Increased exposure to dietary amines and nitrate in a population at high risk of oesophageal and gastric cancer in Kashmir (India)
Analytical data on aliphatic amines and nitrate from the most commonly used fresh and sun-dried vegetables, red chillies and a widely consumed beverage, salted tea, are presented from a high risk area for oesophageal and gastric cancer in Kashmir. Exposure estimates for the adult population show tha...
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| Veröffentlicht in: | Carcinogenesis (New York) 1992-08, Vol.13 (8), p.1331-1335 |
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| container_title | Carcinogenesis (New York) |
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| creator | Siddiqi, Maqsood Kumar, Rajiv Fazili, Zia Spiegelhalder, Bertold Preussmann, Rudolf |
| description | Analytical data on aliphatic amines and nitrate from the most commonly used fresh and sun-dried vegetables, red chillies and a widely consumed beverage, salted tea, are presented from a high risk area for oesophageal and gastric cancer in Kashmir. Exposure estimates for the adult population show that high consumption of boiled Brassica vegetables leads to a high nitrate intake of 237 mg/day. The frequent consumption of hot salted tea is shown to result in exceptionally high exposure to methylamine (1200 μg/day), ethylamine (14 320 μg/day), dimethylamine (150 μg/day) and diethyl-amine (400 μg/day). The indiscriminate use of red chillies in the area leads to exposure to dimethylamine (280 μg/day), pyrrolidine (517 μg/day) and methylbenzylamine (40 μg/day). This is to our knowledge the first report where a chronic exposure to methylbenzylamine has been shown in a population at high risk of oesophageal cancer. |
| doi_str_mv | 10.1093/carcin/13.8.1331 |
| format | Article |
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Exposure estimates for the adult population show that high consumption of boiled Brassica vegetables leads to a high nitrate intake of 237 mg/day. The frequent consumption of hot salted tea is shown to result in exceptionally high exposure to methylamine (1200 μg/day), ethylamine (14 320 μg/day), dimethylamine (150 μg/day) and diethyl-amine (400 μg/day). The indiscriminate use of red chillies in the area leads to exposure to dimethylamine (280 μg/day), pyrrolidine (517 μg/day) and methylbenzylamine (40 μg/day). 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Anus ; Tea - chemistry ; Tumors ; Vegetables - chemistry</subject><ispartof>Carcinogenesis (New York), 1992-08, Vol.13 (8), p.1331-1335</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c307t-3e15d6455eab4d920ce586c5ba7eaa8f0d29366cd0bad266b23975a56fb44e243</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27925,27926</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5453618$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1499084$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Siddiqi, Maqsood</creatorcontrib><creatorcontrib>Kumar, Rajiv</creatorcontrib><creatorcontrib>Fazili, Zia</creatorcontrib><creatorcontrib>Spiegelhalder, Bertold</creatorcontrib><creatorcontrib>Preussmann, Rudolf</creatorcontrib><title>Increased exposure to dietary amines and nitrate in a population at high risk of oesophageal and gastric cancer in Kashmir (India)</title><title>Carcinogenesis (New York)</title><addtitle>Carcinogenesis</addtitle><description>Analytical data on aliphatic amines and nitrate from the most commonly used fresh and sun-dried vegetables, red chillies and a widely consumed beverage, salted tea, are presented from a high risk area for oesophageal and gastric cancer in Kashmir. Exposure estimates for the adult population show that high consumption of boiled Brassica vegetables leads to a high nitrate intake of 237 mg/day. The frequent consumption of hot salted tea is shown to result in exceptionally high exposure to methylamine (1200 μg/day), ethylamine (14 320 μg/day), dimethylamine (150 μg/day) and diethyl-amine (400 μg/day). The indiscriminate use of red chillies in the area leads to exposure to dimethylamine (280 μg/day), pyrrolidine (517 μg/day) and methylbenzylamine (40 μg/day). This is to our knowledge the first report where a chronic exposure to methylbenzylamine has been shown in a population at high risk of oesophageal cancer.</description><subject>Adult</subject><subject>Amines - adverse effects</subject><subject>Amines - analysis</subject><subject>Biological and medical sciences</subject><subject>Condiments - analysis</subject><subject>Diet</subject><subject>Esophageal Neoplasms - epidemiology</subject><subject>Food Analysis</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>India - epidemiology</subject><subject>Medical sciences</subject><subject>Nitrates - adverse effects</subject><subject>Nitrates - analysis</subject><subject>Stomach Neoplasms - epidemiology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>India - epidemiology</topic><topic>Medical sciences</topic><topic>Nitrates - adverse effects</topic><topic>Nitrates - analysis</topic><topic>Stomach Neoplasms - epidemiology</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tea - chemistry</topic><topic>Tumors</topic><topic>Vegetables - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Siddiqi, Maqsood</creatorcontrib><creatorcontrib>Kumar, Rajiv</creatorcontrib><creatorcontrib>Fazili, Zia</creatorcontrib><creatorcontrib>Spiegelhalder, Bertold</creatorcontrib><creatorcontrib>Preussmann, Rudolf</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Carcinogenesis (New York)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Siddiqi, Maqsood</au><au>Kumar, Rajiv</au><au>Fazili, Zia</au><au>Spiegelhalder, Bertold</au><au>Preussmann, Rudolf</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased exposure to dietary amines and nitrate in a population at high risk of oesophageal and gastric cancer in Kashmir (India)</atitle><jtitle>Carcinogenesis (New York)</jtitle><addtitle>Carcinogenesis</addtitle><date>1992-08</date><risdate>1992</risdate><volume>13</volume><issue>8</issue><spage>1331</spage><epage>1335</epage><pages>1331-1335</pages><issn>0143-3334</issn><eissn>1460-2180</eissn><coden>CRNGDP</coden><abstract>Analytical data on aliphatic amines and nitrate from the most commonly used fresh and sun-dried vegetables, red chillies and a widely consumed beverage, salted tea, are presented from a high risk area for oesophageal and gastric cancer in Kashmir. Exposure estimates for the adult population show that high consumption of boiled Brassica vegetables leads to a high nitrate intake of 237 mg/day. The frequent consumption of hot salted tea is shown to result in exceptionally high exposure to methylamine (1200 μg/day), ethylamine (14 320 μg/day), dimethylamine (150 μg/day) and diethyl-amine (400 μg/day). The indiscriminate use of red chillies in the area leads to exposure to dimethylamine (280 μg/day), pyrrolidine (517 μg/day) and methylbenzylamine (40 μg/day). This is to our knowledge the first report where a chronic exposure to methylbenzylamine has been shown in a population at high risk of oesophageal cancer.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>1499084</pmid><doi>10.1093/carcin/13.8.1331</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0143-3334 |
| ispartof | Carcinogenesis (New York), 1992-08, Vol.13 (8), p.1331-1335 |
| issn | 0143-3334 1460-2180 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Adult Amines - adverse effects Amines - analysis Biological and medical sciences Condiments - analysis Diet Esophageal Neoplasms - epidemiology Food Analysis Gastroenterology. Liver. Pancreas. Abdomen Humans India - epidemiology Medical sciences Nitrates - adverse effects Nitrates - analysis Stomach Neoplasms - epidemiology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tea - chemistry Tumors Vegetables - chemistry |
| title | Increased exposure to dietary amines and nitrate in a population at high risk of oesophageal and gastric cancer in Kashmir (India) |
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