Zymosan induces selective release of arachidonic acid from rabbit alveolar macrophages via stimulation of a β-glucan receptor
Zymosan, which is composed primarily of α-mannan and β-glucan polymers, is a well recognized activator of macrophages. The type receptor by which unopsonized zymosan induces arachidonic acid release was investigated. It was found that particulate β-glucan and zymosan stimulated an identical dose-dep...
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| Veröffentlicht in: | FEBS letters 1992-09, Vol.309 (2), p.119-122 |
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| creator | Daum, Timothy Rohrbach, Michael S. |
| description | Zymosan, which is composed primarily of α-mannan and β-glucan polymers, is a well recognized activator of macrophages. The type receptor by which unopsonized zymosan induces arachidonic acid release was investigated. It was found that particulate β-glucan and zymosan stimulated an identical dose-dependent release of arachidonic acid. This release of arachidonic acid by zymosan was blocked by soluble β-glucans whereas soluble mannan had no effect. This inhibition was not due to a general toxic effect of the soluble β-glucans as they had no effect on calcium ionophore-induced release of arachidonic acid. β-glucan-induced fatty acid release from these cells was shown to be fairly specific for arachidonic acid. These data reveal that zymosan stimulates the specific release of arachidonic acid from rabbit alveolar macrophages, at least in part, via a β-glucan receptor. |
| doi_str_mv | 10.1016/0014-5793(92)81077-Y |
| format | Article |
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The type receptor by which unopsonized zymosan induces arachidonic acid release was investigated. It was found that particulate β-glucan and zymosan stimulated an identical dose-dependent release of arachidonic acid. This release of arachidonic acid by zymosan was blocked by soluble β-glucans whereas soluble mannan had no effect. This inhibition was not due to a general toxic effect of the soluble β-glucans as they had no effect on calcium ionophore-induced release of arachidonic acid. β-glucan-induced fatty acid release from these cells was shown to be fairly specific for arachidonic acid. These data reveal that zymosan stimulates the specific release of arachidonic acid from rabbit alveolar macrophages, at least in part, via a β-glucan receptor.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/0014-5793(92)81077-Y</identifier><identifier>PMID: 1324190</identifier><identifier>CODEN: FEBLAL</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Alveolar macrophage ; Animals ; arachidonic acid ; Arachidonic Acid - metabolism ; beta -glucan ; Biological and medical sciences ; Calcimycin - pharmacology ; Cell physiology ; Dose-Response Relationship, Drug ; Fundamental and applied biological sciences. Psychology ; Glucans - pharmacology ; induction ; macrophages ; Macrophages, Alveolar - drug effects ; Macrophages, Alveolar - metabolism ; Molecular and cellular biology ; Rabbits ; receptors ; Receptors, Cell Surface - physiology ; Receptors, Immunologic ; release ; requirements ; Responses to growth factors, tumor promotors, other factors ; Zymosan ; Zymosan - pharmacology ; α-Mannan ; β-Glucan</subject><ispartof>FEBS letters, 1992-09, Vol.309 (2), p.119-122</ispartof><rights>1992</rights><rights>FEBS Letters 309 (1992) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526Y-fb59907f0b92bfea76396d4db87cd2af47f246f18809bf0d8a0718e31bc51be23</citedby><cites>FETCH-LOGICAL-c526Y-fb59907f0b92bfea76396d4db87cd2af47f246f18809bf0d8a0718e31bc51be23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/001457939281077Y$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5512846$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1324190$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Daum, Timothy</creatorcontrib><creatorcontrib>Rohrbach, Michael S.</creatorcontrib><title>Zymosan induces selective release of arachidonic acid from rabbit alveolar macrophages via stimulation of a β-glucan receptor</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>Zymosan, which is composed primarily of α-mannan and β-glucan polymers, is a well recognized activator of macrophages. The type receptor by which unopsonized zymosan induces arachidonic acid release was investigated. It was found that particulate β-glucan and zymosan stimulated an identical dose-dependent release of arachidonic acid. This release of arachidonic acid by zymosan was blocked by soluble β-glucans whereas soluble mannan had no effect. This inhibition was not due to a general toxic effect of the soluble β-glucans as they had no effect on calcium ionophore-induced release of arachidonic acid. β-glucan-induced fatty acid release from these cells was shown to be fairly specific for arachidonic acid. These data reveal that zymosan stimulates the specific release of arachidonic acid from rabbit alveolar macrophages, at least in part, via a β-glucan receptor.