Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation

GLUTAMATE is important in several forms of synaptic plasticity such as long-term potentiation, and in neuronal cell degeneration 1,2 . Glutamate activates several types of receptors, including a metabotropic receptor that is sensitive to trans -1-amino-cyclopenthyl-l,3-dicarboxylate, coupled to G pr...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nature (London) 1992-11, Vol.360 (6400), p.163-166
Hauptverfasser: Herrero, Inmaculada, Miras-Portugal, M. Teresa, Sánchez-Prieto, José
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 166
container_issue 6400
container_start_page 163
container_title Nature (London)
container_volume 360
creator Herrero, Inmaculada
Miras-Portugal, M. Teresa
Sánchez-Prieto, José
description GLUTAMATE is important in several forms of synaptic plasticity such as long-term potentiation, and in neuronal cell degeneration 1,2 . Glutamate activates several types of receptors, including a metabotropic receptor that is sensitive to trans -1-amino-cyclopenthyl-l,3-dicarboxylate, coupled to G protein(s) and linked to inositol phospholipid metabolism 3–6 . The activation of the metabotropic receptor in neurons generates inositol 1,4,5-trisphosphate, which causes the release of Ca 2+ from intracellular stores and diacylglycerol, which activates protein kinase C 7–9 . In nerve terminals, the activation of presynaptic protein kinase C with phorbol esters enhances glutamate release 10 . But the presynaptic receptor involved in this protein kinase C-mediated increase in the release of glutamate has not yet been identified. Here we demonstrate the presence of a presynaptic glutamate receptor of the metabotropic type that mediates an enhancement of glutamate exocytosis in cerebrocortical nerve terminals. Interestingly, this potentiation of glutamate release is observed only in the presence of arachidonic acid, which may reflect that this positive feedback control of glutamate exocytosis operates in concert with other pre- or post-synaptic events of the glutamatergic neurotransmission that generate arachidonic acid. This presynaptic glutamate receptor may have a physiological role in the maintenance of long-term potentiation where there is an increase in glutamate release mediated by postsynaptically generated arachidonic acid 11 .
doi_str_mv 10.1038/360163a0
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_16364873</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4946340</sourcerecordid><originalsourceid>FETCH-LOGICAL-c422t-af17cc393d4d8591d63213fa7b328969bd9242016c3f56f66d1db2ac8e2bff653</originalsourceid><addsrcrecordid>eNpt0F9L3jAUBvAwFPfqBvsCG0VE5kVd_jVNL0XUCYK70Btvyml6InVt0yXp2PvtjfTdK4hXCZwfT04eQr4wesqo0D-EokwJoB_IislS5VLpcoesKOU6p1qoj2Q_hCdKacFKuUf2mCgqyYsVefjlQhe7v5hZxLYB8ztzNnvs5wgDRMzwnzPrmEzImnU2YITGRe-mzmSTx7AeYYrp7tHgFJ3PQuyGuYfYufET2bXQB_y8OQ_I_eXF3fnP_Ob26vr87CY3kvOYg2WlMaISrWx1UbFWCc6EhbIRXFeqatqKS56-Z4QtlFWqZW3DwWjkjbWqEAfkeMmdvPszY4j10AWDfQ8jujnUqRgldSkSPHwDn9zsx7RbzamUQjD9kvZ9Qca7EDzaevLdAH5dM1q_dF3_7zrRr5u8uRmwfYVLuWl-tJlDMNBbD6PpwpZJUfFCVYmdLCykyfiI_nWtd578ttgR4uxxm7UFzx9Jnb8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>204433185</pqid></control><display><type>article</type><title>Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation</title><source>MEDLINE</source><source>Nature</source><source>Alma/SFX Local Collection</source><creator>Herrero, Inmaculada ; Miras-Portugal, M. Teresa ; Sánchez-Prieto, José</creator><creatorcontrib>Herrero, Inmaculada ; Miras-Portugal, M. Teresa ; Sánchez-Prieto, José</creatorcontrib><description>GLUTAMATE is important in several forms of synaptic plasticity such as long-term potentiation, and in neuronal cell degeneration 1,2 . Glutamate activates several types of receptors, including a metabotropic receptor that is sensitive to trans -1-amino-cyclopenthyl-l,3-dicarboxylate, coupled to G protein(s) and linked to inositol phospholipid metabolism 3–6 . The activation of the metabotropic receptor