Effect of antibiotics on the phagocytotic and respiratory burst activity of bovine granulocytes
The influence of antibiotics on respiratory burst (phorbol-12-myristate-13-acetate (PMA)-stimulated luminol-enhanced chemiluminescence) and phagocytosis (flow cytometry) by bovine granulocytes was studied in vitro. Phagocytosis was impaired by 1000 μg/ml of oxytetracycline, chloramphenicol, erythrom...
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| Veröffentlicht in: | European journal of pharmacology 1997-08, Vol.332 (3), p.289-297 |
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| creator | Hoeben, Dagmar Dosogne, Hilde Heyneman, Roger Burvenich, Christian |
| description | The influence of antibiotics on respiratory burst (phorbol-12-myristate-13-acetate (PMA)-stimulated luminol-enhanced chemiluminescence) and phagocytosis (flow cytometry) by bovine granulocytes was studied in vitro. Phagocytosis was impaired by 1000
μg/ml of oxytetracycline, chloramphenicol, erythromycin and spiramycin. All antibiotics, except sulphadiazine, decreased chemiluminescence at 1000
μg/ml or lower concentrations. Enrofloxacin increased chemiluminescence. The inhibition by oxytetracycline and danofloxacin was due to absorption of the light emitted by luminol at 425 nm. Oxytetracycline, ceftiofur, spiramycin and erythromycin affected the myeloperoxidase–H
2O
2–halide system. Ceftiofur, penicillin and danofloxacin showed scavenging effects on H
2O
2 and OCl
-. Penicillin and ceftiofur might interfere with luminol. Chloramphenicol, penicillin and ceftiofur affected the production of superoxide radicals. In summary, the observed effects of antibiotics might be of importance during treatment of infectious diseases in normal and immunocompromised animals. However, before classifying a drug as immunosuppressive, attention has to be paid to possible interference with the chemiluminescence assay. |
| doi_str_mv | 10.1016/S0014-2999(97)01107-2 |
| format | Article |
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μg/ml of oxytetracycline, chloramphenicol, erythromycin and spiramycin. All antibiotics, except sulphadiazine, decreased chemiluminescence at 1000
μg/ml or lower concentrations. Enrofloxacin increased chemiluminescence. The inhibition by oxytetracycline and danofloxacin was due to absorption of the light emitted by luminol at 425 nm. Oxytetracycline, ceftiofur, spiramycin and erythromycin affected the myeloperoxidase–H
2O
2–halide system. Ceftiofur, penicillin and danofloxacin showed scavenging effects on H
2O
2 and OCl
-. Penicillin and ceftiofur might interfere with luminol. Chloramphenicol, penicillin and ceftiofur affected the production of superoxide radicals. In summary, the observed effects of antibiotics might be of importance during treatment of infectious diseases in normal and immunocompromised animals. However, before classifying a drug as immunosuppressive, attention has to be paid to possible interference with the chemiluminescence assay.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/S0014-2999(97)01107-2</identifier><identifier>PMID: 9300263</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Anti-Bacterial Agents - pharmacology ; Antibiotics ; Biological and medical sciences ; Cattle ; Cell Size - drug effects ; Cell Survival - drug effects ; Cell-Free System ; Drug toxicity and drugs side effects treatment ; Female ; Granulocytes - drug effects ; Granulocytes - metabolism ; Luminescent Measurements ; Medical sciences ; Neutrophils - drug effects ; Neutrophils - enzymology ; Peroxidase - blood ; Phagocytosis ; Phagocytosis - drug effects ; Pharmacology. Drug treatments ; Polymorphonuclear leukocytes ; Respiratory burst ; Respiratory Burst - drug effects ; Tetradecanoylphorbol Acetate - pharmacology ; Toxicity: blood</subject><ispartof>European journal of pharmacology, 1997-08, Vol.332 (3), p.289-297</ispartof><rights>1997 Elsevier Science B.V.