Sex-dependent effects of maternal separation on plasma corticosterone and brain monoamines in response to chronic ethanol administration

Highlights • Long maternal separation (LMS) does not alter motor activity or corticosterone levels. • In LMS females, chronic EtOH increases DA and 5-HT levels in frontal cortex. • In LMS males, chronic EtOH increased levels of hippocampal monoamines and metabolites. • Corticosterone response to chr...

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Veröffentlicht in:	Neuroscience 2013-12, Vol.253, p.55-66
Hauptverfasser:	Kawakami, S.E, Quadros, I.M.H, Machado, R.B, Suchecki, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Addictive behaviors Adult and adolescent clinical studies alcohol Alcoholism Alcoholism and acute alcohol poisoning Analysis of Variance Animals Animals, Newborn behavioral sensitization Biogenic Monoamines - metabolism Biological and medical sciences Brain - drug effects Brain - metabolism brain monoamines Central Nervous System Depressants - administration & dosage corticosterone Corticosterone - blood Drug Administration Schedule early life stress Ethanol - administration & dosage Female Male Maternal Deprivation Medical sciences Mice Motor Activity - drug effects Neurology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Sex Characteristics sex differences Time Factors Toxicology
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Zusammenfassung:	Highlights • Long maternal separation (LMS) does not alter motor activity or corticosterone levels. • In LMS females, chronic EtOH increases DA and 5-HT levels in frontal cortex. • In LMS males, chronic EtOH increased levels of hippocampal monoamines and metabolites. • Corticosterone response to chronic EtOH was higher in LMS males than in AFR counterparts.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.08.031