Dexamethasone alters epithelium proliferation and survival and suppresses Wnt/β-catenin signaling in developing cleft palate
► Dexamethasone-induced cleft palate results from unfused palatal shelves. ► Dexamethasone inhibits Wnt/β-catenin pathway in palate development. ► Dexamethasone alters medial edge epithelium proliferation in palate development. ► Dexamethasone reduces epithelium apoptosis to delay the elevation of p...
Gespeichert in:
| Veröffentlicht in: | Food and chemical toxicology 2013-06, Vol.56, p.67-74 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 74 |
|---|---|
| container_issue | |
| container_start_page | 67 |
| container_title | Food and chemical toxicology |
| container_volume | 56 |
| creator | Hu, Xiao Gao, Jian Hua Liao, Yun Jun Tang, Shi Jie Lu, Feng |
| description | ► Dexamethasone-induced cleft palate results from unfused palatal shelves. ► Dexamethasone inhibits Wnt/β-catenin pathway in palate development. ► Dexamethasone alters medial edge epithelium proliferation in palate development. ► Dexamethasone reduces epithelium apoptosis to delay the elevation of palatal shelf.
Dexamethasone (Dex) contributes to a cleft palate, but the cellular and molecular mechanisms responsible for the deleterious effect on the developing palate are unclear. Wnt signaling is a causal mechanism of Dex-induced osteoporosis, so this study was conducted to determine whether Dex-induced cleft palate may result from altered Wnt signaling. Administration of Dex to mice completely inhibited canonical Wnt/β-catenin signaling and altered cell proliferation and apoptosis of the craniofacial epithelium in developing embryos. Thus, downregulated Wnt/β-catenin signaling was associated with Dex-induced cleft palate. Moreover, altered cell fate by Dex responsible for small palates, delaying shelf elevation and unfused palates was a crucial mechanism in cleft palate. Our findings help in elucidating the mechanisms of Dex-induced cleft palate. |
| doi_str_mv | 10.1016/j.fct.2013.02.003 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1635025053</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0278691513001117</els_id><sourcerecordid>1635025053</sourcerecordid><originalsourceid>FETCH-LOGICAL-c416t-c80e13758066384d4b8f14d8b169cc89a1fc456eef893aa9e32d1ebdb38ace773</originalsourceid><addsrcrecordid>eNqFkc1u1DAQxy0EotvCA3BBuSBxSWrH8UfECbV8SZW4gDhaE2fSeuV1gu2syoGX4kF4JrzaBW5wsv7Sb8Yz8yPkGaMNo0xebpvJ5qaljDe0bSjlD8iGacVryQV7SDa0VbqWPRNn5DylLaVUMSUfk7OWd0wyTjfk-zXeww7zHaQ5YAU-Y0wVLi7foXfrrlri7N2EEbKbQwVhrNIa924P_hSWJWJKmKovIV_-_FFbyBhcqJK7DeBduK1KGHGPfl4OyXqccrWAL9wT8mgCn_Dp6b0gn9---XT1vr75-O7D1eub2pY5c201RcaV0FRKrruxG_TEulEPTPbW6h7YZDshESfdc4AeeTsyHMaBa7CoFL8gL499yzZfV0zZ7Fyy6D0EnNdkWDkYbQUV_P8o76RQSoiuoOyI2jinFHEyS3Q7iN8Mo-YgyGxNEWQOggxtTRFUap6f2q_DDsc_Fb-NFODFCYBkwU8RgnXpL6daLVTfF-7VkcNyt73DaJJ1GCyOLmL5dJzdP8b4Bbf4sP4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1346577554</pqid></control><display><type>article</type><title>Dexamethasone alters epithelium proliferation and survival and suppresses Wnt/β-catenin signaling in developing cleft palate</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Hu, Xiao ; Gao, Jian Hua ; Liao, Yun Jun ; Tang, Shi Jie ; Lu, Feng</creator><creatorcontrib>Hu, Xiao ; Gao, Jian Hua ; Liao, Yun Jun ; Tang, Shi Jie ; Lu, Feng</creatorcontrib><description>► Dexamethasone-induced cleft palate results from unfused palatal shelves. ► Dexamethasone inhibits Wnt/β-catenin pathway in palate development. ► Dexamethasone alters medial edge epithelium proliferation in palate development. ► Dexamethasone reduces epithelium apoptosis to delay the elevation of palatal shelf.
