Effect of Sobatum on radiation-induced toxicity in mice
Sobatum, the active fraction of the plant Solanum trilobatum was obtained from the petroleum ether/ethyl acetate (75:25) extractable portion. Sobatum was proven to be an anticancer agent by in vitro and in vivo methods. The aim of this study is to evaluate the effect of Sobatum on radiation-induced...
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| Veröffentlicht in: | Cancer letters 1998-01, Vol.123 (2), p.141-145 |
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| creator | Mohanan, P.V Devi, K.S |
| description | Sobatum, the active fraction of the plant
Solanum trilobatum was obtained from the petroleum ether/ethyl acetate (75:25) extractable portion. Sobatum was proven to be an anticancer agent by in vitro and in vivo methods. The aim of this study is to evaluate the effect of Sobatum on radiation-induced toxicity in mice. In this assay there are three groups. Group I, the control group, received radiation alone, while groups II and III received Sobatum (100 and 200 mg/kg body weight, respectively) with radiation. Sobatum was administered 24 h before radiation and was continued for 4 alternate days. Body weight, food intake and blood parameters were determined before radiation and every 3 days after radiation for 17 days. The results indicated that there was significantly less body weight gain and food intake in the radiation alone-treated group compared to the Sobatum-treated group. The average leukocyte count and haemoglobin level of the Sobatum-treated group was considerably improved at the end of the experimental period. Hence, it can be concluded that Sobatum reduced the side-effects of radiation-induced toxicity and suggested that it could be used along with radiation therapy. |
| doi_str_mv | 10.1016/S0304-3835(97)00408-4 |
| format | Article |
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Solanum trilobatum was obtained from the petroleum ether/ethyl acetate (75:25) extractable portion. Sobatum was proven to be an anticancer agent by in vitro and in vivo methods. The aim of this study is to evaluate the effect of Sobatum on radiation-induced toxicity in mice. In this assay there are three groups. Group I, the control group, received radiation alone, while groups II and III received Sobatum (100 and 200 mg/kg body weight, respectively) with radiation. Sobatum was administered 24 h before radiation and was continued for 4 alternate days. Body weight, food intake and blood parameters were determined before radiation and every 3 days after radiation for 17 days. The results indicated that there was significantly less body weight gain and food intake in the radiation alone-treated group compared to the Sobatum-treated group. The average leukocyte count and haemoglobin level of the Sobatum-treated group was considerably improved at the end of the experimental period. Hence, it can be concluded that Sobatum reduced the side-effects of radiation-induced toxicity and suggested that it could be used along with radiation therapy.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/S0304-3835(97)00408-4</identifier><identifier>PMID: 9489480</identifier><identifier>CODEN: CALEDQ</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Anticarcinogenic Agents - pharmacology ; Antineoplastic agents ; Biological and medical sciences ; Body Weight - drug effects ; Body Weight - radiation effects ; Combined treatments (chemotherapy of immunotherapy associated with an other treatment) ; Cytotoxicity ; DLA ; Eating - drug effects ; Eating - radiation effects ; Evaluation Studies as Topic ; Haemoglobin ; Hemoglobins - drug effects ; Hemoglobins - radiation effects ; Leukocyte Count - drug effects ; Leukocyte Count - radiation effects ; Leukocytes ; Male ; Medical sciences ; Mice ; Pharmacology. Drug treatments ; Plant Extracts - pharmacology ; Radiation ; Radiation Injuries, Experimental - mortality ; Radiation Injuries, Experimental - prevention & control ; Sobatum ; Survival Rate</subject><ispartof>Cancer letters, 1998-01, Vol.123 (2), p.141-145</ispartof><rights>1998 Elsevier Science Ireland Ltd</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c515t-683230f1c99e4976a60539e13f8f6c58b8ceab885c1adfa9fa8d7034524deb583</citedby><cites>FETCH-LOGICAL-c515t-683230f1c99e4976a60539e13f8f6c58b8ceab885c1adfa9fa8d7034524deb583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304383597004084$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2273976$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9489480$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mohanan, P.V</creatorcontrib><creatorcontrib>Devi, K.S</creatorcontrib><title>Effect of Sobatum on radiation-induced toxicity in mice</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Sobatum, the active fraction of the plant
Solanum trilobatum was obtained from the petroleum ether/ethyl acetate (75:25) extractable portion. Sobatum was proven to be an anticancer agent by in vitro and in vivo methods. The aim of this study is to evaluate the effect of Sobatum on radiation-induced toxicity in mice. In this assay there are three groups. Group I, the control group, received radiation alone, while groups II and III received Sobatum (100 and 200 mg/kg body weight, respectively) with radiation. Sobatum was administered 24 h before radiation and was continued for 4 alternate days. Body weight, food intake and blood parameters were determined before radiation and every 3 days after radiation for 17 days. The results indicated that there was significantly less body weight gain and food intake in the radiation alone-treated group compared to the Sobatum-treated group. The average leukocyte count and haemoglobin level of the Sobatum-treated group was considerably improved at the end of the experimental period. Hence, it can be concluded that Sobatum reduced the side-effects of radiation-induced toxicity and suggested that it could be used along with radiation therapy.