A TEAD1/p65 complex regulates the eutherian-conserved MnSOD intronic enhancer, eRNA transcription and the innate immune response

Manganese superoxide dismutase (MnSOD), a critical anti-oxidant enzyme, detoxifies the mitochondrial-derived reactive oxygen species, superoxide, elicited through normal respiration or the inflammatory response. Proinflammatory stimuli induce MnSOD gene expression through a eutherian-conserved, intr...

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Veröffentlicht in:	Biochimica et biophysica acta 2014-11, Vol.1839 (11), p.1205-1216
Hauptverfasser:	Chokas, Ann L., Bickford, Justin S., Barilovits, Sarah J., Rogers, Richard J., Qiu, Xiaolei, Newsom, Kimberly J., Beachy, Dawn E., Nick, Harry S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Cells, Cultured DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Enhancer Elements, Genetic - genetics Enhancer-derived RNA (eRNA) Gene Expression Regulation Humans Immunity, Innate - genetics Intronic enhancer Introns Manganese superoxide dismutase (MnSOD) Molecular Sequence Data Nuclear Proteins - metabolism Nuclear Proteins - physiology p65 Protein Binding Rats RNA - genetics RNA - metabolism Superoxide Dismutase - genetics TEAD1 Transcription Factor RelA - metabolism Transcription Factor RelA - physiology Transcription Factors - metabolism Transcription Factors - physiology
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