Dexamethasone alters epithelium proliferation and survival and suppresses Wnt/β-catenin signaling in developing cleft palate

► Dexamethasone-induced cleft palate results from unfused palatal shelves. ► Dexamethasone inhibits Wnt/β-catenin pathway in palate development. ► Dexamethasone alters medial edge epithelium proliferation in palate development. ► Dexamethasone reduces epithelium apoptosis to delay the elevation of p...

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Veröffentlicht in:	Food and chemical toxicology 2013-06, Vol.56, p.67-74
Hauptverfasser:	Hu, Xiao, Gao, Jian Hua, Liao, Yun Jun, Tang, Shi Jie, Lu, Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects beta Catenin - antagonists & inhibitors beta Catenin - metabolism Biological and medical sciences Cell apoptosis Cell proliferation Cell Proliferation - drug effects Cell Survival - drug effects Cleft palate Cleft Palate - chemically induced Cleft Palate - embryology Cleft Palate - pathology Dexamethasone Dexamethasone - adverse effects Down-Regulation Embryonic Development - drug effects Epithelium - drug effects Epithelium - embryology Female In Situ Nick-End Labeling Medical sciences Mice Microscopy, Electron, Scanning Toxicology Wnt Signaling Pathway - drug effects Wnt/β-catenin signaling
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