Non‐immunoglobulin serum proteins prevent the binding of IgG from normal rats and from rats with Th2‐mediated autoimmune glomerulonephritis to various autoantigens including glomerular antigens

It is now well established in normal humans and mice that purification of IgG from serum unmasks their autoantibody activity. Mercuric chloride (HgCl2 ) induces in Brown‐Norway (BN) rats a Th2‐dependent polyclonal B cell activation, a huge increase in serum IgE and IgG1 concentrations, the productio...

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Veröffentlicht in:	European journal of immunology 1998-01, Vol.28 (1), p.183-192
Hauptverfasser:	Druet, Elvira, Praddaude, Françoise, Druet, Philippe, Dietrich, Gilles
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen binding Antigen-Antibody Reactions - drug effects Autoantibodies Autoantibodies - blood Autoantibodies - immunology Autoantibodies - isolation & purification Autoantibodies - metabolism Autoantigens - immunology Autoantigens - metabolism Autoimmune Diseases - blood Autoimmune Diseases - chemically induced Autoimmune Diseases - immunology Autoimmunity Blood Proteins - pharmacology Culture Media, Serum-Free Female Glomerulonephritis - blood Glomerulonephritis - chemically induced Glomerulonephritis - immunology Immunoglobulin E - immunology Immunoglobulin G - blood Immunoglobulin G - immunology Immunoglobulin G - isolation & purification Immunoglobulin G - metabolism Immunoglobulin M - immunology Lymphocyte Activation Lymphocyte Cooperation Male Mercuric Chloride - toxicity Mice Rats Rats, Inbred BN Rats, Sprague-Dawley Serum Albumin, Bovine - immunology Th2 Cells - immunology
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