in neurons generates inositol 1,4,5-trisphosphate, which causes the release of Ca 2+ from intracellular stores and diacylglycerol, which activates protein kinase C 7–9 . In nerve terminals, the activation of presynaptic protein kinase C with phorbol esters enhances glutamate release 10 . But the presynaptic receptor involved in this protein kinase C-mediated increase in the release of glutamate has not yet been identified. Here we demonstrate the presence of a presynaptic glutamate receptor of the metabotropic type that mediates an enhancement of glutamate exocytosis in cerebrocortical nerve terminals. Interestingly, this potentiation of glutamate release is observed only in the presence of arachidonic acid, which may reflect that this positive feedback control of glutamate exocytosis operates in concert with other pre- or post-synaptic events of the glutamatergic neurotransmission that generate arachidonic acid. This presynaptic glutamate receptor may have a physiological role in the maintenance of long-term potentiation where there is an increase in glutamate release mediated by postsynaptically generated arachidonic acid 11 .</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/360163a0</identifier><identifier>PMID: 1359425</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>4-Aminopyridine - pharmacology ; Animals ; Arachidonic Acid - physiology ; Biological and medical sciences ; Calcium - physiology ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Cycloleucine - analogs &amp; derivatives ; Cycloleucine - pharmacology ; Dose-Response Relationship, Drug ; Esters ; Exocytosis - drug effects ; Exocytosis - physiology ; Feedback ; Fundamental and applied biological sciences. Psychology ; Glutamates - biosynthesis ; Glutamic Acid ; Humanities and Social Sciences ; letter ; Male ; Medical research ; multidisciplinary ; Nervous system ; Neurotoxins - pharmacology ; Physiology ; Rats ; Rats, Wistar ; Receptors, Glutamate - metabolism ; Science ; Science (multidisciplinary) ; Synaptosomes - metabolism ; Vertebrates: nervous system and sense organs</subject><ispartof>Nature (London), 1992-11, Vol.360 (6400), p.163-166</ispartof><rights>Springer Nature Limited 1992</rights><rights>1993 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. Nov 12, 1992</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-af17cc393d4d8591d63213fa7b328969bd9242016c3f56f66d1db2ac8e2bff653</citedby><cites>FETCH-LOGICAL-c422t-af17cc393d4d8591d63213fa7b328969bd9242016c3f56f66d1db2ac8e2bff653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2727,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=4392569$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1359425$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Herrero, Inmaculada</creatorcontrib><creatorcontrib>Miras-Portugal, M. Teresa</creatorcontrib><creatorcontrib>Sánchez-Prieto, José</creatorcontrib><title>Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>GLUTAMATE is important in several forms of synaptic plasticity such as long-term potentiation, and in neuronal cell degeneration 1,2 . Glutamate activates several types of receptors, including a metabotropic receptor that is sensitive to trans -1-amino-cyclopenthyl-l,3-dicarboxylate, coupled to G protein(s) and linked to inositol phospholipid metabolism 3–6 . The activation of the metabotropic receptor in neurons generates inositol 1,4,5-trisphosphate, which causes the release of Ca 2+ from intracellular stores and diacylglycerol, which activates protein kinase C 7–9 . In nerve terminals, the activation of presynaptic protein kinase C with phorbol esters enhances glutamate release 10 . But the presynaptic receptor involved in this protein kinase C-mediated increase in the release of glutamate has not yet been identified. Here we demonstrate the presence of a presynaptic glutamate receptor of the metabotropic type that mediates an enhancement of glutamate exocytosis in cerebrocortical nerve terminals. Interestingly, this potentiation of glutamate release is observed only in the presence of arachidonic acid, which may reflect that this positive feedback control of glutamate exocytosis operates in concert with other pre- or post-synaptic events of the glutamatergic neurotransmission that generate arachidonic acid. This presynaptic glutamate receptor may have a physiological role in the maintenance of long-term potentiation where there is an increase in glutamate release mediated by postsynaptically generated arachidonic acid 11 .