9de9f6c1600c3383205c7623e1d2a1fb02ab8cfacbd2e31926c1653</citedby><cites>FETCH-LOGICAL-c301t-71c6b0dc3b9de9f6c1600c3383205c7623e1d2a1fb02ab8cfacbd2e31926c1653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25514475$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tang, Jun</creatorcontrib><creatorcontrib>Xiao, Ping</creatorcontrib><creatorcontrib>Luo, Xi</creatorcontrib><creatorcontrib>Bai, Jing</creatorcontrib><creatorcontrib>Xia, Wentong</creatorcontrib><creatorcontrib>Chen, Weixiong</creatorcontrib><creatorcontrib>Li, Jian</creatorcontrib><creatorcontrib>Yu, Qingqing</creatorcontrib><creatorcontrib>Shi, Sisi</creatorcontrib><creatorcontrib>Xu, Yuxia</creatorcontrib><creatorcontrib>Mou, Zhonglin</creatorcontrib><creatorcontrib>Wang, Yuejian</creatorcontrib><creatorcontrib>Li, Huabin</creatorcontrib><title>Increased IL-22 level in allergic rhinitis significantly correlates with clinical severity</title><title>American journal of rhinology & allergy</title><addtitle>Am J Rhinol Allergy</addtitle><description>IL-22 regulates various processes and has been linked to diverse effects. However, the importance of IL-22 in the pathogenesis of allergic rhinitis (AR) remains poorly understood. This study sought to evaluate the levels of IL-22 and IL-17A in AR patients and their association with clinical severity ofN AR.
Thirty-six AR patients and 22 normal controls were enrolled in this study. The frequencies of IL-22(+), IL-17A(+), and IL-9(+) T helper (Th) cells in peripheral blood of AR patients and normal controls were examined by flow cytometry. Serum levels of IL-22 and IL-17A in AR patients and normal controls were determined by ELISA. The clinical relevance of the percentages of IL-22(+) and IL-17A(+) Th cells as well as serum IL-22 and IL-17A levels were evaluated.
The frequencies of IL-22(+) and IL-17A(+) Th cells, but not IL-9(+) Th cells, were significantly increased compared with those in normal controls (p < 0.05). Frequencies of IL-22(+) and IL-17A(+) Th cells in peripheral blood of AR patients significantly correlated with visual analog scale scores of nasal symptoms (nasal congestion and rhinorrhea; p < 0.05). Moreover, the serum levels of IL-22 and IL-17A were significantly increased compared with those in normal controls (p < 0.05) and significantly correlated with the levels of Dermatophagoides pteronyssinus and Dermatophagoides farinae specific IgE in AR patients.
Our findings suggested that IL-22 as well as IL-17A may play an important role in the regulation of Th2-skewed inflammation in AR patients.</description><subject>Adult</subject><subject>Animals</subject><subject>Antigens, Dermatophagoides - immunology</subject><subject>Dermatophagoides farinae</subject><subject>Dermatophagoides pteronyssinus</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin E - blood</subject><subject>Interleukin-17 - genetics</subject><subject>Interleukin-17 - metabolism</subject><subject>Interleukin-22</subject><subject>Interleukin-9 - metabolism</subject><subject>Interleukins - genetics</subject><subject>Interleukins - metabolism</subject><subject>Lymphocyte Count</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nasal Obstruction - immunology</subject><subject>Rhinitis, Allergic - immunology</subject><subject>T-Lymphocytes, Helper-Inducer - immunology</subject><subject>Visual Analog Scale</subject><subject>Young Adult</subject><issn>1945-8924</issn><issn>1945-8932</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kDtPwzAURi0EoqXwA1iQR5YEP_MYUcWjUiUWWFgs5-amdeUmxU5B_fckKnS6dzjfGQ4ht5ylQjP2YDfBpoJxlYoiVawozsiUl0onRSnF-ekXakKuYtwwlimt-CWZCK25Urmeks9FCwFtxJoulokQ1OM3eupaar3HsHJAw9q1rneRRrdqXePAtr0_UOhCQG97jPTH9WsKfsDAehoHQ3D94ZpcNNZHvPm7M_Lx_PQ-f02Wby-L-eMyAcl4n-QcsorVIKuyxrLJgGeMgZSFFExDngmJvBaWNxUTtiqgsVDVAiUvxchqOSP3R-8udF97jL3ZugjovW2x20fDM5mXZaZ4MaD8iELoYgzYmF1wWxsOhjMzJjVjUjMmNaIwY9Jhc_en31dbrE-L_4byF2-Nc2w</recordid><startdate>201411</startdate><enddate>201411</enddate><creator>Tang, Jun</creator><creator>Xiao, Ping</creator><creator>Luo, Xi</creator><creator>Bai, Jing</creator><creator>Xia, Wentong</creator><creator>Chen, Weixiong</creator><creator>Li, Jian</creator><creator>Yu, Qingqing</creator><creator>Shi, Sisi</creator><creator>Xu, Yuxia</creator><creator>Mou, Zhonglin</creator><creator>Wang, Yuejian</creator><creator>Li, Huabin</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201411</creationdate><title>Increased IL-22 level in allergic rhinitis significantly correlates with clinical severity</title><author>Tang, Jun ; Xiao, Ping ; Luo, Xi ; Bai, Jing ; Xia, Wentong ; Chen, Weixiong ; Li, Jian ; Yu, Qingqing ; Shi, Sisi ; Xu, Yuxia ; Mou, Zhonglin ; Wang, Yuejian ; Li, Huabin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c301t-71c6b0dc3b9de9f6c1600c3383205c7623e1d2a1fb02ab8cfacbd2e31926c1653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Animals</topic><topic>Antigens, Dermatophagoides - immunology</topic><topic>Dermatophagoides farinae</topic><topic>Dermatophagoides pteronyssinus</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoglobulin E - blood</topic><topic>Interleukin-17 - genetics</topic><topic>Interleukin-17 - metabolism</topic><topic>Interleukin-22</topic><topic>Interleukin-9 - metabolism</topic><topic>Interleukins - genetics</topic><topic>Interleukins - metabolism</topic><topic>Lymphocyte Count</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nasal Obstruction - immunology</topic><topic>Rhinitis, Allergic - immunology</topic><topic>T-Lymphocytes, Helper-Inducer - immunology</topic><topic>Visual Analog Scale</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tang, Jun</creatorcontrib><creatorcontrib>Xiao, Ping</creatorcontrib><creatorcontrib>Luo, Xi</creatorcontrib><creatorcontrib>Bai, Jing</creatorcontrib><creatorcontrib>Xia, Wentong</creatorcontrib><creatorcontrib>Chen, Weixiong</creatorcontrib><creatorcontrib>Li, Jian</creatorcontrib><creatorcontrib>Yu, Qingqing</creatorcontrib><creatorcontrib>Shi, Sisi</creatorcontrib><creatorcontrib>Xu, Yuxia</creatorcontrib><creatorcontrib>Mou, Zhonglin</creatorcontrib><creatorcontrib>Wang, Yuejian</creatorcontrib><creatorcontrib>Li, Huabin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of rhinology & allergy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tang, Jun</au><au>Xiao, Ping</au><au>Luo, Xi</au><au>Bai, Jing</au><au>Xia, Wentong</au><au>Chen, Weixiong</au><au>Li, Jian</au><au>Yu, Qingqing</au><au>Shi, Sisi</au><au>Xu, Yuxia</au><au>Mou, Zhonglin</au><au>Wang, Yuejian</au><au>Li, Huabin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased IL-22 level in allergic rhinitis significantly correlates with clinical severity</atitle><jtitle>American journal of rhinology & allergy</jtitle><addtitle>Am J Rhinol Allergy</addtitle><date>2014-11</date><risdate>2014</risdate><volume>28</volume><issue>6</issue><spage>197</spage><epage>e201</epage><pages>197-e201</pages><issn>1945-8924</issn><eissn>1945-8932</eissn><abstract>IL-22 regulates various processes and has been linked to diverse effects. However, the importance of IL-22 in the pathogenesis of allergic rhinitis (AR) remains poorly understood. This study sought to evaluate the levels of IL-22 and IL-17A in AR patients and their association with clinical severity ofN AR.
Thirty-six AR patients and 22 normal controls were enrolled in this study. The frequencies of IL-22(+), IL-17A(+), and IL-9(+) T helper (Th) cells in peripheral blood of AR patients and normal controls were examined by flow cytometry. Serum levels of IL-22 and IL-17A in AR patients and normal controls were determined by ELISA. The clinical relevance of the percentages of IL-22(+) and IL-17A(+) Th cells as well as serum IL-22 and IL-17A levels were evaluated.
The frequencies of IL-22(+) and IL-17A(+) Th cells, but not IL-9(+) Th cells, were significantly increased compared with those in normal controls (p < 0.05). Frequencies of IL-22(+) and IL-17A(+) Th cells in peripheral blood of AR patients significantly correlated with visual analog scale scores of nasal symptoms (nasal congestion and rhinorrhea; p < 0.05). Moreover, the serum levels of IL-22 and IL-17A were significantly increased compared with those in normal controls (p < 0.05) and significantly correlated with the levels of Dermatophagoides pteronyssinus and Dermatophagoides farinae specific IgE in AR patients.
Our findings suggested that IL-22 as well as IL-17A may play an important role in the regulation of Th2-skewed inflammation in AR patients.</abstract><cop>United States</cop><pmid>25514475</pmid><doi>10.2500/ajra.2014.28.4088</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 1945-8924 |
| ispartof | American journal of rhinology & allergy, 2014-11, Vol.28 (6), p.197-e201 |
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| language | eng |
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| source | MEDLINE; SAGE Complete; Alma/SFX Local Collection |
| subjects | Adult Animals Antigens, Dermatophagoides - immunology Dermatophagoides farinae Dermatophagoides pteronyssinus Disease Progression Female Humans Immunoglobulin E - blood Interleukin-17 - genetics Interleukin-17 - metabolism Interleukin-22 Interleukin-9 - metabolism Interleukins - genetics Interleukins - metabolism Lymphocyte Count Male Middle Aged Nasal Obstruction - immunology Rhinitis, Allergic - immunology T-Lymphocytes, Helper-Inducer - immunology Visual Analog Scale Young Adult |
| title | Increased IL-22 level in allergic rhinitis significantly correlates with clinical severity |
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