</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-77dd03438b2730e4be4d5be7e47b70bcf652b14cfcf8e4d417c78196d62740ef3</citedby><cites>FETCH-LOGICAL-c420t-77dd03438b2730e4be4d5be7e47b70bcf652b14cfcf8e4d417c78196d62740ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014299997011072$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2795340$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9300263$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hoeben, Dagmar</creatorcontrib><creatorcontrib>Dosogne, Hilde</creatorcontrib><creatorcontrib>Heyneman, Roger</creatorcontrib><creatorcontrib>Burvenich, Christian</creatorcontrib><title>Effect of antibiotics on the phagocytotic and respiratory burst activity of bovine granulocytes</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>The influence of antibiotics on respiratory burst (phorbol-12-myristate-13-acetate (PMA)-stimulated luminol-enhanced chemiluminescence) and phagocytosis (flow cytometry) by bovine granulocytes was studied in vitro. Phagocytosis was impaired by 1000
μg/ml of oxytetracycline, chloramphenicol, erythromycin and spiramycin. All antibiotics, except sulphadiazine, decreased chemiluminescence at 1000
μg/ml or lower concentrations. Enrofloxacin increased chemiluminescence. The inhibition by oxytetracycline and danofloxacin was due to absorption of the light emitted by luminol at 425 nm. Oxytetracycline, ceftiofur, spiramycin and erythromycin affected the myeloperoxidase–H
2O
2–halide system. Ceftiofur, penicillin and danofloxacin showed scavenging effects on H
2O
2 and OCl
-. Penicillin and ceftiofur might interfere with luminol. Chloramphenicol, penicillin and ceftiofur affected the production of superoxide radicals. In summary, the observed effects of antibiotics might be of importance during treatment of infectious diseases in normal and immunocompromised animals. However, before classifying a drug as immunosuppressive, attention has to be paid to possible interference with the chemiluminescence assay.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotics</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>Cell Size - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Cell-Free System</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Female</subject><subject>Granulocytes - drug effects</subject><subject>Granulocytes - metabolism</subject><subject>Luminescent Measurements</subject><subject>Medical sciences</subject><subject>Neutrophils - drug effects</subject><subject>Neutrophils - enzymology</subject><subject>Peroxidase - blood</subject><subject>Phagocytosis</subject><subject>Phagocytosis - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Polymorphonuclear leukocytes</subject><subject>Respiratory burst</subject><subject>Respiratory Burst - drug effects</subject><subject>Tetradecanoylphorbol Acetate - pharmacology</subject><subject>Toxicity: blood</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFrFDEYhoModVv9CYUcRPQw-iWTmUxOUkqtQsGDeg5J5ksbmZ2sSWZh_72Z7rJXT4G8z_vl4wkh1ww-MWD9558ATDRcKfVByY_AGMiGvyAbNkjVgGT8JdmckdfkMuc_ANAp3l2QC9UC8L7dEH3nPbpCo6dmLsGGWILLNM60PCHdPZnH6A5lvaz5SBPmXUimxHSgdkm5UONK2IdyWCfYuA8z0sdk5mVae5jfkFfeTBnfns4r8vvr3a_bb83Dj_vvtzcPjRMcSiPlOEIr2sFy2QIKi2LsLEoU0kqwzvcdt0w47_xQI8GkkwNT_dhzKQB9e0XeH-fuUvy7YC56G7LDaTIzxiVr1reyb4eugt0RdCnmnNDrXQpbkw6agV7F6mexerWmldTPYjWvvevTA4vd4nhunUzW_N0pN9mZyVcHLuQzxqXqWgEV-3LEsMrYB0w6u4CzwzGk-g96jOE_i_wDgb-WPg</recordid><startdate>19970813</startdate><enddate>19970813</enddate><creator>Hoeben, Dagmar</creator><creator>Dosogne, Hilde</creator><creator>Heyneman, Roger</creator><creator>Burvenich, Christian</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>19970813</creationdate><title>Effect of antibiotics on the phagocytotic and respiratory burst activity of bovine granulocytes</title><author>Hoeben, Dagmar ; Dosogne, Hilde ; Heyneman, Roger ; Burvenich, Christian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-77dd03438b2730e4be4d5be7e47b70bcf652b14cfcf8e4d417c78196d62740ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotics</topic><topic>Biological and medical sciences</topic><topic>Cattle</topic><topic>Cell Size - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Cell-Free System</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Female</topic><topic>Granulocytes - drug effects</topic><topic>Granulocytes - metabolism</topic><topic>Luminescent Measurements</topic><topic>Medical sciences</topic><topic>Neutrophils - drug effects</topic><topic>Neutrophils - enzymology</topic><topic>Peroxidase - blood</topic><topic>Phagocytosis</topic><topic>Phagocytosis - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Polymorphonuclear leukocytes</topic><topic>Respiratory burst</topic><topic>Respiratory Burst - drug effects</topic><topic>Tetradecanoylphorbol Acetate - pharmacology</topic><topic>Toxicity: blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hoeben, Dagmar</creatorcontrib><creatorcontrib>Dosogne, Hilde</creatorcontrib><creatorcontrib>Heyneman, Roger</creatorcontrib><creatorcontrib>Burvenich, Christian</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hoeben, Dagmar</au><au>Dosogne, Hilde</au><au>Heyneman, Roger</au><au>Burvenich, Christian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of antibiotics on the phagocytotic and respiratory burst activity of bovine granulocytes</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1997-08-13</date><risdate>1997</risdate><volume>332</volume><issue>3</issue><spage>289</spage><epage>297</epage><pages>289-297</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>The influence of antibiotics on respiratory burst (phorbol-12-myristate-13-acetate (PMA)-stimulated luminol-enhanced chemiluminescence) and phagocytosis (flow cytometry) by bovine granulocytes was studied in vitro. Phagocytosis was impaired by 1000
μg/ml of oxytetracycline, chloramphenicol, erythromycin and spiramycin. All antibiotics, except sulphadiazine, decreased chemiluminescence at 1000
μg/ml or lower concentrations. Enrofloxacin increased chemiluminescence. The inhibition by oxytetracycline and danofloxacin was due to absorption of the light emitted by luminol at 425 nm. Oxytetracycline, ceftiofur, spiramycin and erythromycin affected the myeloperoxidase–H
2O
2–halide system. Ceftiofur, penicillin and danofloxacin showed scavenging effects on H
2O
2 and OCl
-. Penicillin and ceftiofur might interfere with luminol. Chloramphenicol, penicillin and ceftiofur affected the production of superoxide radicals. In summary, the observed effects of antibiotics might be of importance during treatment of infectious diseases in normal and immunocompromised animals. However, before classifying a drug as immunosuppressive, attention has to be paid to possible interference with the chemiluminescence assay.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>9300263</pmid><doi>10.1016/S0014-2999(97)01107-2</doi><tpages>9</tpages></addata></record> |
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| ispartof | European journal of pharmacology, 1997-08, Vol.332 (3), p.289-297 |
| issn | 0014-2999 1879-0712 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Anti-Bacterial Agents - pharmacology Antibiotics Biological and medical sciences Cattle Cell Size - drug effects Cell Survival - drug effects Cell-Free System Drug toxicity and drugs side effects treatment Female Granulocytes - drug effects Granulocytes - metabolism Luminescent Measurements Medical sciences Neutrophils - drug effects Neutrophils - enzymology Peroxidase - blood Phagocytosis Phagocytosis - drug effects Pharmacology. Drug treatments Polymorphonuclear leukocytes Respiratory burst Respiratory Burst - drug effects Tetradecanoylphorbol Acetate - pharmacology Toxicity: blood |
| title | Effect of antibiotics on the phagocytotic and respiratory burst activity of bovine granulocytes |
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