CD44 variant, but not standard CD44 isoforms, mediate disassembly of endothelial VE-cadherin junction on metastatic melanoma cells

•Melanoma contact induced VE-cadherin phosphorylation and endothelial gap formation.•Lu1205 melanoma cell expresses high levels of CD44v8-v10.•CD44v8-v10 but not CD44s facilitated Lu1205-induced endothelial gap formation.•CD44v8-v10 overexpression enhanced the ability of WM35 to induce junction loss...

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Veröffentlicht in:	FEBS letters 2014-12, Vol.588 (24), p.4573-4582
Hauptverfasser:	Zhang, Pu, Fu, Changliang, Bai, Huiyuan, Song, Erqun, Song, Yang
Format:	Artikel
Sprache:	eng
Schlagworte:	4′,6-diamidino-2-phenylindole Adherens junction Adherens Junctions - drug effects Adherens Junctions - metabolism benzyl-2-acetamido-2-deoxy-a-d-galactopyranoside benzyl-GalNAc Cadherins - metabolism CD44 standard isoform CD44 variant isoform CD44s CD44v Cell Adhesion Cell Line, Tumor Cell Movement DAPI deoxymannojirimycin DMJ EGFP endothelial cell Endothelial Cells - pathology enhanced green fluorescence protein Gene Knockdown Techniques human umbilical vein endothelial cell Humans HUVEC Hyaluronan Receptors - chemistry Hyaluronan Receptors - genetics Hyaluronan Receptors - metabolism Melanoma - pathology N-Acetylneuraminic Acid - metabolism Neoplasm Metastasis PBS phosphate buffered saline Phosphorylation Protein Isoforms - chemistry Protein Isoforms - deficiency Protein Isoforms - genetics Protein Isoforms - metabolism receptor tyrosine kinase RNA, Small Interfering - genetics RTK Short interfering RNA siRNA TCM tumor cell tumor conditioned medium Tumor metastasis vascular endothelial-cadherin VE-cadherin VE-cadherin phosphorylation
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