Peptidoglycan and muramyl dipeptide from Staphylococcus aureus induce the expression of VEGF-A in human limbal fibroblasts with the participation of TLR2-NFκB and NOD2-EGFR

Background Keratitis caused by Staphylococcus aureus often leads to Vascular Endothelial Growth Factor (VEGF)-dependent neovascularization, but contribution of peptidoglycan (PGN), muramyl dipeptide (MDP) and lipoteichoic acid (LTA) from S. aureus to VEGF-dependent neovascularization has not been we...

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Veröffentlicht in:	Graefe's archive for clinical and experimental ophthalmology 2013, Vol.251 (1), p.53-62
Hauptverfasser:	Juárez–Verdayes, Marco Adán, Rodríguez–Martínez, Sandra, Cancino–Diaz, Mario E., Cancino–Diaz, Juan C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylmuramyl-Alanyl-Isoglutamine - chemistry Acetylmuramyl-Alanyl-Isoglutamine - pharmacology Basic Science Cells, Cultured Dose-Response Relationship, Drug Enzyme-Linked Immunosorbent Assay Eye Proteins - metabolism Fibroblasts - drug effects Fibroblasts - metabolism Flow Cytometry Gene Expression Regulation - physiology Humans Limbus Corneae - cytology Medicine Medicine & Public Health NF-kappa B - metabolism Nod2 Signaling Adaptor Protein - metabolism Ophthalmology Peptidoglycan - chemistry Peptidoglycan - pharmacology Receptor, Epidermal Growth Factor - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Staphylococcus aureus Staphylococcus aureus - chemistry Time Factors Toll-Like Receptor 2 - metabolism Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism
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