Phase II and III Clinical Studies of Diphtheria-Tetanus-Acellular Pertussis Vaccine Containing Inactivated Polio Vaccine Derived from Sabin Strains (DTaP-sIPV)

Background. Phase II and III clinical studies were conducted to evaluate immunogenicity and safety of a novel DTaP-IPV vaccine consisting of Sabin inactivated poliovirus vaccine (sIPV) and diphtheria-tetanus-acellular pertussis vaccine (DTaP). Methods. A Phase II study was conducted in 104 healthy i...

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Veröffentlicht in:	The Journal of infectious diseases 2013-07, Vol.208 (2), p.275-283
Hauptverfasser:	Okada, Kenji, Miyazaki, Chiaki, Kino, Yoichiro, Ozaki, Takao, Hirose, Mizuo, Ueda, Kohji
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Bacterial - immunology Antibodies, Viral - immunology Antibody Formation - immunology Biological and medical sciences Control groups Diphtheria - immunology Diphtheria - prevention & control Diphtheria-Tetanus-acellular Pertussis Vaccines - administration & dosage Diphtheria-Tetanus-acellular Pertussis Vaccines - immunology Diptheria pertussis tetanus vaccine Double-Blind Method Female Fundamental and applied biological sciences. Psychology Human viral diseases Humans Immune response Immunization Immunization Schedule Immunization, Secondary - methods Infant Infectious diseases Male Medical sciences Microbiology Neutralizing antibodies Oral poliovirus vaccine Poliomyelitis - immunology Poliomyelitis - prevention & control Poliovirus Poliovirus - immunology Poliovirus Vaccine, Inactivated - administration & dosage Poliovirus Vaccine, Inactivated - immunology Poliovirus Vaccine, Oral - administration & dosage Poliovirus Vaccine, Oral - immunology Secondary immunization Tetanus - immunology Tetanus - prevention & control Vaccination Vaccines, Combined - administration & dosage Vaccines, Combined - immunology Viral diseases Viral diseases of the nervous system VIRUSES Whooping cough Whooping Cough - immunology Whooping Cough - prevention & control
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