The significance of immunohistochemical expression of merlin, Ki-67, and p53 in meningiomas
Meningiomas are one of the most common CNS tumors whose appearance is closely linked to NF2 gene product merlin. Tumor markers Ki-67 and p53 play established role in tumor progression which should be analyzed in close association with merlin expression. The aim of this study was to investigate the i...
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| Veröffentlicht in: | Applied immunohistochemistry & molecular morphology 2014-01, Vol.22 (1), p.46-49 |
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| creator | Pavelin, Sanda Bečić, Kristijan Forempoher, Gea Tomić, Snježana Capkun, Vesna Drmić-Hofman, Irena Mrklić, Ivana Lušić, Ivo Pogorelić, Zenon |
| description | Meningiomas are one of the most common CNS tumors whose appearance is closely linked to NF2 gene product merlin. Tumor markers Ki-67 and p53 play established role in tumor progression which should be analyzed in close association with merlin expression. The aim of this study was to investigate the immunohistochemical expression of merlin in meningiomas, correlation with Ki-67 and p53, and to determine the association of these results with histologic grade and subtype. The histologic sections of 170 patients with totally resected meningiomas, between January 2000 and December 2010, were classified according to WHO, immunohistochemically stained for Ki-67, p53, and merlin, and analyzed using light microscope. Ki-67 median was 5.6 times higher in group of patients with negative merlin than in those with positive merlin (P=0.05). Statistically significant correlation of merlin with p53 was found (P |
| doi_str_mv | 10.1097/PAI.0b013e318289f490 |
| format | Article |
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Tumor markers Ki-67 and p53 play established role in tumor progression which should be analyzed in close association with merlin expression. The aim of this study was to investigate the immunohistochemical expression of merlin in meningiomas, correlation with Ki-67 and p53, and to determine the association of these results with histologic grade and subtype. The histologic sections of 170 patients with totally resected meningiomas, between January 2000 and December 2010, were classified according to WHO, immunohistochemically stained for Ki-67, p53, and merlin, and analyzed using light microscope. Ki-67 median was 5.6 times higher in group of patients with negative merlin than in those with positive merlin (P=0.05). Statistically significant correlation of merlin with p53 was found (P<0.001). Merlin expression between 2 combined groups (meningothelial/secretory and fibroblastic/transitional) was statistically significant (P=0.002). By comparing merlin expression and p53 levels, statistically significant difference was found (P=0.017). In the group with positive merlin and negative p53 as well as positive merlin and low p53, meningothelial/secretory subtypes of meningiomas were more common. In combination of negative merlin and negative p53 as well as negative merlin and high p53, there were more meningiomas of fibroblastic/transitional subtype. There was no statistically significant correlation between merlin and tumor grade (P=0.420). There is undeniable influence of merlin on the development and the proliferative ability of meningioma subtypes. Significant role of p53 pathway was confirmed.</description><identifier>ISSN: 1541-2016</identifier><identifier>EISSN: 1533-4058</identifier><identifier>DOI: 10.1097/PAI.0b013e318289f490</identifier><identifier>PMID: 23455188</identifier><language>eng</language><publisher>United States</publisher><subject>Humans ; Immunohistochemistry ; Ki-67 Antigen - metabolism ; Meningeal Neoplasms - metabolism ; Meningioma - metabolism ; Neurofibromin 2 - metabolism ; Tumor Suppressor Protein p53 - metabolism</subject><ispartof>Applied immunohistochemistry & molecular morphology, 2014-01, Vol.22 (1), p.46-49</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-c1e0de7df11d69d3c703232eadbccbb24d8755dc8cc3ab505a10426725fed1d53</citedby><cites>FETCH-LOGICAL-c406t-c1e0de7df11d69d3c703232eadbccbb24d8755dc8cc3ab505a10426725fed1d53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23455188$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pavelin, Sanda</creatorcontrib><creatorcontrib>Bečić, Kristijan</creatorcontrib><creatorcontrib>Forempoher, Gea</creatorcontrib><creatorcontrib>Tomić, Snježana</creatorcontrib><creatorcontrib>Capkun, Vesna</creatorcontrib><creatorcontrib>Drmić-Hofman, Irena</creatorcontrib><creatorcontrib>Mrklić, Ivana</creatorcontrib><creatorcontrib>Lušić, Ivo</creatorcontrib><creatorcontrib>Pogorelić, Zenon</creatorcontrib><title>The significance of immunohistochemical expression of merlin, Ki-67, and p53 in meningiomas</title><title>Applied immunohistochemistry & molecular morphology</title><addtitle>Appl Immunohistochem Mol Morphol</addtitle><description>Meningiomas are one of the most common CNS tumors whose appearance is closely linked to NF2 gene product merlin. Tumor markers Ki-67 and p53 play established role in tumor progression which should be analyzed in close association with merlin expression. The aim of this study was to investigate the immunohistochemical expression of merlin in meningiomas, correlation with Ki-67 and p53, and to determine the association of these results with histologic grade and subtype. The histologic sections of 170 patients with totally resected meningiomas, between January 2000 and December 2010, were classified according to WHO, immunohistochemically stained for Ki-67, p53, and merlin, and analyzed using light microscope. Ki-67 median was 5.6 times higher in group of patients with negative merlin than in those with positive merlin (P=0.05). Statistically significant correlation of merlin with p53 was found (P<0.001). Merlin expression between 2 combined groups (meningothelial/secretory and fibroblastic/transitional) was statistically significant (P=0.002). By comparing merlin expression and p53 levels, statistically significant difference was found (P=0.017). In the group with positive merlin and negative p53 as well as positive merlin and low p53, meningothelial/secretory subtypes of meningiomas were more common. In combination of negative merlin and negative p53 as well as negative merlin and high p53, there were more meningiomas of fibroblastic/transitional subtype. There was no statistically significant correlation between merlin and tumor grade (P=0.420). There is undeniable influence of merlin on the development and the proliferative ability of meningioma subtypes. Significant role of p53 pathway was confirmed.</description><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Ki-67 Antigen - metabolism</subject><subject>Meningeal Neoplasms - metabolism</subject><subject>Meningioma - metabolism</subject><subject>Neurofibromin 2 - metabolism</subject><subject>Tumor Suppressor Protein p53 - metabolism</subject><issn>1541-2016</issn><issn>1533-4058</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1Lw0AQxRdRbK3-ByI5emh0Z7-SHEvxo1jQQz15CJvdSbuSbGK2Af3vTWn14MXTG3i_NwPzCLkEegM0S25fZosbWlDgyCFlaVaKjB6RMUjOY0FlerybBcSMghqRsxDeKWWMC3FKRoNICWk6Jm-rDUbBrb0rndHeYNSUkavr3jcbF7aN2WA9GFWEn22HIbjG74gau8r5afTkYpVMI-1t1EoeOT843vm1a2odzslJqauAFwedkNf7u9X8MV4-Pyzms2VsBFXb2ABSi4ktAazKLDcJ5Ywz1LYwpiiYsGkipTWpMVwXkkoNVDCVMFmiBSv5hFzv97Zd89Fj2Oa1CwarSnts-pCD4pLyVKrkf1SoRHGlAAZU7FHTNSF0WOZt52rdfeVA810D-dBA_reBIXZ1uNAXNdrf0M_L-TfKMYHo</recordid><startdate>201401</startdate><enddate>201401</enddate><creator>Pavelin, Sanda</creator><creator>Bečić, Kristijan</creator><creator>Forempoher, Gea</creator><creator>Tomić, Snježana</creator><creator>Capkun, Vesna</creator><creator>Drmić-Hofman, Irena</creator><creator>Mrklić, Ivana</creator><creator>Lušić, Ivo</creator><creator>Pogorelić, Zenon</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope></search><sort><creationdate>201401</creationdate><title>The significance of immunohistochemical expression of merlin, Ki-67, and p53 in meningiomas</title><author>Pavelin, Sanda ; Bečić, Kristijan ; Forempoher, Gea ; Tomić, Snježana ; Capkun, Vesna ; Drmić-Hofman, Irena ; Mrklić, Ivana ; Lušić, Ivo ; Pogorelić, Zenon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-c1e0de7df11d69d3c703232eadbccbb24d8755dc8cc3ab505a10426725fed1d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Ki-67 Antigen - metabolism</topic><topic>Meningeal Neoplasms - metabolism</topic><topic>Meningioma - metabolism</topic><topic>Neurofibromin 2 - metabolism</topic><topic>Tumor Suppressor Protein p53 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pavelin, Sanda</creatorcontrib><creatorcontrib>Bečić, Kristijan</creatorcontrib><creatorcontrib>Forempoher, Gea</creatorcontrib><creatorcontrib>Tomić, Snježana</creatorcontrib><creatorcontrib>Capkun, Vesna</creatorcontrib><creatorcontrib>Drmić-Hofman, Irena</creatorcontrib><creatorcontrib>Mrklić, Ivana</creatorcontrib><creatorcontrib>Lušić, Ivo</creatorcontrib><creatorcontrib>Pogorelić, Zenon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Applied immunohistochemistry & molecular morphology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pavelin, Sanda</au><au>Bečić, Kristijan</au><au>Forempoher, Gea</au><au>Tomić, Snježana</au><au>Capkun, Vesna</au><au>Drmić-Hofman, Irena</au><au>Mrklić, Ivana</au><au>Lušić, Ivo</au><au>Pogorelić, Zenon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The significance of immunohistochemical expression of merlin, Ki-67, and p53 in meningiomas</atitle><jtitle>Applied immunohistochemistry & molecular morphology</jtitle><addtitle>Appl Immunohistochem Mol Morphol</addtitle><date>2014-01</date><risdate>2014</risdate><volume>22</volume><issue>1</issue><spage>46</spage><epage>49</epage><pages>46-49</pages><issn>1541-2016</issn><eissn>1533-4058</eissn><abstract>Meningiomas are one of the most common CNS tumors whose appearance is closely linked to NF2 gene product merlin. Tumor markers Ki-67 and p53 play established role in tumor progression which should be analyzed in close association with merlin expression. The aim of this study was to investigate the immunohistochemical expression of merlin in meningiomas, correlation with Ki-67 and p53, and to determine the association of these results with histologic grade and subtype. The histologic sections of 170 patients with totally resected meningiomas, between January 2000 and December 2010, were classified according to WHO, immunohistochemically stained for Ki-67, p53, and merlin, and analyzed using light microscope. Ki-67 median was 5.6 times higher in group of patients with negative merlin than in those with positive merlin (P=0.05). Statistically significant correlation of merlin with p53 was found (P<0.001). Merlin expression between 2 combined groups (meningothelial/secretory and fibroblastic/transitional) was statistically significant (P=0.002). By comparing merlin expression and p53 levels, statistically significant difference was found (P=0.017). In the group with positive merlin and negative p53 as well as positive merlin and low p53, meningothelial/secretory subtypes of meningiomas were more common. In combination of negative merlin and negative p53 as well as negative merlin and high p53, there were more meningiomas of fibroblastic/transitional subtype. There was no statistically significant correlation between merlin and tumor grade (P=0.420). There is undeniable influence of merlin on the development and the proliferative ability of meningioma subtypes. Significant role of p53 pathway was confirmed.</abstract><cop>United States</cop><pmid>23455188</pmid><doi>10.1097/PAI.0b013e318289f490</doi><tpages>4</tpages></addata></record> |
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| subjects | Humans Immunohistochemistry Ki-67 Antigen - metabolism Meningeal Neoplasms - metabolism Meningioma - metabolism Neurofibromin 2 - metabolism Tumor Suppressor Protein p53 - metabolism |
| title | The significance of immunohistochemical expression of merlin, Ki-67, and p53 in meningiomas |
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