Preclinical development and ocular biodistribution of gemini-DNA nanoparticles after intravitreal and topical administration: Towards non-invasive glaucoma gene therapy

Abstract Gene therapy could offer improvement in the treatment of glaucoma compared to the current standard of lowering intraocular pressure. We have developed and characterized non-viral gemini surfactant-phospholipid nanoparticles (GL-NPs) for intravitreal and topical administration. Optimized GL-...

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Veröffentlicht in:	Nanomedicine 2014-11, Vol.10 (8), p.1637-1647
Hauptverfasser:	Alqawlaq, Samih, MSc, Sivak, Jeremy M., PhD, Huzil, J. Torin, PhD, Ivanova, Marina V., MSc, Flanagan, John G., PhD, Beazely, Michael A., PhD, Foldvari, Marianna, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Animals Eye - metabolism gene delivery Gene Transfer Techniques Genetic Therapy - methods glaucoma Glaucoma - therapy Internal Medicine Male Mice Mice, Inbred C57BL nanoparticles Nanoparticles - chemistry non-viral ocular administration preclinical retina topical
Online-Zugang:	Volltext
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