</description><subject>Animals</subject><subject>Anticarcinogenic Agents - pharmacology</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Body Weight - drug effects</subject><subject>Body Weight - radiation effects</subject><subject>Combined treatments (chemotherapy of immunotherapy associated with an other treatment)</subject><subject>Cytotoxicity</subject><subject>DLA</subject><subject>Eating - drug effects</subject><subject>Eating - radiation effects</subject><subject>Evaluation Studies as Topic</subject><subject>Haemoglobin</subject><subject>Hemoglobins - drug effects</subject><subject>Hemoglobins - radiation effects</subject><subject>Leukocyte Count - drug effects</subject><subject>Leukocyte Count - radiation effects</subject><subject>Leukocytes</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Extracts - pharmacology</subject><subject>Radiation</subject><subject>Radiation Injuries, Experimental - mortality</subject><subject>Radiation Injuries, Experimental - prevention & control</subject><subject>Sobatum</subject><subject>Survival Rate</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLAzEQgIMotVZ_QmEPInpYnWySTXISKfUBBQ_Vc8hmE4h0NzXZFfvv3T7oVRiYw3zz-hCaYrjHgMuHJRCgORGE3Up-B0BB5PQEjbHgRc6lgFM0PiLn6CKlLwBglLMRGkkqhoAx4nPnrOmy4LJlqHTXN1los6hrrzsf2ty3dW9snXXh1xvfbTLfZo039hKdOb1K9uqQJ-jzef4xe80X7y9vs6dFbhhmXV4KUhBw2EhpqeSlLoERaTFxwpWGiUoYqyshmMG6dlo6LWoOhLKC1rZigkzQzX7uOobv3qZONT4Zu1rp1oY-KVySEgpOB5DtQRNDStE6tY6-0XGjMKitMLUTprY2lORqJ0xt-6aHBX3V2PrYdTA01K8PdZ2MXrmoW-PTESsKToa_Buxxj9lBxo-3USXjbTuo83Hwq-rg_znkD08ohhM</recordid><startdate>19980101</startdate><enddate>19980101</enddate><creator>Mohanan, P.V</creator><creator>Devi, K.S</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19980101</creationdate><title>Effect of Sobatum on radiation-induced toxicity in mice</title><author>Mohanan, P.V ; Devi, K.S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c515t-683230f1c99e4976a60539e13f8f6c58b8ceab885c1adfa9fa8d7034524deb583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Anticarcinogenic Agents - pharmacology</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Body Weight - drug effects</topic><topic>Body Weight - radiation effects</topic><topic>Combined treatments (chemotherapy of immunotherapy associated with an other treatment)</topic><topic>Cytotoxicity</topic><topic>DLA</topic><topic>Eating - drug effects</topic><topic>Eating - radiation effects</topic><topic>Evaluation Studies as Topic</topic><topic>Haemoglobin</topic><topic>Hemoglobins - drug effects</topic><topic>Hemoglobins - radiation effects</topic><topic>Leukocyte Count - drug effects</topic><topic>Leukocyte Count - radiation effects</topic><topic>Leukocytes</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Extracts - pharmacology</topic><topic>Radiation</topic><topic>Radiation Injuries, Experimental - mortality</topic><topic>Radiation Injuries, Experimental - prevention & control</topic><topic>Sobatum</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mohanan, P.V</creatorcontrib><creatorcontrib>Devi, K.S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mohanan, P.V</au><au>Devi, K.S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Sobatum on radiation-induced toxicity in mice</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>1998-01-01</date><risdate>1998</risdate><volume>123</volume><issue>2</issue><spage>141</spage><epage>145</epage><pages>141-145</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><coden>CALEDQ</coden><abstract>Sobatum, the active fraction of the plant
Solanum trilobatum was obtained from the petroleum ether/ethyl acetate (75:25) extractable portion. Sobatum was proven to be an anticancer agent by in vitro and in vivo methods. The aim of this study is to evaluate the effect of Sobatum on radiation-induced toxicity in mice. In this assay there are three groups. Group I, the control group, received radiation alone, while groups II and III received Sobatum (100 and 200 mg/kg body weight, respectively) with radiation. Sobatum was administered 24 h before radiation and was continued for 4 alternate days. Body weight, food intake and blood parameters were determined before radiation and every 3 days after radiation for 17 days. The results indicated that there was significantly less body weight gain and food intake in the radiation alone-treated group compared to the Sobatum-treated group. The average leukocyte count and haemoglobin level of the Sobatum-treated group was considerably improved at the end of the experimental period. Hence, it can be concluded that Sobatum reduced the side-effects of radiation-induced toxicity and suggested that it could be used along with radiation therapy.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>9489480</pmid><doi>10.1016/S0304-3835(97)00408-4</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 1998-01, Vol.123 (2), p.141-145 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Anticarcinogenic Agents - pharmacology Antineoplastic agents Biological and medical sciences Body Weight - drug effects Body Weight - radiation effects Combined treatments (chemotherapy of immunotherapy associated with an other treatment) Cytotoxicity DLA Eating - drug effects Eating - radiation effects Evaluation Studies as Topic Haemoglobin Hemoglobins - drug effects Hemoglobins - radiation effects Leukocyte Count - drug effects Leukocyte Count - radiation effects Leukocytes Male Medical sciences Mice Pharmacology. Drug treatments Plant Extracts - pharmacology Radiation Radiation Injuries, Experimental - mortality Radiation Injuries, Experimental - prevention & control Sobatum Survival Rate |
| title | Effect of Sobatum on radiation-induced toxicity in mice |
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