Molecular cloning and characterization of the major endothelin receptor subtype in porcine cerebellum
Endothelin receptors (ETRs) display subtype heterogeneity and are widely distributed throughout the tissues of the periphery and central nervous system. In order to gain further insight into the potential molecular differences of ETRs, we initiated molecular cloning of ETR genes by screening for the...
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| Veröffentlicht in: | Molecular pharmacology 1992-01, Vol.41 (2), p.465-473 |
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| container_end_page | 473 |
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| container_issue | 2 |
| container_start_page | 465 |
| container_title | Molecular pharmacology |
| container_volume | 41 |
| creator | Elshourbagy, NA Lee, JA Korman, DR Nuthalaganti, P Sylvester, DR Dilella, A G Sutiphong, JA Kumar, C S |
| description | Endothelin receptors (ETRs) display subtype heterogeneity and are widely distributed throughout the tissues of the periphery and central nervous system. In order to gain further insight into the potential molecular differences of ETRs, we initiated molecular cloning of ETR genes by screening for the appearance of super(125)I-ET-1 binding activity in COS cells transfected with pools of a porcine cerebellum cDNA expression library. The data demonstrate that the pPCETR 1.1 encodes the major ETR subtype in the porcine cerebellum. |
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In order to gain further insight into the potential molecular differences of ETRs, we initiated molecular cloning of ETR genes by screening for the appearance of super(125)I-ET-1 binding activity in COS cells transfected with pools of a porcine cerebellum cDNA expression library. The data demonstrate that the pPCETR 1.1 encodes the major ETR subtype in the porcine cerebellum.</description><identifier>ISSN: 0026-895X</identifier><language>eng</language><subject>amino acid sequence ; cDNA ; cerebellum ; characterization ; endothelin ; genes ; isoforms ; membrane proteins ; nucleotide sequence ; pigs ; prediction ; receptors</subject><ispartof>Molecular pharmacology, 1992-01, Vol.41 (2), p.465-473</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids></links><search><creatorcontrib>Elshourbagy, NA</creatorcontrib><creatorcontrib>Lee, JA</creatorcontrib><creatorcontrib>Korman, DR</creatorcontrib><creatorcontrib>Nuthalaganti, P</creatorcontrib><creatorcontrib>Sylvester, DR</creatorcontrib><creatorcontrib>Dilella, A G</creatorcontrib><creatorcontrib>Sutiphong, JA</creatorcontrib><creatorcontrib>Kumar, C S</creatorcontrib><title>Molecular cloning and characterization of the major endothelin receptor subtype in porcine cerebellum</title><title>Molecular pharmacology</title><description>Endothelin receptors (ETRs) display subtype heterogeneity and are widely distributed throughout the tissues of the periphery and central nervous system. 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The data demonstrate that the pPCETR 1.1 encodes the major ETR subtype in the porcine cerebellum.</description><subject>amino acid sequence</subject><subject>cDNA</subject><subject>cerebellum</subject><subject>characterization</subject><subject>endothelin</subject><subject>genes</subject><subject>isoforms</subject><subject>membrane proteins</subject><subject>nucleotide sequence</subject><subject>pigs</subject><subject>prediction</subject><subject>receptors</subject><issn>0026-895X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><recordid>eNqNirsOgjAUQDtoIj7-4U5uJEUsgdloXNwc3EgpFykpvdjHoF8vgx_gdHJOzoIlnB-KtKzEY8XW3g-cZ0dR8oThjQyqaKQDZchq-wRpW1C9dFIFdPojgyYL1EHoEUY5kAO0Lc1mtAWHCqcwNx-b8J4Q5jaRU9oiKHTYoDFx3LJlJ43H3Y8btr-c76drOjl6RfShHrVX8yotUvR1VuSi4iLL_x6_hnxKpA</recordid><startdate>19920101</startdate><enddate>19920101</enddate><creator>Elshourbagy, NA</creator><creator>Lee, JA</creator><creator>Korman, DR</creator><creator>Nuthalaganti, P</creator><creator>Sylvester, DR</creator><creator>Dilella, A G</creator><creator>Sutiphong, JA</creator><creator>Kumar, C S</creator><scope>7QL</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7Z</scope><scope>M81</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>19920101</creationdate><title>Molecular cloning and characterization of the major endothelin receptor subtype in porcine cerebellum</title><author>Elshourbagy, NA ; Lee, JA ; Korman, DR ; Nuthalaganti, P ; Sylvester, DR ; Dilella, A G ; Sutiphong, JA ; Kumar, C S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_163590513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>amino acid sequence</topic><topic>cDNA</topic><topic>cerebellum</topic><topic>characterization</topic><topic>endothelin</topic><topic>genes</topic><topic>isoforms</topic><topic>membrane proteins</topic><topic>nucleotide sequence</topic><topic>pigs</topic><topic>prediction</topic><topic>receptors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elshourbagy, NA</creatorcontrib><creatorcontrib>Lee, JA</creatorcontrib><creatorcontrib>Korman, DR</creatorcontrib><creatorcontrib>Nuthalaganti, P</creatorcontrib><creatorcontrib>Sylvester, DR</creatorcontrib><creatorcontrib>Dilella, A G</creatorcontrib><creatorcontrib>Sutiphong, JA</creatorcontrib><creatorcontrib>Kumar, C S</creatorcontrib><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biochemistry Abstracts 3</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Molecular pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elshourbagy, NA</au><au>Lee, JA</au><au>Korman, DR</au><au>Nuthalaganti, P</au><au>Sylvester, DR</au><au>Dilella, A G</au><au>Sutiphong, JA</au><au>Kumar, C S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular cloning and characterization of the major endothelin receptor subtype in porcine cerebellum</atitle><jtitle>Molecular pharmacology</jtitle><date>1992-01-01</date><risdate>1992</risdate><volume>41</volume><issue>2</issue><spage>465</spage><epage>473</epage><pages>465-473</pages><issn>0026-895X</issn><abstract>Endothelin receptors (ETRs) display subtype heterogeneity and are widely distributed throughout the tissues of the periphery and central nervous system. In order to gain further insight into the potential molecular differences of ETRs, we initiated molecular cloning of ETR genes by screening for the appearance of super(125)I-ET-1 binding activity in COS cells transfected with pools of a porcine cerebellum cDNA expression library. The data demonstrate that the pPCETR 1.1 encodes the major ETR subtype in the porcine cerebellum.</abstract></addata></record> |
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| identifier | ISSN: 0026-895X |
| ispartof | Molecular pharmacology, 1992-01, Vol.41 (2), p.465-473 |
| issn | 0026-895X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_16359051 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | amino acid sequence cDNA cerebellum characterization endothelin genes isoforms membrane proteins nucleotide sequence pigs prediction receptors |
| title | Molecular cloning and characterization of the major endothelin receptor subtype in porcine cerebellum |
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