Induction of clinical remission in T-large granular lymphocyte leukemia with cyclosporin A, monitored by use of immunophenotyping with Vβ antibodies
A 54-year-old woman presented with a severe autoimmune anemia, thrombocytopenia, neutropenia (Evans’ syndrome), and CD8+lymphocytosis, without signs of lymphadenopathy or splenomegaly. A diagnosis of T cell large granular lymphocyte (T-LGL) leukemia was made, based on cytomorphology, the typical CD3...
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| Veröffentlicht in: | Leukemia 1998-02, Vol.12 (2), p.150-154 |
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| creator | BRINKMAN, K VAN DONGEN, J. J. M VAN LOM, K GROENEVELD, K MISERE, J. F. M. M VAN DER HEUL, C |
| description | A 54-year-old woman presented with a severe autoimmune anemia, thrombocytopenia, neutropenia (Evans’ syndrome), and CD8+lymphocytosis, without signs of lymphadenopathy or splenomegaly. A diagnosis of T cell large granular lymphocyte (T-LGL) leukemia was made, based on cytomorphology, the typical CD3+/CD4−/CD8+/CD16+/CD56−/CD57−/HLA-DR± immunophenotype of the lymphocytosis (9 × 109/l), and biallelic clonally rearranged T cell receptor β (TCRβ) genes. Clonality of the TCRαβ+ T-LGL was also demonstrated with a panel of antibodies against variable domains of TCRβ chains, which showed single Vβ7.1 expression on the CD3+ T-lymphocytes. After treatment failure with corticosteroids, splenectomy, and cyclophosphamide, respectively, a complete clinical remission was induced and sustained with cyclosporin A. Vβ7.1/CD8/CD3 triple immunofluorescence stainings appeared to be valuable for titrating the cyclosporin A dosage by monitoring the T-LGL cells during treatment. |
| doi_str_mv | 10.1038/sj.leu.2400907 |
| format | Article |
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J. M ; VAN LOM, K ; GROENEVELD, K ; MISERE, J. F. M. M ; VAN DER HEUL, C</creator><creatorcontrib>BRINKMAN, K ; VAN DONGEN, J. J. M ; VAN LOM, K ; GROENEVELD, K ; MISERE, J. F. M. M ; VAN DER HEUL, C</creatorcontrib><description>A 54-year-old woman presented with a severe autoimmune anemia, thrombocytopenia, neutropenia (Evans’ syndrome), and CD8+lymphocytosis, without signs of lymphadenopathy or splenomegaly. A diagnosis of T cell large granular lymphocyte (T-LGL) leukemia was made, based on cytomorphology, the typical CD3+/CD4−/CD8+/CD16+/CD56−/CD57−/HLA-DR± immunophenotype of the lymphocytosis (9 × 109/l), and biallelic clonally rearranged T cell receptor β (TCRβ) genes. Clonality of the TCRαβ+ T-LGL was also demonstrated with a panel of antibodies against variable domains of TCRβ chains, which showed single Vβ7.1 expression on the CD3+ T-lymphocytes. After treatment failure with corticosteroids, splenectomy, and cyclophosphamide, respectively, a complete clinical remission was induced and sustained with cyclosporin A. Vβ7.1/CD8/CD3 triple immunofluorescence stainings appeared to be valuable for titrating the cyclosporin A dosage by monitoring the T-LGL cells during treatment.</description><identifier>ISSN: 0887-6924</identifier><identifier>EISSN: 1476-5551</identifier><identifier>DOI: 10.1038/sj.leu.2400907</identifier><identifier>CODEN: LEUKED</identifier><language>eng</language><publisher>London: Nature Publishing</publisher><subject>Anemia ; Antibodies ; Biological and medical sciences ; CD16 antigen ; CD3 antigen ; CD4 antigen ; CD56 antigen ; CD57 antigen ; CD8 antigen ; Corticoids ; Corticosteroids ; Cyclophosphamide ; Cyclosporin A ; Health services ; Histocompatibility antigen HLA ; Immunofluorescence ; Immunomodulators ; Leukemia ; Lymphadenopathy ; Lymphocytes ; Lymphocytes T ; Lymphocytosis ; Medical sciences ; Neutropenia ; Pharmacology. Drug treatments ; Remission ; Remission (Medicine) ; Splenectomy ; Splenomegaly ; T cell receptors ; Thrombocytopenia</subject><ispartof>Leukemia, 1998-02, Vol.12 (2), p.150-154</ispartof><rights>1998 INIST-CNRS</rights><rights>Macmillan Publishers Limited 1998.