Dexamethasone (Dex) contributes to a cleft palate, but the cellular and molecular mechanisms responsible for the deleterious effect on the developing palate are unclear. Wnt signaling is a causal mechanism of Dex-induced osteoporosis, so this study was conducted to determine whether Dex-induced cleft palate may result from altered Wnt signaling. Administration of Dex to mice completely inhibited canonical Wnt/β-catenin signaling and altered cell proliferation and apoptosis of the craniofacial epithelium in developing embryos. Thus, downregulated Wnt/β-catenin signaling was associated with Dex-induced cleft palate. Moreover, altered cell fate by Dex responsible for small palates, delaying shelf elevation and unfused palates was a crucial mechanism in cleft palate. Our findings help in elucidating the mechanisms of Dex-induced cleft palate.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/j.fct.2013.02.003</identifier><identifier>PMID: 23416130</identifier><identifier>CODEN: FCTOD7</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Apoptosis - drug effects ; beta Catenin - antagonists & inhibitors ; beta Catenin - metabolism ; Biological and medical sciences ; Cell apoptosis ; Cell proliferation ; Cell Proliferation - drug effects ; Cell Survival - drug effects ; Cleft palate ; Cleft Palate - chemically induced ; Cleft Palate - embryology ; Cleft Palate - pathology ; Dexamethasone ; Dexamethasone - adverse effects ; Down-Regulation ; Embryonic Development - drug effects ; Epithelium - drug effects ; Epithelium - embryology ; Female ; In Situ Nick-End Labeling ; Medical sciences ; Mice ; Microscopy, Electron, Scanning ; Toxicology ; Wnt Signaling Pathway - drug effects ; Wnt/β-catenin signaling</subject><ispartof>Food and chemical toxicology, 2013-06, Vol.56, p.67-74</ispartof><rights>2013 Elsevier Ltd</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-c80e13758066384d4b8f14d8b169cc89a1fc456eef893aa9e32d1ebdb38ace773</citedby><cites>FETCH-LOGICAL-c416t-c80e13758066384d4b8f14d8b169cc89a1fc456eef893aa9e32d1ebdb38ace773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.fct.2013.02.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27285799$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23416130$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hu, Xiao</creatorcontrib><creatorcontrib>Gao, Jian Hua</creatorcontrib><creatorcontrib>Liao, Yun Jun</creatorcontrib><creatorcontrib>Tang, Shi Jie</creatorcontrib><creatorcontrib>Lu, Feng</creatorcontrib><title>Dexamethasone alters epithelium proliferation and survival and suppresses Wnt/β-catenin signaling in developing cleft palate</title><title>Food and chemical toxicology</title><addtitle>Food Chem Toxicol</addtitle><description>► Dexamethasone-induced cleft palate results from unfused palatal shelves. ► Dexamethasone inhibits Wnt/β-catenin pathway in palate development. ► Dexamethasone alters medial edge epithelium proliferation in palate development. ► Dexamethasone reduces epithelium apoptosis to delay the elevation of palatal shelf.
