Gastric juice long noncoding RNA used as a tumor marker for screening gastric cancer
BACKGROUND Long noncoding RNAs (lncRNAs) play a crucial role in tumorigenesis. However, the value of lncRNAs in the diagnosis of gastric cancer remains unknown. To identify whether lncRNA‐AA174084 is a potential marker for the early diagnosis of gastric cancer (GC), the authors investigated its leve...
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| Veröffentlicht in: | Cancer 2014-11, Vol.120 (21), p.3320-3328 |
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| container_title | Cancer |
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| creator | Shao, Yongfu Ye, Meng Jiang, Xiaoming Sun, Weiliang Ding, Xiaoyun Liu, Zhong Ye, Guoliang Zhang, Xinjun Xiao, Bingxiu Guo, Junming |
| description | BACKGROUND
Long noncoding RNAs (lncRNAs) play a crucial role in tumorigenesis. However, the value of lncRNAs in the diagnosis of gastric cancer remains unknown. To identify whether lncRNA‐AA174084 is a potential marker for the early diagnosis of gastric cancer (GC), the authors investigated its levels in tissues, blood, and gastric juices from patients with various stage of gastric tumorigenesis.
METHODS
Total RNA in 860 specimens from patients and healthy controls was extracted. Levels of AA174084 in 134 paired GC tissues, 127 gastric mucosal tissues, 335 plasma samples, and 130 gastric juice samples at each stage of gastric tumorigenesis were measured using real‐time reverse transcriptase‐polymerase chain reaction analysis. The potential association between AA174084 levels and patients' clinicopathologic features were analyzed. A receiver operating characteristic (ROC) curve was constructed for differentiating GC patients from controls.
RESULTS
Expression levels of AA174084 were down‐regulated significantly in 95 of 134 GC tissues (71%) compared with the levels in paired, adjacent, normal tissues (P < .001). AA174084 levels had significant, negative correlations with age (P = .031), Borrmann type (P = .016), and perineural invasion (P = .032). Plasma AA174084 levels in patients with GC dropped markedly on day 15 after surgery compared with preoperative levels (P < .001) and were associated with invasion (P = .049) and lymphatic metastasis (P = .042). AA174084 levels in gastric juice from patients with GC were significantly higher than the levels in normal mucosa or in patients with minimal gastritis, gastric ulcers, and atrophic gastritis (P < .001). The area under ROC was up to 0.848 (P < .001).
CONCLUSIONS
AA174084 may have potential as marker for the early diagnosis of GC. Cancer 2014;120:3320–3328. © 2014 American Cancer Society.
Long noncoding RNAs (lncRNAs) stably exist in gastric juice and can be detected using real‐time quantitative reverse transcription‐polymerase chain reaction analysis. Some lncRNAs, such as AA174084 in gastric juice, can be used as biomarkers for the detection of gastric cancer with satisfactory specificity and sensitivity. |
| doi_str_mv | 10.1002/cncr.28882 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1635035700</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1635035700</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4942-d347f84e712f934c93ac7fa2c3e052ad67428bb8d67a33e95a7fc24d8f4bd0ab3</originalsourceid><addsrcrecordid>eNqNkF1LwzAUhoMobk5v_AGSG0GEzny26eUoOoUxYUzwrqRpMjr7MZMV2b83tVXvxKvzHnh4D-cB4BKjKUaI3Kla2SkRQpAjMMYojgKEGTkGY4SQCDijryNw5tzWrxHh9BSMCItFiBgeg_Vcur0tFNy2hdKwbOoNrJtaNXnh02o5g63TOZQOSrhvq8bCSto3baHx0Smrdd2Bm6FFyVppew5OjCydvhjmBLw83K-Tx2DxPH9KZotAsZiRIKcsMoLpCBMTU6ZiKlVkJFFUI05kHkaMiCwTPkhKdcxlZBRhuTAsy5HM6ATc9L0727y32u3TqnBKl6WsddO6FIeUI8ojhP6BYk5CEmPu0dseVbZxzmqT7mzhvz6kGKWd8LQTnn4J9_DV0Ntmlc5_0G_DHrgeAOmULI31hgr3y4mYUcq6ItxzH0WpD3-cTJNlsuqPfwLq2Zdk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1615262915</pqid></control><display><type>article</type><title>Gastric juice long noncoding RNA used as a tumor marker for screening gastric cancer</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Online Library Free Content</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Shao, Yongfu ; Ye, Meng ; Jiang, Xiaoming ; Sun, Weiliang ; Ding, Xiaoyun ; Liu, Zhong ; Ye, Guoliang ; Zhang, Xinjun ; Xiao, Bingxiu ; Guo, Junming</creator><creatorcontrib>Shao, Yongfu ; Ye, Meng ; Jiang, Xiaoming ; Sun, Weiliang ; Ding, Xiaoyun ; Liu, Zhong ; Ye, Guoliang ; Zhang, Xinjun ; Xiao, Bingxiu ; Guo, Junming</creatorcontrib><description>BACKGROUND
Long noncoding RNAs (lncRNAs) play a crucial role in tumorigenesis. However, the value of lncRNAs in the diagnosis of gastric cancer remains unknown. To identify whether lncRNA‐AA174084 is a potential marker for the early diagnosis of gastric cancer (GC), the authors investigated its levels in tissues, blood, and gastric juices from patients with various stage of gastric tumorigenesis.