</description><subject>4-Aminopyridine - pharmacology</subject><subject>Animals</subject><subject>Arachidonic Acid - physiology</subject><subject>Biological and medical sciences</subject><subject>Calcium - physiology</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Cycloleucine - analogs &amp; derivatives</subject><subject>Cycloleucine - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Esters</subject><subject>Exocytosis - drug effects</subject><subject>Exocytosis - physiology</subject><subject>Feedback</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glutamates - biosynthesis</subject><subject>Glutamic Acid</subject><subject>Humanities and Social Sciences</subject><subject>letter</subject><subject>Male</subject><subject>Medical research</subject><subject>multidisciplinary</subject><subject>Nervous system</subject><subject>Neurotoxins - pharmacology</subject><subject>Physiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, Glutamate - metabolism</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Synaptosomes - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpt0F9L3jAUBvAwFPfqBvsCG0VE5kVd_jVNL0XUCYK70Btvyml6InVt0yXp2PvtjfTdK4hXCZwfT04eQr4wesqo0D-EokwJoB_IislS5VLpcoesKOU6p1qoj2Q_hCdKacFKuUf2mCgqyYsVefjlQhe7v5hZxLYB8ztzNnvs5wgDRMzwnzPrmEzImnU2YITGRe-mzmSTx7AeYYrp7tHgFJ3PQuyGuYfYufET2bXQB_y8OQ_I_eXF3fnP_Ob26vr87CY3kvOYg2WlMaISrWx1UbFWCc6EhbIRXFeqatqKS56-Z4QtlFWqZW3DwWjkjbWqEAfkeMmdvPszY4j10AWDfQ8jujnUqRgldSkSPHwDn9zsx7RbzamUQjD9kvZ9Qca7EDzaevLdAH5dM1q_dF3_7zrRr5u8uRmwfYVLuWl-tJlDMNBbD6PpwpZJUfFCVYmdLCykyfiI_nWtd578ttgR4uxxm7UFzx9Jnb8</recordid><startdate>19921112</startdate><enddate>19921112</enddate><creator>Herrero, Inmaculada</creator><creator>Miras-Portugal, M. Teresa</creator><creator>Sánchez-Prieto, José</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T5</scope><scope>7TG</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>S0X</scope><scope>SOI</scope></search><sort><creationdate>19921112</creationdate><title>Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation</title><author>Herrero, Inmaculada ; Miras-Portugal, M. Teresa ; Sánchez-Prieto, José</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-af17cc393d4d8591d63213fa7b328969bd9242016c3f56f66d1db2ac8e2bff653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>4-Aminopyridine - pharmacology</topic><topic>Animals</topic><topic>Arachidonic Acid - physiology</topic><topic>Biological and medical sciences</topic><topic>Calcium - physiology</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Cycloleucine - analogs &amp; derivatives</topic><topic>Cycloleucine - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Esters</topic><topic>Exocytosis - drug effects</topic><topic>Exocytosis - physiology</topic><topic>Feedback</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glutamates - biosynthesis</topic><topic>Glutamic Acid</topic><topic>Humanities and Social Sciences</topic><topic>letter</topic><topic>Male</topic><topic>Medical research</topic><topic>multidisciplinary</topic><topic>Nervous system</topic><topic>Neurotoxins - pharmacology</topic><topic>Physiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, Glutamate - metabolism</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Synaptosomes - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Herrero, Inmaculada</creatorcontrib><creatorcontrib>Miras-Portugal, M. Teresa</creatorcontrib><creatorcontrib>Sánchez-Prieto, José</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Meteorological &amp; Geoastrophysical Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric &amp; Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Earth, Atmospheric &amp; Aquatic Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>University of Michigan</collection><collection>Genetics Abstracts</collection><collection>SIRS Editorial</collection><collection>Environment Abstracts</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Herrero, Inmaculada</au><au>Miras-Portugal, M. Teresa</au><au>Sánchez-Prieto, José</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1992-11-12</date><risdate>1992</risdate><volume>360</volume><issue>6400</issue><spage>163</spage><epage>166</epage><pages>163-166</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>GLUTAMATE is important in several forms of synaptic plasticity such as long-term potentiation, and in neuronal cell degeneration 1,2 . Glutamate activates several types of receptors, including a metabotropic receptor that is sensitive to trans -1-amino-cyclopenthyl-l,3-dicarboxylate, coupled to G protein(s) and linked to inositol phospholipid metabolism 3–6 . The activation of the metabotropic receptor in neurons generates inositol 1,4,5-trisphosphate, which causes the release of Ca 2+ from intracellular stores and diacylglycerol, which activates protein kinase C 7–9 . In nerve terminals, the activation of presynaptic protein kinase C with phorbol esters enhances glutamate release 10 . But the presynaptic receptor involved in this protein kinase C-mediated increase in the release of glutamate has not yet been identified. Here we demonstrate the presence of a presynaptic glutamate receptor of the metabotropic type that mediates an enhancement of glutamate exocytosis in cerebrocortical nerve terminals. Interestingly, this potentiation of glutamate release is observed only in the presence of arachidonic acid, which may reflect that this positive feedback control of glutamate exocytosis operates in concert with other pre- or post-synaptic events of the glutamatergic neurotransmission that generate arachidonic acid. This presynaptic glutamate receptor may have a physiological role in the maintenance of long-term potentiation where there is an increase in glutamate release mediated by postsynaptically generated arachidonic acid 11 .</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>1359425</pmid><doi>10.1038/360163a0</doi><tpages>4</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0028-0836
ispartof Nature (London), 1992-11, Vol.360 (6400), p.163-166
issn 0028-0836
1476-4687
language eng
recordid cdi_proquest_miscellaneous_16364873
source MEDLINE; Nature; Alma/SFX Local Collection
subjects 4-Aminopyridine - pharmacology
Animals
Arachidonic Acid - physiology
Biological and medical sciences
Calcium - physiology
Central nervous system
Central neurotransmission. Neuromudulation. Pathways and receptors
Cycloleucine - analogs & derivatives
Cycloleucine - pharmacology
Dose-Response Relationship, Drug
Esters
Exocytosis - drug effects
Exocytosis - physiology
Feedback
Fundamental and applied biological sciences. Psychology
Glutamates - biosynthesis
Glutamic Acid
Humanities and Social Sciences
letter
Male
Medical research
multidisciplinary
Nervous system
Neurotoxins - pharmacology
Physiology
Rats
Rats, Wistar
Receptors, Glutamate - metabolism
Science
Science (multidisciplinary)
Synaptosomes - metabolism
Vertebrates: nervous system and sense organs
title Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T17%3A22%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Positive%20feedback%20of%20glutamate%20exocytosis%20by%20metabotropic%20presynaptic%20receptor%20stimulation&rft.jtitle=Nature%20(London)&rft.au=Herrero,%20Inmaculada&rft.date=1992-11-12&rft.volume=360&rft.issue=6400&rft.spage=163&rft.epage=166&rft.pages=163-166&rft.issn=0028-0836&rft.eissn=1476-4687&rft.coden=NATUAS&rft_id=info:doi/10.1038/360163a0&rft_dat=%3Cproquest_cross%3E4946340%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=204433185&rft_id=info:pmid/1359425&rfr_iscdi=true