Novel strategy to boost oral anticoagulant activity of blood coagulation enzyme inhibitors based on biotransformation into hydrophilic conjugates

In this article, we propose a novel strategy towards discovery for orally active anticoagulants. This strategy is based on bioconversion from a nonamidine-type blood coagulation cascade inhibitor into the corresponding conjugate, which boosts ex vivo anticoagulant activity owing to an increase in hy...

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