Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation

GLUTAMATE is important in several forms of synaptic plasticity such as long-term potentiation, and in neuronal cell degeneration 1,2 . Glutamate activates several types of receptors, including a metabotropic receptor that is sensitive to trans -1-amino-cyclopenthyl-l,3-dicarboxylate, coupled to G pr...

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Veröffentlicht in:	Nature (London) 1992-11, Vol.360 (6400), p.163-166
Hauptverfasser:	Herrero, Inmaculada, Miras-Portugal, M. Teresa, Sánchez-Prieto, José
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Aminopyridine - pharmacology Animals Arachidonic Acid - physiology Biological and medical sciences Calcium - physiology Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Cycloleucine - analogs & derivatives Cycloleucine - pharmacology Dose-Response Relationship, Drug Esters Exocytosis - drug effects Exocytosis - physiology Feedback Fundamental and applied biological sciences. Psychology Glutamates - biosynthesis Glutamic Acid Humanities and Social Sciences letter Male Medical research multidisciplinary Nervous system Neurotoxins - pharmacology Physiology Rats Rats, Wistar Receptors, Glutamate - metabolism Science Science (multidisciplinary) Synaptosomes - metabolism Vertebrates: nervous system and sense organs
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