MGMT promoter methylation and correlation with protein expression in primary central nervous system lymphoma

The O 6 -methylguanine-DNA-methyltransferase (MGMT) gene encodes for a DNA repairing enzyme of which silencing by promoter methylation is involved in brain tumorigenesis. MGMT promoter methylation represents a favorable prognostic factor and has been associated with a better response to alkylating a...

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Veröffentlicht in:	Virchows Archiv : an international journal of pathology 2014-11, Vol.465 (5), p.579-586
Hauptverfasser:	Toffolatti, L., Scquizzato, E., Cavallin, S., Canal, F., Scarpa, M., Stefani, P. M., Gherlinzoni, F., Dei Tos, A. P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biomarkers, Tumor - metabolism Brain tumors Central nervous system Central Nervous System Neoplasms - genetics Central Nervous System Neoplasms - metabolism Chemotherapy Correlation coefficient Dacarbazine - analogs & derivatives Dacarbazine - therapeutic use Deoxyribonucleic acid DNA DNA Methylation Female Humans Immunohistochemistry Lymphoma Lymphoma - genetics Lymphoma - metabolism Male Medicine Medicine & Public Health Methylation Middle Aged O-Methylguanine-DNA Methyltransferase - biosynthesis O-Methylguanine-DNA Methyltransferase - genetics Original Article Pathology Promoter Regions, Genetic
Online-Zugang:	Volltext
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