Fructus Ligustri Lucidi (FLL) ethanol extract increases bone mineral density and improves bone properties in growing female rats
Osteoporosis is a chronic disease affecting millions of people worldwide. It is generally accepted that acquisition of a high peak bone mass (PBM) early in life can reduce the risk of osteoporosis later in life. The aims of this study were to investigate the effects of Fructus Ligustri Lucidi (FLL)...
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| Veröffentlicht in: | Journal of bone and mineral metabolism 2014-11, Vol.32 (6), p.616-626 |
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| creator | Lyu, Ying Feng, Xin Zhao, Pengling Wu, Zhenghao Xu, Hao Fang, Yuehui Hou, Yangfeng Denney, Liya Xu, Yajun Feng, Haotian |
| description | Osteoporosis is a chronic disease affecting millions of people worldwide. It is generally accepted that acquisition of a high peak bone mass (PBM) early in life can reduce the risk of osteoporosis later in life. The aims of this study were to investigate the effects of Fructus Ligustri Lucidi (FLL) ethanol extract on bone mineral density and its mechanical properties in growing female rats and to explore the underlying mechanisms. The rats were given different doses of FLL extract mixed with AIN-93G formula (0.40, 0.65 and 0.90 %), and a group given AIN-93G diet treatment only was used as control. The intervention lasted for 16 weeks until the animals were about 5 months old, the time when the animals almost reach their PBM. Our results showed that FLL treatment increased bone mineral density and improved bone mechanical properties in the growing female rats in a dose-dependent manner. In addition, FLL treatment significantly decreased the serum bone-resorbing marker, CTX-I, while significantly increasing serum 25(OH)D
3
and thereby increasing Ca absorption and Ca retention. Intriguingly, both in vivo and in vitro results demonstrated that FLL treatment could reduce the RANKL/OPG ratio. In conclusion, FLL ethanol extract exerted beneficial effects on peak bone mass acquisition and the improvement of bone mechanical properties by favoring Ca metabolism and decreasing the RANKL/OPG ratio. |
| doi_str_mv | 10.1007/s00774-013-0536-8 |
| format | Article |
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3
and thereby increasing Ca absorption and Ca retention. Intriguingly, both in vivo and in vitro results demonstrated that FLL treatment could reduce the RANKL/OPG ratio. In conclusion, FLL ethanol extract exerted beneficial effects on peak bone mass acquisition and the improvement of bone mechanical properties by favoring Ca metabolism and decreasing the RANKL/OPG ratio.</description><identifier>ISSN: 0914-8779</identifier><identifier>EISSN: 1435-5604</identifier><identifier>DOI: 10.1007/s00774-013-0536-8</identifier><identifier>PMID: 24362453</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Animals ; Bone Density - drug effects ; Bone Resorption - blood ; Bone Resorption - drug therapy ; Calcitriol - blood ; Calcium - blood ; Dose-Response Relationship, Drug ; Ethanol ; Female ; Ligustrum - chemistry ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Original Article ; Orthopedics ; Osteoprotegerin - metabolism ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; RANK Ligand - metabolism ; Rats ; Rats, Sprague-Dawley</subject><ispartof>Journal of bone and mineral metabolism, 2014-11, Vol.32 (6), p.616-626</ispartof><rights>The Japanese Society for Bone and Mineral Research and Springer Japan 2013</rights><rights>The Japanese Society for Bone and Mineral Research and Springer Japan 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-65b4aa8111d96309a66125d62c7f161910516ac25c1955f1b6c767952ab4d6193</citedby><cites>FETCH-LOGICAL-c499t-65b4aa8111d96309a66125d62c7f161910516ac25c1955f1b6c767952ab4d6193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00774-013-0536-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00774-013-0536-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24362453$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lyu, Ying</creatorcontrib><creatorcontrib>Feng, Xin</creatorcontrib><creatorcontrib>Zhao, Pengling</creatorcontrib><creatorcontrib>Wu, Zhenghao</creatorcontrib><creatorcontrib>Xu, Hao</creatorcontrib><creatorcontrib>Fang, Yuehui</creatorcontrib><creatorcontrib>Hou, Yangfeng</creatorcontrib><creatorcontrib>Denney, Liya</creatorcontrib><creatorcontrib>Xu, Yajun</creatorcontrib><creatorcontrib>Feng, Haotian</creatorcontrib><title>Fructus Ligustri Lucidi (FLL) ethanol extract increases bone mineral density and improves bone properties in growing female rats</title><title>Journal of bone and mineral metabolism</title><addtitle>J Bone Miner Metab</addtitle><addtitle>J Bone Miner Metab</addtitle><description>Osteoporosis is a chronic disease affecting millions of people worldwide. It is generally accepted that acquisition of a high peak bone mass (PBM) early in life can reduce the risk of osteoporosis later in life. The aims of this study were to investigate the effects of Fructus Ligustri Lucidi (FLL) ethanol extract on bone mineral density and its mechanical properties in growing female rats and to explore the underlying mechanisms. The rats were given different doses of FLL extract mixed with AIN-93G formula (0.40, 0.65 and 0.90 %), and a group given AIN-93G diet treatment only was used as control. The intervention lasted for 16 weeks until the animals were about 5 months old, the time when the animals almost reach their PBM. Our results showed that FLL treatment increased bone mineral density and improved bone mechanical properties in the growing female rats in a dose-dependent manner. In addition, FLL treatment significantly decreased the serum bone-resorbing marker, CTX-I, while significantly increasing serum 25(OH)D
