Effect of proteasome inhibitors on monocytic IκB‐α and ‐β depletion, NF‐κB activation, and cytokine production

We investigated the effect of proteasome inhibitors on the lipopolysaccharide (LPS)‐induced expression of several monocytic cytokines, which may be dependent on the transcription factor, nuclear factor‐κB (NF‐κB). Exposure of human monocytic THP‐1 cells to ALLN and Mu873 prevented the LPS‐induced de...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of leukocyte biology 1998-03, Vol.63 (3), p.395-404
Hauptverfasser:	Haas, Monika, Page, Sharon, Page, Michael, Neumann, Franz‐Josef, Marx, Nikolaus, Adam, Michaela, Ziegler‐Heitbrock, H. W. Löms, Neumeier, Dieter, Brand, Korbinian
Format:	Artikel
Sprache:	eng
Schlagworte:	interleukin‐1β interleukin‐8 lipopolysaccharide transcription factors tumor necrosis factor
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!