Effects of the organophosphorous pesticide, dimethoate, on cardiac and acetylcholinesterase (AChE) activity in the shore crab Carcinus maenas
The potential use of biochemical and physiological responses as biomarkers of organophosphate exposure and/or effect were assessed in the shore crab ( Carcinus maenas). Male crabs were assigned to one of four dimethoate treatments (0, 0.5, 1.0 or 2.0 mg l −1). Cardiac activity was measured non-invas...
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| Veröffentlicht in: | Aquatic toxicology 1997-11, Vol.40 (1), p.23-36 |
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| creator | Lundebye, A.-K. Curtis, T.M. Braven, J. Depledge, M.H. |
| description | The potential use of biochemical and physiological responses as biomarkers of organophosphate exposure and/or effect were assessed in the shore crab (
Carcinus maenas). Male crabs were assigned to one of four dimethoate treatments (0, 0.5, 1.0 or 2.0 mg l
−1). Cardiac activity was measured non-invasively before and during dimethoate exposure using automated interpulse duration assessment. Heart rates decreased significantly in a concentration-dependent manner (
p < 0.05). Serial measurements of acetylcholinesterase activity in haemolymph samples taken from crabs before and after exposure indicated that 2 mg l
−1 dimethoate also significantly reduced acetylcholinesterase activity (
p < 0.05). The percentage inhibition in acetylcholinesterase activity was correlated with the percentage reduction in heart rate following dimethoate exposure (
r = 0.55,
p < 0.01). This suggests that organophosphates may directly effect neuronal control of the heart. The experiments indicate that non-destructive, serial measurements of cardiac activity and acetylcholinesterase activity are valuable biomarkers of organophosphate exposure and adverse effects. |
| doi_str_mv | 10.1016/S0166-445X(97)00045-3 |
| format | Article |
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Carcinus maenas). Male crabs were assigned to one of four dimethoate treatments (0, 0.5, 1.0 or 2.0 mg l
−1). Cardiac activity was measured non-invasively before and during dimethoate exposure using automated interpulse duration assessment. Heart rates decreased significantly in a concentration-dependent manner (
p < 0.05). Serial measurements of acetylcholinesterase activity in haemolymph samples taken from crabs before and after exposure indicated that 2 mg l
−1 dimethoate also significantly reduced acetylcholinesterase activity (
p < 0.05). The percentage inhibition in acetylcholinesterase activity was correlated with the percentage reduction in heart rate following dimethoate exposure (
r = 0.55,
p < 0.01). This suggests that organophosphates may directly effect neuronal control of the heart. The experiments indicate that non-destructive, serial measurements of cardiac activity and acetylcholinesterase activity are valuable biomarkers of organophosphate exposure and adverse effects.</description><identifier>ISSN: 0166-445X</identifier><identifier>EISSN: 1879-1514</identifier><identifier>DOI: 10.1016/S0166-445X(97)00045-3</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>Acetylcholinesterase ; Biomarkers ; Carcinus maenas ; Cardiac activity ; Crabs ; Marine</subject><ispartof>Aquatic toxicology, 1997-11, Vol.40 (1), p.23-36</ispartof><rights>1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-f78c9fa5788a1e9a59229105d1d7787fb2924337c6749161be055aa285d638df3</citedby><cites>FETCH-LOGICAL-c369t-f78c9fa5788a1e9a59229105d1d7787fb2924337c6749161be055aa285d638df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0166-445X(97)00045-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids></links><search><creatorcontrib>Lundebye, A.-K.</creatorcontrib><creatorcontrib>Curtis, T.M.</creatorcontrib><creatorcontrib>Braven, J.</creatorcontrib><creatorcontrib>Depledge, M.H.</creatorcontrib><title>Effects of the organophosphorous pesticide, dimethoate, on cardiac and acetylcholinesterase (AChE) activity in the shore crab Carcinus maenas</title><title>Aquatic toxicology</title><description>The potential use of biochemical and physiological responses as biomarkers of organophosphate exposure and/or effect were assessed in the shore crab (
Carcinus maenas). Male crabs were assigned to one of four dimethoate treatments (0, 0.5, 1.0 or 2.0 mg l
−1). Cardiac activity was measured non-invasively before and during dimethoate exposure using automated interpulse duration assessment. Heart rates decreased significantly in a concentration-dependent manner (
p < 0.05). Serial measurements of acetylcholinesterase activity in haemolymph samples taken from crabs before and after exposure indicated that 2 mg l
−1 dimethoate also significantly reduced acetylcholinesterase activity (