METHODS
Total RNA in 860 specimens from patients and healthy controls was extracted. Levels of AA174084 in 134 paired GC tissues, 127 gastric mucosal tissues, 335 plasma samples, and 130 gastric juice samples at each stage of gastric tumorigenesis were measured using real‐time reverse transcriptase‐polymerase chain reaction analysis. The potential association between AA174084 levels and patients' clinicopathologic features were analyzed. A receiver operating characteristic (ROC) curve was constructed for differentiating GC patients from controls.
RESULTS
Expression levels of AA174084 were down‐regulated significantly in 95 of 134 GC tissues (71%) compared with the levels in paired, adjacent, normal tissues (P < .001). AA174084 levels had significant, negative correlations with age (P = .031), Borrmann type (P = .016), and perineural invasion (P = .032). Plasma AA174084 levels in patients with GC dropped markedly on day 15 after surgery compared with preoperative levels (P < .001) and were associated with invasion (P = .049) and lymphatic metastasis (P = .042). AA174084 levels in gastric juice from patients with GC were significantly higher than the levels in normal mucosa or in patients with minimal gastritis, gastric ulcers, and atrophic gastritis (P < .001). The area under ROC was up to 0.848 (P < .001).
CONCLUSIONS
AA174084 may have potential as marker for the early diagnosis of GC. Cancer 2014;120:3320–3328. © 2014 American Cancer Society.
Long noncoding RNAs (lncRNAs) stably exist in gastric juice and can be detected using real‐time quantitative reverse transcription‐polymerase chain reaction analysis. Some lncRNAs, such as AA174084 in gastric juice, can be used as biomarkers for the detection of gastric cancer with satisfactory specificity and sensitivity.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.28882</identifier><identifier>PMID: 24986041</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>Hoboken, NJ: Wiley-Blackwell</publisher><subject>AA174084 ; Adult ; Aged ; Biological and medical sciences ; biomarker ; Biomarkers, Tumor - biosynthesis ; Biomarkers, Tumor - blood ; Biomarkers, Tumor - genetics ; Early Detection of Cancer ; Female ; gastric cancer ; Gastric Juice ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; lncRNA ; long noncoding RNA ; Lymphatic Metastasis - genetics ; Male ; Medical sciences ; Middle Aged ; molecular diagnosis ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Neoplasm Staging ; RNA, Long Noncoding - biosynthesis ; RNA, Long Noncoding - blood ; RNA, Long Noncoding - genetics ; Stomach Neoplasms - blood ; Stomach Neoplasms - genetics ; Stomach Neoplasms - pathology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors</subject><ispartof>Cancer, 2014-11, Vol.120 (21), p.3320-3328</ispartof><rights>2014 American Cancer Society</rights><rights>2015 INIST-CNRS</rights><rights>2014 American Cancer Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4942-d347f84e712f934c93ac7fa2c3e052ad67428bb8d67a33e95a7fc24d8f4bd0ab3</citedby><cites>FETCH-LOGICAL-c4942-d347f84e712f934c93ac7fa2c3e052ad67428bb8d67a33e95a7fc24d8f4bd0ab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcncr.28882$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcncr.28882$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28943342$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24986041$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shao, Yongfu</creatorcontrib><creatorcontrib>Ye, Meng</creatorcontrib><creatorcontrib>Jiang, Xiaoming</creatorcontrib><creatorcontrib>Sun, Weiliang</creatorcontrib><creatorcontrib>Ding, Xiaoyun</creatorcontrib><creatorcontrib>Liu, Zhong</creatorcontrib><creatorcontrib>Ye, Guoliang</creatorcontrib><creatorcontrib>Zhang, Xinjun</creatorcontrib><creatorcontrib>Xiao, Bingxiu</creatorcontrib><creatorcontrib>Guo, Junming</creatorcontrib><title>Gastric juice long noncoding RNA used as a tumor marker for screening gastric cancer</title><title>Cancer</title><addtitle>Cancer</addtitle><description>BACKGROUND
Long noncoding RNAs (lncRNAs) play a crucial role in tumorigenesis. However, the value of lncRNAs in the diagnosis of gastric cancer remains unknown. To identify whether lncRNA‐AA174084 is a potential marker for the early diagnosis of gastric cancer (GC), the authors investigated its levels in tissues, blood, and gastric juices from patients with various stage of gastric tumorigenesis.