</description><subject>Alveolar macrophage</subject><subject>Animals</subject><subject>arachidonic acid</subject><subject>Arachidonic Acid - metabolism</subject><subject>beta -glucan</subject><subject>Biological and medical sciences</subject><subject>Calcimycin - pharmacology</subject><subject>Cell physiology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucans - pharmacology</subject><subject>induction</subject><subject>macrophages</subject><subject>Macrophages, Alveolar - drug effects</subject><subject>Macrophages, Alveolar - metabolism</subject><subject>Molecular and cellular biology</subject><subject>Rabbits</subject><subject>receptors</subject><subject>Receptors, Cell Surface - physiology</subject><subject>Receptors, Immunologic</subject><subject>release</subject><subject>requirements</subject><subject>Responses to growth factors, tumor promotors, other factors</subject><subject>Zymosan</subject><subject>Zymosan - pharmacology</subject><subject>α-Mannan</subject><subject>β-Glucan</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM-OFCEQxjtGs46rb6AJB2P00Ar0P7hsopsdNdnEix7GC6mGYhdDNyN0j5mLD-WD-EzSM5P1ZjwB9X31FfUriqeMvmaUtW8oZXXZdLJ6KfkrwWjXlZt7xYqJriqruhX3i9Wd5WHxKKVvNL8Fk2fFGat4zSRdFT-_7oeQYCRuNLPGRBJ61JPbIYn5BglJsAQi6Ftnwug0Ae0MsTEMJELfu4mA32HwEMkAOobtLdzkmJ0DkiY3zB4mF8ZDCPn9q7zxs87TImrcTiE-Lh5Y8AmfnM7z4sv66vPlh_L60_uPl2-vS93wdlPavpGSdpb2kvcWoWsr2Zra9KLThoOtO8vr1jIhqOwtNQJoxwRWrNcN65FX58WLY-42hu8zpkkNLmn0HkYMc1KsrTpZS5aN9dGYV0kpolXb6AaIe8WoWrCrhalamCrJ1QG72uS2Z6f8uR_Q_G06cs7685MOSYO3EUbt0p2taRgXdZtt66Pth_O4_6_Ran31ji_CUpf8UF3-c3EMwgx15zCqpB2OGo3L6Cdlgvv3Qn8A9-S1PQ</recordid><startdate>19920907</startdate><enddate>19920907</enddate><creator>Daum, Timothy</creator><creator>Rohrbach, Michael S.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope></search><sort><creationdate>19920907</creationdate><title>Zymosan induces selective release of arachidonic acid from rabbit alveolar macrophages via stimulation of a β-glucan receptor</title><author>Daum, Timothy ; Rohrbach, Michael S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526Y-fb59907f0b92bfea76396d4db87cd2af47f246f18809bf0d8a0718e31bc51be23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Alveolar macrophage</topic><topic>Animals</topic><topic>arachidonic acid</topic><topic>Arachidonic Acid - metabolism</topic><topic>beta -glucan</topic><topic>Biological and medical sciences</topic><topic>Calcimycin - pharmacology</topic><topic>Cell physiology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucans - pharmacology</topic><topic>induction</topic><topic>macrophages</topic><topic>Macrophages, Alveolar - drug effects</topic><topic>Macrophages, Alveolar - metabolism</topic><topic>Molecular and cellular biology</topic><topic>Rabbits</topic><topic>receptors</topic><topic>Receptors, Cell Surface - physiology</topic><topic>Receptors, Immunologic</topic><topic>release</topic><topic>requirements</topic><topic>Responses to growth factors, tumor promotors, other factors</topic><topic>Zymosan</topic><topic>Zymosan - pharmacology</topic><topic>α-Mannan</topic><topic>β-Glucan</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Daum, Timothy</creatorcontrib><creatorcontrib>Rohrbach, Michael S.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Daum, Timothy</au><au>Rohrbach, Michael S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Zymosan induces selective release of arachidonic acid from rabbit alveolar macrophages via stimulation of a β-glucan receptor</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1992-09-07</date><risdate>1992</risdate><volume>309</volume><issue>2</issue><spage>119</spage><epage>122</epage><pages>119-122</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><coden>FEBLAL</coden><abstract>Zymosan, which is composed primarily of α-mannan and β-glucan polymers, is a well recognized activator of macrophages. The type receptor by which unopsonized zymosan induces arachidonic acid release was investigated. It was found that particulate β-glucan and zymosan stimulated an identical dose-dependent release of arachidonic acid. This release of arachidonic acid by zymosan was blocked by soluble β-glucans whereas soluble mannan had no effect. This inhibition was not due to a general toxic effect of the soluble β-glucans as they had no effect on calcium ionophore-induced release of arachidonic acid. β-glucan-induced fatty acid release from these cells was shown to be fairly specific for arachidonic acid. These data reveal that zymosan stimulates the specific release of arachidonic acid from rabbit alveolar macrophages, at least in part, via a β-glucan receptor.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>1324190</pmid><doi>10.1016/0014-5793(92)81077-Y</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Alveolar macrophage Animals arachidonic acid Arachidonic Acid - metabolism beta -glucan Biological and medical sciences Calcimycin - pharmacology Cell physiology Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Glucans - pharmacology induction macrophages Macrophages, Alveolar - drug effects Macrophages, Alveolar - metabolism Molecular and cellular biology Rabbits receptors Receptors, Cell Surface - physiology Receptors, Immunologic release requirements Responses to growth factors, tumor promotors, other factors Zymosan Zymosan - pharmacology α-Mannan β-Glucan |
| title | Zymosan induces selective release of arachidonic acid from rabbit alveolar macrophages via stimulation of a β-glucan receptor |
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