p < 0.05). The percentage inhibition in acetylcholinesterase activity was correlated with the percentage reduction in heart rate following dimethoate exposure (
r = 0.55,
p < 0.01). This suggests that organophosphates may directly effect neuronal control of the heart. The experiments indicate that non-destructive, serial measurements of cardiac activity and acetylcholinesterase activity are valuable biomarkers of organophosphate exposure and adverse effects.</description><subject>Acetylcholinesterase</subject><subject>Biomarkers</subject><subject>Carcinus maenas</subject><subject>Cardiac activity</subject><subject>Crabs</subject><subject>Marine</subject><issn>0166-445X</issn><issn>1879-1514</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNqFkVtrHCEUx4fSQrdJP0LBp5JAp9FRx_GphGV7gUAfmkDf5KweO5ZZ3aoJ7IfId67ZLX3Ngxfwf_Hw67p3jH5klI1XP9o29kLInxdaXVJKhez5i27FJqV7Jpl42a3-S153b0r53UR0EHrVPW68R1sLSZ7UGUnKvyCm_ZxKWzndF7LHUoMNDj8QF3ZY5wS13VMkFrILYAlER8BiPSx2TkuIzYAZCpKL6_W8uWxvNTyEeiAhHjtKS0ZiM2zJGrINsbXsACOU8-6Vh6Xg23_nWXf3eXO7_trffP_ybX1901s-6tp7NVntQappAoYapB4Gzah0zCk1Kb8d9CA4V3ZUQrORbZFKCTBM0o18cp6fde9Pufuc_ty3_5pdKBaXBSK2mQ0bWw_X6nmhEIoJzppQnoQ2p1IyerPPYQf5YBg1T5TMkZJ5QmC0MkdKhjffp5MP27gPAbMpNmC06EJuXIxL4ZmEvxKHm1Q</recordid><startdate>19971125</startdate><enddate>19971125</enddate><creator>Lundebye, A.-K.</creator><creator>Curtis, T.M.</creator><creator>Braven, J.</creator><creator>Depledge, M.H.</creator><general>Elsevier B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7TN</scope><scope>7U7</scope><scope>7UA</scope><scope>F1W</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope></search><sort><creationdate>19971125</creationdate><title>Effects of the organophosphorous pesticide, dimethoate, on cardiac and acetylcholinesterase (AChE) activity in the shore crab Carcinus maenas</title><author>Lundebye, A.-K. ; Curtis, T.M. ; Braven, J. ; Depledge, M.H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-f78c9fa5788a1e9a59229105d1d7787fb2924337c6749161be055aa285d638df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Acetylcholinesterase</topic><topic>Biomarkers</topic><topic>Carcinus maenas</topic><topic>Cardiac activity</topic><topic>Crabs</topic><topic>Marine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lundebye, A.-K.</creatorcontrib><creatorcontrib>Curtis, T.M.</creatorcontrib><creatorcontrib>Braven, J.</creatorcontrib><creatorcontrib>Depledge, M.H.</creatorcontrib><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>Aquatic toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lundebye, A.-K.</au><au>Curtis, T.M.</au><au>Braven, J.</au><au>Depledge, M.H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of the organophosphorous pesticide, dimethoate, on cardiac and acetylcholinesterase (AChE) activity in the shore crab Carcinus maenas</atitle><jtitle>Aquatic toxicology</jtitle><date>1997-11-25</date><risdate>1997</risdate><volume>40</volume><issue>1</issue><spage>23</spage><epage>36</epage><pages>23-36</pages><issn>0166-445X</issn><eissn>1879-1514</eissn><abstract>The potential use of biochemical and physiological responses as biomarkers of organophosphate exposure and/or effect were assessed in the shore crab (
Carcinus maenas). Male crabs were assigned to one of four dimethoate treatments (0, 0.5, 1.0 or 2.0 mg l
−1). Cardiac activity was measured non-invasively before and during dimethoate exposure using automated interpulse duration assessment. Heart rates decreased significantly in a concentration-dependent manner (
p < 0.05). Serial measurements of acetylcholinesterase activity in haemolymph samples taken from crabs before and after exposure indicated that 2 mg l
−1 dimethoate also significantly reduced acetylcholinesterase activity (
p < 0.05). The percentage inhibition in acetylcholinesterase activity was correlated with the percentage reduction in heart rate following dimethoate exposure (
r = 0.55,
p < 0.01). This suggests that organophosphates may directly effect neuronal control of the heart. The experiments indicate that non-destructive, serial measurements of cardiac activity and acetylcholinesterase activity are valuable biomarkers of organophosphate exposure and adverse effects.</abstract><pub>Elsevier B.V</pub><doi>10.1016/S0166-445X(97)00045-3</doi><tpages>14</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0166-445X |
| ispartof | Aquatic toxicology, 1997-11, Vol.40 (1), p.23-36 |
| issn | 0166-445X 1879-1514 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_16369397 |
| source | Elsevier ScienceDirect Journals Complete |
| subjects | Acetylcholinesterase Biomarkers Carcinus maenas Cardiac activity Crabs Marine |
| title | Effects of the organophosphorous pesticide, dimethoate, on cardiac and acetylcholinesterase (AChE) activity in the shore crab Carcinus maenas |
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