Pyrazole derivatives as potent inhibitors of c-Jun N-terminal kinase: Synthesis and SAR studies

A series of pyrazole amides was synthesized and screened for JNK-1 inhibitory and anti-inflammatory activity. Docking study was also performed. Mitogen activated protein kinases including c-Jun N-terminal kinase play an indispensable role in inflammatory diseases. Investigation of reported JNK-1 inh...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2014-11, Vol.22 (21), p.6209-6219
Hauptverfasser:	Doma, Anuradha, Kulkarni, Ravindra, Palakodety, Radhakrishna, Sastry, G. Narahari, Sridhara, Janardhan, Garlapati, Achaiah
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemistry Amides - pharmacology Amides - therapeutic use Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Edema - drug therapy Humans IC50 Inflammation JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors JNK Mitogen-Activated Protein Kinases - chemistry JNK Mitogen-Activated Protein Kinases - metabolism JNK-1 Molecular Docking Simulation Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Pyrazoles Pyrazoles - chemistry Pyrazoles - pharmacology Pyrazoles - therapeutic use Rats Structure-Activity Relationship
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