Dexamethasone (Dex) contributes to a cleft palate, but the cellular and molecular mechanisms responsible for the deleterious effect on the developing palate are unclear. Wnt signaling is a causal mechanism of Dex-induced osteoporosis, so this study was conducted to determine whether Dex-induced cleft palate may result from altered Wnt signaling. Administration of Dex to mice completely inhibited canonical Wnt/β-catenin signaling and altered cell proliferation and apoptosis of the craniofacial epithelium in developing embryos. Thus, downregulated Wnt/β-catenin signaling was associated with Dex-induced cleft palate. Moreover, altered cell fate by Dex responsible for small palates, delaying shelf elevation and unfused palates was a crucial mechanism in cleft palate. Our findings help in elucidating the mechanisms of Dex-induced cleft palate.</description><subject>Animals</subject><subject>Apoptosis - drug effects</subject><subject>beta Catenin - antagonists & inhibitors</subject><subject>beta Catenin - metabolism</subject><subject>Biological and medical sciences</subject><subject>Cell apoptosis</subject><subject>Cell proliferation</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Cleft palate</subject><subject>Cleft Palate - chemically induced</subject><subject>Cleft Palate - embryology</subject><subject>Cleft Palate - pathology</subject><subject>Dexamethasone</subject><subject>Dexamethasone - adverse effects</subject><subject>Down-Regulation</subject><subject>Embryonic Development - drug effects</subject><subject>Epithelium - drug effects</subject><subject>Epithelium - embryology</subject><subject>Female</subject><subject>In Situ Nick-End Labeling</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Microscopy, Electron, Scanning</subject><subject>Toxicology</subject><subject>Wnt Signaling Pathway - drug effects</subject><subject>Wnt/β-catenin signaling</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAQxy0EotvCA3BBuSBxSWrH8UfECbV8SZW4gDhaE2fSeuV1gu2syoGX4kF4JrzaBW5wsv7Sb8Yz8yPkGaMNo0xebpvJ5qaljDe0bSjlD8iGacVryQV7SDa0VbqWPRNn5DylLaVUMSUfk7OWd0wyTjfk-zXeww7zHaQ5YAU-Y0wVLi7foXfrrlri7N2EEbKbQwVhrNIa924P_hSWJWJKmKovIV_-_FFbyBhcqJK7DeBduK1KGHGPfl4OyXqccrWAL9wT8mgCn_Dp6b0gn9---XT1vr75-O7D1eub2pY5c201RcaV0FRKrruxG_TEulEPTPbW6h7YZDshESfdc4AeeTsyHMaBa7CoFL8gL499yzZfV0zZ7Fyy6D0EnNdkWDkYbQUV_P8o76RQSoiuoOyI2jinFHEyS3Q7iN8Mo-YgyGxNEWQOggxtTRFUap6f2q_DDsc_Fb-NFODFCYBkwU8RgnXpL6daLVTfF-7VkcNyt73DaJJ1GCyOLmL5dJzdP8b4Bbf4sP4</recordid><startdate>20130601</startdate><enddate>20130601</enddate><creator>Hu, Xiao</creator><creator>Gao, Jian Hua</creator><creator>Liao, Yun Jun</creator><creator>Tang, Shi Jie</creator><creator>Lu, Feng</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20130601</creationdate><title>Dexamethasone alters epithelium proliferation and survival and suppresses Wnt/β-catenin signaling in developing cleft palate</title><author>Hu, Xiao ; Gao, Jian Hua ; Liao, Yun Jun ; Tang, Shi Jie ; Lu, Feng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-c80e13758066384d4b8f14d8b169cc89a1fc456eef893aa9e32d1ebdb38ace773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Apoptosis - drug effects</topic><topic>beta Catenin - antagonists & inhibitors</topic><topic>beta Catenin - metabolism</topic><topic>Biological and medical sciences</topic><topic>Cell apoptosis</topic><topic>Cell proliferation</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Cleft palate</topic><topic>Cleft Palate - chemically induced</topic><topic>Cleft Palate - embryology</topic><topic>Cleft Palate - pathology</topic><topic>Dexamethasone</topic><topic>Dexamethasone - adverse effects</topic><topic>Down-Regulation</topic><topic>Embryonic Development - drug effects</topic><topic>Epithelium - drug effects</topic><topic>Epithelium - embryology</topic><topic>Female</topic><topic>In Situ Nick-End Labeling</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Microscopy, Electron, Scanning</topic><topic>Toxicology</topic><topic>Wnt