Structure of Chitosan Determines Its Interactions with Mucin

Synthetic and natural mucoadhesive biomaterials in optimized galenical formulations are potentially useful for the transmucosal delivery of active ingredients to improve their localized and prolonged effects. Chitosans (CS) have potent mucoadhesive characteristics, but the exact mechanisms underpinn...

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Veröffentlicht in:	Biomacromolecules 2014-10, Vol.15 (10), p.3550-3558
Hauptverfasser:	Menchicchi, B, Fuenzalida, J. P, Bobbili, Kishore Babu, Hensel, A, Swamy, Musti J, Goycoolea, F. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Applied sciences Biological and medical sciences Chemistry, Pharmaceutical - methods Chitosan - chemistry Chitosan - metabolism Drug Delivery Systems - methods Exact sciences and technology Fundamental and applied biological sciences. Psychology Gastric Mucins - metabolism General pharmacology Glycoproteins Helicobacter pylori Hydrogen Bonding Hydrophobic and Hydrophilic Interactions Medical sciences Mucins - chemistry Mucins - metabolism Nanostructures - chemistry Natural polymers Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physicochemistry of polymers Proteins Starch and polysaccharides Static Electricity Swine
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