A point mutation within CD45 exon A is the cause of variant CD45RA splicing in humans

The leukocyte common antigen (CD45) is alternatively spliced, generating various isoforms expressed on hemopoietic cells. The splicing pattern of CD45 in T cells is altered in some individuals who show abnormal expression of high molecular weight isoforms containing exon A. The variant splicing patt...

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Veröffentlicht in:	European journal of immunology 1998-01, Vol.28 (1), p.22-29
Hauptverfasser:	Zilch, Christian F., Walker, Andrew M., Timón, Marcos, Goff, Lindsey K., Wallace, Diana L., Beverley, Peter C. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Alternative splicing Animals CD45 CHO Cells COS Cells Cricetinae Cricetulus Exons - genetics Genes, Synthetic HeLa Cells Humans Hybrid Cells Leukocyte Common Antigens - biosynthesis Leukocyte Common Antigens - genetics Mice Minigene Molecular Weight Mutagenesis, Site-Directed Point Mutation Polymerase Chain Reaction RNA Splicing RNA, Messenger - genetics RNA, Messenger - metabolism Somatic cell hybrid T cell T-Lymphocytes - metabolism Transfection
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