Non-NMDA receptor antagonist GYKI 52466 suppresses cortical afterdischarges in immature rats

GYKI 52466 (1-(4-aminophenyl)-4-methyl-7,8-methylendioxy-5H-2,3-benzo-diazepine), a non-competitive non-NMDA receptor antagonist, was tested against epileptic afterdischarges elicited by cortical stimulation in 12-, 18- and 25-day-old rats with implanted electrodes. Shortening of afterdischarges and...

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Veröffentlicht in:	European journal of pharmacology 1997-08, Vol.333 (1), p.17-26
Hauptverfasser:	KUBOVA, H, VILAGI, I, MIKULECKA, A, MARES, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Anxiety Agents Anticonvulsant action Anticonvulsants. Antiepileptics. Antiparkinson agents Benzodiazepines - pharmacology Biological and medical sciences Cerebral Cortex - drug effects Electric Stimulation Electrodes, Implanted Electroencephalography - drug effects Electrophysiology Epilepsy - physiopathology Epilepsy, Tonic-Clonic - chemically induced Epilepsy, Tonic-Clonic - physiopathology Excitatory Amino Acid Antagonists - pharmacology Excitatory amino acids Female Flumazenil GYKI 52466 Humans Male Medical sciences Motor Skills - drug effects Motor system Neuropharmacology Pharmacology. Drug treatments Postural Balance - drug effects Rats Rats, Wistar Receptors, AMPA - antagonists & inhibitors
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