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-62deb60183e0f26ff77ef862d21ce80dcb580221a54eac399ea06bbcd6e719343</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,776,780,785,786,23911,23912,25120,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2164957$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>BRINKMAN, K</creatorcontrib><creatorcontrib>VAN DONGEN, J. J. M</creatorcontrib><creatorcontrib>VAN LOM, K</creatorcontrib><creatorcontrib>GROENEVELD, K</creatorcontrib><creatorcontrib>MISERE, J. F. M. M</creatorcontrib><creatorcontrib>VAN DER HEUL, C</creatorcontrib><title>Induction of clinical remission in T-large granular lymphocyte leukemia with cyclosporin A, monitored by use of immunophenotyping with Vβ antibodies</title><title>Leukemia</title><description>A 54-year-old woman presented with a severe autoimmune anemia, thrombocytopenia, neutropenia (Evans’ syndrome), and CD8+lymphocytosis, without signs of lymphadenopathy or splenomegaly. A diagnosis of T cell large granular lymphocyte (T-LGL) leukemia was made, based on cytomorphology, the typical CD3+/CD4−/CD8+/CD16+/CD56−/CD57−/HLA-DR± immunophenotype of the lymphocytosis (9 × 109/l), and biallelic clonally rearranged T cell receptor β (TCRβ) genes. Clonality of the TCRαβ+ T-LGL was also demonstrated with a panel of antibodies against variable domains of TCRβ chains, which showed single Vβ7.1 expression on the CD3+ T-lymphocytes. After treatment failure with corticosteroids, splenectomy, and cyclophosphamide, respectively, a complete clinical remission was induced and sustained with cyclosporin A. Vβ7.1/CD8/CD3 triple immunofluorescence stainings appeared to be valuable for titrating the cyclosporin A dosage by monitoring the T-LGL cells during treatment.</description><subject>Anemia</subject><subject>Antibodies</subject><subject>Biological and medical sciences</subject><subject>CD16 antigen</subject><subject>CD3 antigen</subject><subject>CD4 antigen</subject><subject>CD56 antigen</subject><subject>CD57 antigen</subject><subject>CD8 antigen</subject><subject>Corticoids</subject><subject>Corticosteroids</subject><subject>Cyclophosphamide</subject><subject>Cyclosporin A</subject><subject>Health services</subject><subject>Histocompatibility antigen HLA</subject><subject>Immunofluorescence</subject><subject>Immunomodulators</subject><subject>Leukemia</subject><subject>Lymphadenopathy</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Lymphocytosis</subject><subject>Medical sciences</subject><subject>Neutropenia</subject><subject>Pharmacology. Drug treatments</subject><subject>Remission</subject><subject>Remission (Medicine)</subject><subject>Splenectomy</subject><subject>Splenomegaly</subject><subject>T cell receptors</subject><subject>Thrombocytopenia</subject><issn>0887-6924</issn><issn>1476-5551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNpdkUtu2zAQhomiAeom3XZNIEVXkUtSIiUtjSAPAwa6SbolKGpk06VIhZQQ6CC9SA-SM4WCjS66IjHz_fP4B6GvlKwpyasf8bi2MK1ZQUhNyg9oRYtSZJxz-hGtSFWVmahZ8Ql9jvFIyJIUK_Rn69pJj8Y77DusrXFGK4sD9CbGJWocfsqsCnvA-6DclL7Yzv1w8HoeAaeOvxOr8KsZD1jP2vo4-JBUmxvce2dGH6DFzYynCEsL0_eT88MBnB_nwbj9Sfnr7S9WbjSNbw3EK3TRKRvhy_m9RM_3d0-3j9nu58P2drPLdM6LMROshUYQWuVAOia6riyhq1KUUQ0VaXXDK8IYVbwApfO6BkVE0-hWQEnrvMgv0fdT3SH4lwniKNPaGqxVDvwUJRU5p6QUCbz-Dzz6Kbg0m2Si4KKmhC_U-kTp4GMM0MkhmF6FWVIilxvJeJTJMXm-URJ8O5dVMdneJYO1if9UjIqi5mX-Dobhlp0</recordid><startdate>19980201</startdate><enddate>19980201</enddate><creator>BRINKMAN, K</creator><creator>VAN DONGEN, J. J. M</creator><creator>VAN LOM, K</creator><creator>GROENEVELD, K</creator><creator>MISERE, J. F. M. M</creator><creator>VAN