Synthesis and pharmacological evaluation of optically pure, novel carbonyl guanidine derivatives as dual 5-HT sub(2B) and 5-HT sub(7) receptor antagonists

A series of 9-disubstituted N-(9H-fluorene-2-carbonyl)guanidine derivatives have been discovered as potent and orally active dual 5-HT sub(2B) and 5-HT sub(7) receptor antagonists. Upon screening several compounds, N-(diaminomethylene)-4',5'-dihydro-3'H-spiro[f luorene-9,2'-furan...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2014-11, Vol.22 (21), p.6026-6038
Hauptverfasser:	Moritomo, Ayako, Yamada, Hiroyoshi, Matsuzawa-Nomura, Takaho, Watanabe, Toshihiro, Itahana, Hirotsune, Oku, Makoto, Akuzawa, Shinobu, Okada, Minoru
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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