Inhibition of prolyl oligopeptidase increases the survival of alpha-synuclein overexpressing cells after rotenone exposure by reducing alpha-synuclein oligomers

•Rotenone induced α-synuclein (aSyn) aggregation in [A53T]aSyn overexpressing cells.•Prolyl oligopeptidase (PREP) inhibition reduced the levels of aSyn oligomers.•PREP inhibition decreased ROS production by reducing aSyn oligomers.•These effects of PREP inhibition led to increased cell survival. α-S...

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Veröffentlicht in:	Neuroscience letters 2014-11, Vol.583, p.37-42
Hauptverfasser:	Dokleja, Lana, Hannula, Mirva J., Myöhänen, Timo T.
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - genetics alpha-Synuclein - metabolism Autophagy Cell Line, Tumor Humans Mitochondria - metabolism Mutation Parkinson's disease Proline - analogs & derivatives Proline - pharmacology Protein Aggregates Protein misfolding Reactive oxygen species Reactive Oxygen Species - metabolism Rotenone - toxicity Serine Endopeptidases - metabolism Serine protease Serine Proteinase Inhibitors - pharmacology Solubility
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