Sustained behavioral effects of lithium exposure during early development in zebrafish: Involvement of the Wnt-β-catenin signaling pathway

Lithium has been the paradigmatic treatment for bipolar disorder since 1950s, offering prophylactic and acute efficacy against maniac and depressive episodes. Its use during early pregnancy and the perinatal period remains controversial due to reports of negative consequences on the newborn includin...

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Veröffentlicht in:	Progress in neuro-psychopharmacology & biological psychiatry 2014-12, Vol.55, p.101-108
Hauptverfasser:	Nery, Laura R., Eltz, Natália S., Martins, Lídia, Guerim, Laura D., Pereira, Talita C., Bogo, Maurício R., Vianna, Monica R.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimanic Agents - toxicity beta Catenin - metabolism Blotting, Western Cadherins - metabolism Danio rerio Dose-Response Relationship, Drug Freshwater Heart Defects, Congenital - chemically induced Kaplan-Meier Estimate Lithium Lithium Chloride - toxicity Motor Activity - physiology N-Cadherin Neurobehavioral effects Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger Tail - abnormalities Wnt Wnt3A Protein - metabolism Zebrafish Zebrafish - growth & development Zebrafish - physiology Zebrafish Proteins - metabolism β-Catenin
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