METHODS
Total RNA in 860 specimens from patients and healthy controls was extracted. Levels of AA174084 in 134 paired GC tissues, 127 gastric mucosal tissues, 335 plasma samples, and 130 gastric juice samples at each stage of gastric tumorigenesis were measured using real‐time reverse transcriptase‐polymerase chain reaction analysis. The potential association between AA174084 levels and patients' clinicopathologic features were analyzed. A receiver operating characteristic (ROC) curve was constructed for differentiating GC patients from controls.
RESULTS
Expression levels of AA174084 were down‐regulated significantly in 95 of 134 GC tissues (71%) compared with the levels in paired, adjacent, normal tissues (P < .001). AA174084 levels had significant, negative correlations with age (P = .031), Borrmann type (P = .016), and perineural invasion (P = .032). Plasma AA174084 levels in patients with GC dropped markedly on day 15 after surgery compared with preoperative levels (P < .001) and were associated with invasion (P = .049) and lymphatic metastasis (P = .042). AA174084 levels in gastric juice from patients with GC were significantly higher than the levels in normal mucosa or in patients with minimal gastritis, gastric ulcers, and atrophic gastritis (P < .001). The area under ROC was up to 0.848 (P < .001).
CONCLUSIONS
AA174084 may have potential as marker for the early diagnosis of GC. Cancer 2014;120:3320–3328. © 2014 American Cancer Society.
Long noncoding RNAs (lncRNAs) stably exist in gastric juice and can be detected using real‐time quantitative reverse transcription‐polymerase chain reaction analysis. Some lncRNAs, such as AA174084 in gastric juice, can be used as biomarkers for the detection of gastric cancer with satisfactory specificity and sensitivity.</description><subject>AA174084</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>biomarker</subject><subject>Biomarkers, Tumor - biosynthesis</subject><subject>Biomarkers, Tumor - blood</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Early Detection of Cancer</subject><subject>Female</subject><subject>gastric cancer</subject><subject>Gastric Juice</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>lncRNA</subject><subject>long noncoding RNA</subject><subject>Lymphatic Metastasis - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>molecular diagnosis</subject><subject>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</subject><subject>Neoplasm Staging</subject><subject>RNA, Long Noncoding - biosynthesis</subject><subject>RNA, Long Noncoding - blood</subject><subject>RNA, Long Noncoding - genetics</subject><subject>Stomach Neoplasms - blood</subject><subject>Stomach Neoplasms - genetics</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tumors</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1LwzAUhoMobk5v_AGSG0GEzny26eUoOoUxYUzwrqRpMjr7MZMV2b83tVXvxKvzHnh4D-cB4BKjKUaI3Kla2SkRQpAjMMYojgKEGTkGY4SQCDijryNw5tzWrxHh9BSMCItFiBgeg_Vcur0tFNy2hdKwbOoNrJtaNXnh02o5g63TOZQOSrhvq8bCSto3baHx0Smrdd2Bm6FFyVppew5OjCydvhjmBLw83K-Tx2DxPH9KZotAsZiRIKcsMoLpCBMTU6ZiKlVkJFFUI05kHkaMiCwTPkhKdcxlZBRhuTAsy5HM6ATc9L0727y32u3TqnBKl6WsddO6FIeUI8ojhP6BYk5CEmPu0dseVbZxzmqT7mzhvz6kGKWd8LQTnn4J9_DV0Ntmlc5_0G_DHrgeAOmULI31hgr3y4mYUcq6ItxzH0WpD3-cTJNlsuqPfwLq2Zdk</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>Shao, Yongfu</creator><creator>Ye, Meng</creator><creator>Jiang, Xiaoming</creator><creator>Sun, Weiliang</creator><creator>Ding, Xiaoyun</creator><creator>Liu, Zhong</creator><creator>Ye, Guoliang</creator><creator>Zhang, Xinjun</creator><creator>Xiao, Bingxiu</creator><creator>Guo, Junming</creator><general>Wiley-Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TM</scope></search><sort><creationdate>20141101</creationdate><title>Gastric juice long noncoding RNA used as a tumor marker for screening gastric cancer</title><author>Shao, Yongfu ; Ye, Meng ; Jiang, Xiaoming ; Sun, Weiliang ; Ding, Xiaoyun ; Liu, Zhong ; Ye, Guoliang ; Zhang, Xinjun ; Xiao, Bingxiu ; Guo, Junming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4942-d347f84e712f934c93ac7fa2c3e052ad67428bb8d67a33e95a7fc24d8f4bd0ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>AA174084</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>biomarker</topic><topic>Biomarkers, Tumor - biosynthesis</topic><topic>Biomarkers, Tumor - blood</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Early Detection of Cancer</topic><topic>Female</topic><topic>gastric cancer</topic><topic>Gastric Juice</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>lncRNA</topic><topic>long noncoding RNA</topic><topic>Lymphatic Metastasis - genetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>molecular