3
and thereby increasing Ca absorption and Ca retention. Intriguingly, both in vivo and in vitro results demonstrated that FLL treatment could reduce the RANKL/OPG ratio. In conclusion, FLL ethanol extract exerted beneficial effects on peak bone mass acquisition and the improvement of bone mechanical properties by favoring Ca metabolism and decreasing the RANKL/OPG ratio.</description><subject>Animals</subject><subject>Bone Density - drug effects</subject><subject>Bone Resorption - blood</subject><subject>Bone Resorption - drug therapy</subject><subject>Calcitriol - blood</subject><subject>Calcium - blood</subject><subject>Dose-Response Relationship, Drug</subject><subject>Ethanol</subject><subject>Female</subject><subject>Ligustrum - chemistry</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Osteoprotegerin - metabolism</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>RANK Ligand - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>0914-8779</issn><issn>1435-5604</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kU2LFDEQhoMo7rj6A7xIwMt6aE2l89E5yuKo0OBFzyGdrh6zdKfHJK3uzZ9uhtkVEbzkg3rqrYKHkOfAXgNj-k2uhxYNg7ZhslVN94DsQLSykYqJh2THDIim09pckCc53zAGWmp4TC64aBUXst2RX_u0-bJl2ofDlksKtN98GAO92vf9K4rlq4vrTPFnSc4XGqJP6DJmOqwR6RIiJjfTEWMO5Za6ONKwHNP6_Z6o7yOmEuo_RHpI648QD3TCxc1Ikyv5KXk0uTnjs7v7knzZv_t8_aHpP73_eP22b7wwpjRKDsK5DgBGo1pmnFLA5ai41xMoMMAkKOe59GCknGBQXittJHeDGGu9vSRX59y60bcNc7FLyB7n2UVct2xBtZLxjilV0Zf_oDfrlmLdrlJcCs0E6yoFZ8qnNeeEkz2msLh0a4HZkx571mOrHnvSY089L-6St2HB8U_HvY8K8DOQaykeMP01-r-pvwGrTJod</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>Lyu, Ying</creator><creator>Feng, Xin</creator><creator>Zhao, Pengling</creator><creator>Wu, Zhenghao</creator><creator>Xu, Hao</creator><creator>Fang, Yuehui</creator><creator>Hou, Yangfeng</creator><creator>Denney, Liya</creator><creator>Xu, Yajun</creator><creator>Feng, Haotian</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20141101</creationdate><title>Fructus Ligustri Lucidi (FLL) ethanol extract increases bone mineral density and improves bone properties in growing female rats</title><author>Lyu, Ying ; 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It is generally accepted that acquisition of a high peak bone mass (PBM) early in life can reduce the risk of osteoporosis later in life. The aims of this study were to investigate the effects of Fructus Ligustri Lucidi (FLL) ethanol extract on bone mineral density and its mechanical properties in growing female rats and to explore the underlying mechanisms. The rats were given different doses of FLL extract mixed with AIN-93G formula (0.40, 0.65 and 0.90 %), and a group given AIN-93G diet treatment only was used as control. The intervention lasted for 16 weeks until the animals were about 5 months old, the time when the animals almost reach their PBM. Our results showed that FLL treatment increased bone mineral density and improved bone mechanical properties in the growing female rats in a dose-dependent manner. In addition, FLL treatment significantly decreased the serum bone-resorbing marker, CTX-I, while significantly increasing serum 25(OH)D
3
and thereby increasing Ca absorption and Ca retention. Intriguingly, both in vivo and in vitro results demonstrated that FLL treatment could reduce the RANKL/OPG ratio. In conclusion, FLL ethanol extract exerted beneficial effects on peak bone mass acquisition and the improvement of bone mechanical properties by favoring Ca metabolism and decreasing the RANKL/OPG ratio.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>24362453</pmid><doi>10.1007/s00774-013-0536-8</doi><tpages>11</tpages></addata></record> |
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| subjects | Animals Bone Density - drug effects Bone Resorption - blood Bone Resorption - drug therapy Calcitriol - blood Calcium - blood Dose-Response Relationship, Drug Ethanol Female Ligustrum - chemistry Medicine Medicine & Public Health Metabolic Diseases Original Article Orthopedics Osteoprotegerin - metabolism Plant Extracts - chemistry Plant Extracts - pharmacology RANK Ligand - metabolism Rats Rats, Sprague-Dawley |
| title | Fructus Ligustri Lucidi (FLL) ethanol extract increases bone mineral density and improves bone properties in growing female rats |
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