Synergistic effect of Wnt modulatory small molecules and an osteoinductive ceramic on C2C12 cell osteogenic differentiation

Abstract Although osteoinductive ceramics can induce osteoblast differentiation in vitro and bone regeneration in vivo, their effects rely solely on the limited number of endogenous stem cells. More recently, ceramic carriers seeded with culture-expanded stem cells have been reported as implants cap...

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Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2014-10, Vol.67, p.109-121
Hauptverfasser:	Chen, Sigeng, Ryan, Daniel A, Dwyer, Mary A, Cashman, John R
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Bone Morphogenetic Protein 2 - metabolism C2C12 Calcium Phosphates - pharmacology Cell Differentiation - drug effects Cell differentiation, maturation, development, hematopoiesis Cell Line Cell physiology Ceramics Core Binding Factor Alpha 1 Subunit - metabolism Drug Synergism Fundamental and applied biological sciences. Psychology Humans Mesenchymal stromal cells Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - drug effects Molecular and cellular biology Orthopedics Osteogenesis Osteogenesis - drug effects Skeleton and joints Small molecules Tricalcium phosphate ceramic Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: osteoarticular system, musculoskeletal system Wnt
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