diagnosis</topic><topic>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</topic><topic>Neoplasm Staging</topic><topic>RNA, Long Noncoding - biosynthesis</topic><topic>RNA, Long Noncoding - blood</topic><topic>RNA, Long Noncoding - genetics</topic><topic>Stomach Neoplasms - blood</topic><topic>Stomach Neoplasms - genetics</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shao, Yongfu</creatorcontrib><creatorcontrib>Ye, Meng</creatorcontrib><creatorcontrib>Jiang, Xiaoming</creatorcontrib><creatorcontrib>Sun, Weiliang</creatorcontrib><creatorcontrib>Ding, Xiaoyun</creatorcontrib><creatorcontrib>Liu, Zhong</creatorcontrib><creatorcontrib>Ye, Guoliang</creatorcontrib><creatorcontrib>Zhang, Xinjun</creatorcontrib><creatorcontrib>Xiao, Bingxiu</creatorcontrib><creatorcontrib>Guo, Junming</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Nucleic Acids Abstracts</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shao, Yongfu</au><au>Ye, Meng</au><au>Jiang, Xiaoming</au><au>Sun, Weiliang</au><au>Ding, Xiaoyun</au><au>Liu, Zhong</au><au>Ye, Guoliang</au><au>Zhang, Xinjun</au><au>Xiao, Bingxiu</au><au>Guo, Junming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gastric juice long noncoding RNA used as a tumor marker for screening gastric cancer</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2014-11-01</date><risdate>2014</risdate><volume>120</volume><issue>21</issue><spage>3320</spage><epage>3328</epage><pages>3320-3328</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>BACKGROUND
Long noncoding RNAs (lncRNAs) play a crucial role in tumorigenesis. However, the value of lncRNAs in the diagnosis of gastric cancer remains unknown. To identify whether lncRNA‐AA174084 is a potential marker for the early diagnosis of gastric cancer (GC), the authors investigated its levels in tissues, blood, and gastric juices from patients with various stage of gastric tumorigenesis.
METHODS
Total RNA in 860 specimens from patients and healthy controls was extracted. Levels of AA174084 in 134 paired GC tissues, 127 gastric mucosal tissues, 335 plasma samples, and 130 gastric juice samples at each stage of gastric tumorigenesis were measured using real‐time reverse transcriptase‐polymerase chain reaction analysis. The potential association between AA174084 levels and patients' clinicopathologic features were analyzed. A receiver operating characteristic (ROC) curve was constructed for differentiating GC patients from controls.
RESULTS
Expression levels of AA174084 were down‐regulated significantly in 95 of 134 GC tissues (71%) compared with the levels in paired, adjacent, normal tissues (P < .001). AA174084 levels had significant, negative correlations with age (P = .031), Borrmann type (P = .016), and perineural invasion (P = .032). Plasma AA174084 levels in patients with GC dropped markedly on day 15 after surgery compared with preoperative levels (P < .001) and were associated with invasion (P = .049) and lymphatic metastasis (P = .042). AA174084 levels in gastric juice from patients with GC were significantly higher than the levels in normal mucosa or in patients with minimal gastritis, gastric ulcers, and atrophic gastritis (P < .001). The area under ROC was up to 0.848 (P < .001).
CONCLUSIONS
AA174084 may have potential as marker for the early diagnosis of GC. Cancer 2014;120:3320–3328. © 2014 American Cancer Society.
Long noncoding RNAs (lncRNAs) stably exist in gastric juice and can be detected using real‐time quantitative reverse transcription‐polymerase chain reaction analysis. Some lncRNAs, such as AA174084 in gastric juice, can be used as biomarkers for the detection of gastric cancer with satisfactory specificity and sensitivity.</abstract><cop>Hoboken, NJ</cop><pub>Wiley-Blackwell</pub><pmid>24986041</pmid><doi>10.1002/cncr.28882</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | AA174084 Adult Aged Biological and medical sciences biomarker Biomarkers, Tumor - biosynthesis Biomarkers, Tumor - blood Biomarkers, Tumor - genetics Early Detection of Cancer Female gastric cancer Gastric Juice Gastroenterology. Liver. Pancreas. Abdomen Humans lncRNA long noncoding RNA Lymphatic Metastasis - genetics Male Medical sciences Middle Aged molecular diagnosis Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasm Staging RNA, Long Noncoding - biosynthesis RNA, Long Noncoding - blood RNA, Long Noncoding - genetics Stomach Neoplasms - blood Stomach Neoplasms - genetics Stomach Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | Gastric juice long noncoding RNA used as a tumor marker for screening gastric cancer |
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