DER HEUL, C</creator><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope></search><sort><creationdate>19980201</creationdate><title>Induction of clinical remission in T-large granular lymphocyte leukemia with cyclosporin A, monitored by use of immunophenotyping with Vβ antibodies</title><author>BRINKMAN, K ; VAN DONGEN, J. J. M ; VAN LOM, K ; GROENEVELD, K ; MISERE, J. F. M. M ; VAN DER HEUL, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-62deb60183e0f26ff77ef862d21ce80dcb580221a54eac399ea06bbcd6e719343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Anemia</topic><topic>Antibodies</topic><topic>Biological and medical sciences</topic><topic>CD16 antigen</topic><topic>CD3 antigen</topic><topic>CD4 antigen</topic><topic>CD56 antigen</topic><topic>CD57 antigen</topic><topic>CD8 antigen</topic><topic>Corticoids</topic><topic>Corticosteroids</topic><topic>Cyclophosphamide</topic><topic>Cyclosporin A</topic><topic>Health services</topic><topic>Histocompatibility antigen HLA</topic><topic>Immunofluorescence</topic><topic>Immunomodulators</topic><topic>Leukemia</topic><topic>Lymphadenopathy</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Lymphocytosis</topic><topic>Medical sciences</topic><topic>Neutropenia</topic><topic>Pharmacology. 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J. M</au><au>VAN LOM, K</au><au>GROENEVELD, K</au><au>MISERE, J. F. M. M</au><au>VAN DER HEUL, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Induction of clinical remission in T-large granular lymphocyte leukemia with cyclosporin A, monitored by use of immunophenotyping with Vβ antibodies</atitle><jtitle>Leukemia</jtitle><date>1998-02-01</date><risdate>1998</risdate><volume>12</volume><issue>2</issue><spage>150</spage><epage>154</epage><pages>150-154</pages><issn>0887-6924</issn><eissn>1476-5551</eissn><coden>LEUKED</coden><abstract>A 54-year-old woman presented with a severe autoimmune anemia, thrombocytopenia, neutropenia (Evans’ syndrome), and CD8+lymphocytosis, without signs of lymphadenopathy or splenomegaly. A diagnosis of T cell large granular lymphocyte (T-LGL) leukemia was made, based on cytomorphology, the typical CD3+/CD4−/CD8+/CD16+/CD56−/CD57−/HLA-DR± immunophenotype of the lymphocytosis (9 × 109/l), and biallelic clonally rearranged T cell receptor β (TCRβ) genes. Clonality of the TCRαβ+ T-LGL was also demonstrated with a panel of antibodies against variable domains of TCRβ chains, which showed single Vβ7.1 expression on the CD3+ T-lymphocytes. After treatment failure with corticosteroids, splenectomy, and cyclophosphamide, respectively, a complete clinical remission was induced and sustained with cyclosporin A. Vβ7.1/CD8/CD3 triple immunofluorescence stainings appeared to be valuable for titrating the cyclosporin A dosage by monitoring the T-LGL cells during treatment.</abstract><cop>London</cop><pub>Nature Publishing</pub><doi>10.1038/sj.leu.2400907</doi><tpages>5</tpages></addata></record> |
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| subjects | Anemia Antibodies Biological and medical sciences CD16 antigen CD3 antigen CD4 antigen CD56 antigen CD57 antigen CD8 antigen Corticoids Corticosteroids Cyclophosphamide Cyclosporin A Health services Histocompatibility antigen HLA Immunofluorescence Immunomodulators Leukemia Lymphadenopathy Lymphocytes Lymphocytes T Lymphocytosis Medical sciences Neutropenia Pharmacology. Drug treatments Remission Remission (Medicine) Splenectomy Splenomegaly T cell receptors Thrombocytopenia |
| title | Induction of clinical remission in T-large granular lymphocyte leukemia with cyclosporin A, monitored by use of immunophenotyping with Vβ antibodies |
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