Cationic proteins of neutrophil azurophilic granules: protein-protein interaction and blockade of NADPH oxidase activation

We have previously reported inhibition of cell‐free activation of the neutrophil superoxidegenerating NADPH oxidase by a soluble cationic protein of neutrophil granules and by low concentrations of human defensin. Subcellular fractionation carried out in the current study indicated that the inhibito...

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Veröffentlicht in:	Journal of leukocyte biology 1998-03, Vol.63 (3), p.305-311
Hauptverfasser:	Tal, Tal, Michaela, Sharabani, Irit, Aviram
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Fractionation Cell-Free System Centrifugation, Density Gradient Chromatography, Affinity Chromatography, Gel Cytoplasmic Granules - drug effects Cytoplasmic Granules - physiology Cytoplasmic Granules - ultrastructure Cytosol - physiology Enzyme Activation Humans lysozyme Muramidase - blood Myeloblastin N-Formylmethionine Leucyl-Phenylalanine - pharmacology NADPH Oxidases - antagonists & inhibitors NADPH Oxidases - blood Neutrophils - drug effects Neutrophils - physiology Neutrophils - ultrastructure Phenylmethylsulfonyl Fluoride - pharmacology proteinase Respiratory Burst Serine Endopeptidases - blood subcellular fractionation Superoxides - blood Tetradecanoylphorbol Acetate - pharmacology
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