Biosynthesis and action of nitric oxide in mammalian cells

Nitric oxide (NO) can act as a vasorelaxant, a modulator of neurotransmission and a defence against pathogens. However, under certain conditions, NO can also have damaging effects to cells. Whether NO is useful or harmful depends on its chemical fate, and on the rate and location of its production....

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Veröffentlicht in:	Trends in Biochemical Sciences 1997-12, Vol.22 (12), p.477-481
Hauptverfasser:	Mayer, Bernd, Hemmens, Benjamin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biopterins - metabolism Calmodulin - metabolism Cardiovascular System - metabolism Central Nervous System - metabolism Cytochrome P-450 Enzyme System - metabolism Humans Immune System - metabolism Mammals - physiology Nitrates - metabolism Nitric Oxide - chemistry Nitric Oxide - physiology
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Beschreibung
Zusammenfassung:	Nitric oxide (NO) can act as a vasorelaxant, a modulator of neurotransmission and a defence against pathogens. However, under certain conditions, NO can also have damaging effects to cells. Whether NO is useful or harmful depends on its chemical fate, and on the rate and location of its production. Here, we discuss progress in NO chemistry and the enzymology of NO synthases, and we will also attempt to explai its actions in the cardiovascular, nervous and immune systems.
ISSN:	0968-0004 1362-4326
DOI:	10.1016/S0968-0004(97)01147-X