Evolution of the cytochrome P450 superfamily: sequence alignments and pharmacogenetics

The evolution of the cytochrome P450 (CYP) superfamily is described, with particular reference to major events in the development of biological forms during geological time. It is noted that the currently accepted timescale for the elaboration of the P450 phylogenetic tree exhibits close parallels w...

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Veröffentlicht in:	Mutation research 1998-06, Vol.410 (3), p.245-270
Hauptverfasser:	Lewis, D.F.V., Watson, E., Lake, B.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biological and medical sciences Classical genetics, quantitative genetics, hybrids Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 Evolution Evolution, Molecular Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Human Humans Models, Molecular Molecular Sequence Data Multigene Family Pharmacogenetics Phylogeny Sequence Alignment Space life sciences Species Specificity Xenobiotics - metabolism
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