Zoledronic acid exerts antitumor effects in NB4 acute promyelocytic leukemia cells by inducing apoptosis and S phase arrest

Abstract The aim of this study was to investigate the antitumor effect of zoledronic acid (ZOL) in the NB4 human acute promyelocytic leukemia (APL) cell line and explore the potential mechanism of action of this compound. NB4 cells were exposed to various concentrations (0–200 μM) of ZOL. Cell viabi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biomedicine & pharmacotherapy 2014-10, Vol.68 (8), p.1031-1036
Hauptverfasser:	Liu, Shou-Sheng, Wang, Xiao-Pai, Li, Xiu-Bo, Liang, Jia-Yi, Liu, Ling-Ling, Lu, Ying, Zhong, Xue-Yun, Chen, Yun-Xian
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis Apoptosis - drug effects Apoptosis - physiology Arsenic trioxide Cell cycle Cell Cycle Checkpoints - drug effects Cell Cycle Checkpoints - physiology Diphosphonates - pharmacology Diphosphonates - therapeutic use Dose-Response Relationship, Drug Humans Imidazoles - pharmacology Imidazoles - therapeutic use Internal Medicine Leukemia, Promyelocytic, Acute - drug therapy Medical Education NB4 cells S Phase - drug effects S Phase - physiology Treatment Outcome Zoledronic acid
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!