MxA interacts with and is modified by the SUMOylation machinery

Mx proteins are evolutionarily conserved dynamin-like large GTPases involved in viral resistance triggered by types I and III interferons. The human MxA is a cytoplasmic protein that confers resistance to a large number of viruses. The MxA protein is also known to self-assembly into high molecular w...

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Veröffentlicht in:	Experimental cell research 2015-01, Vol.330 (1), p.151-163
Hauptverfasser:	Brantis-de-Carvalho, Carlos Eduardo, Maarifi, Ghizlane, Gonçalves Boldrin, Paulo Eduardo, Zanelli, Cleslei Fernando, Nisole, Sébastien, Chelbi-Alix, Mounira K., Valentini, Sandro Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Animals Binding Sites Cellular biology EIL loop HeLa Cells Humans Interferon Mice MX1 MxA Myxovirus Resistance Proteins - chemistry Myxovirus Resistance Proteins - metabolism NIH 3T3 Cells Protein Binding Proteins SUMO SUMO-1 Protein - chemistry SUMO-1 Protein - metabolism SUMOylation Ubc9 and antiviral activity Ubiquitin-Conjugating Enzymes - chemistry Ubiquitin-Conjugating Enzymes - metabolism Viruses Yeast Yeast two-hybrid
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