Signaling Pathway - drug effects</topic><topic>Wnt/β-catenin signaling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hu, Xiao</creatorcontrib><creatorcontrib>Gao, Jian Hua</creatorcontrib><creatorcontrib>Liao, Yun Jun</creatorcontrib><creatorcontrib>Tang, Shi Jie</creatorcontrib><creatorcontrib>Lu, Feng</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, Xiao</au><au>Gao, Jian Hua</au><au>Liao, Yun Jun</au><au>Tang, Shi Jie</au><au>Lu, Feng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dexamethasone alters epithelium proliferation and survival and suppresses Wnt/β-catenin signaling in developing cleft palate</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>2013-06-01</date><risdate>2013</risdate><volume>56</volume><spage>67</spage><epage>74</epage><pages>67-74</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><abstract>► Dexamethasone-induced cleft palate results from unfused palatal shelves. ► Dexamethasone inhibits Wnt/β-catenin pathway in palate development. ► Dexamethasone alters medial edge epithelium proliferation in palate development. ► Dexamethasone reduces epithelium apoptosis to delay the elevation of palatal shelf.
Dexamethasone (Dex) contributes to a cleft palate, but the cellular and molecular mechanisms responsible for the deleterious effect on the developing palate are unclear. Wnt signaling is a causal mechanism of Dex-induced osteoporosis, so this study was conducted to determine whether Dex-induced cleft palate may result from altered Wnt signaling. Administration of Dex to mice completely inhibited canonical Wnt/β-catenin signaling and altered cell proliferation and apoptosis of the craniofacial epithelium in developing embryos. Thus, downregulated Wnt/β-catenin signaling was associated with Dex-induced cleft palate. Moreover, altered cell fate by Dex responsible for small palates, delaying shelf elevation and unfused palates was a crucial mechanism in cleft palate. Our findings help in elucidating the mechanisms of Dex-induced cleft palate.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>23416130</pmid><doi>10.1016/j.fct.2013.02.003</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0278-6915 |
| ispartof | Food and chemical toxicology, 2013-06, Vol.56, p.67-74 |
| issn | 0278-6915 1873-6351 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1635025053 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Apoptosis - drug effects beta Catenin - antagonists & inhibitors beta Catenin - metabolism Biological and medical sciences Cell apoptosis Cell proliferation Cell Proliferation - drug effects Cell Survival - drug effects Cleft palate Cleft Palate - chemically induced Cleft Palate - embryology Cleft Palate - pathology Dexamethasone Dexamethasone - adverse effects Down-Regulation Embryonic Development - drug effects Epithelium - drug effects Epithelium - embryology Female In Situ Nick-End Labeling Medical sciences Mice Microscopy, Electron, Scanning Toxicology Wnt Signaling Pathway - drug effects Wnt/β-catenin signaling |
| title | Dexamethasone alters epithelium proliferation and survival and suppresses Wnt/β-catenin signaling in developing cleft palate |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T15%3A23%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dexamethasone%20alters%20epithelium%20proliferation%20and%20survival%20and%20suppresses%20Wnt/%CE%B2-catenin%20signaling%20in%20developing%20cleft%20palate&rft.jtitle=Food%20and%20chemical%20toxicology&rft.au=Hu,%20Xiao&rft.date=2013-06-01&rft.volume=56&rft.spage=67&rft.epage=74&rft.pages=67-74&rft.issn=0278-6915&rft.eissn=1873-6351&rft.coden=FCTOD7&rft_id=info:doi/10.1016/j.fct.2013.02.003&rft_dat=%3Cproquest_cross%3E1635025053%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1346577554&rft_id=info:pmid/23416130&rft_els_id=S0278691513001117&rfr_iscdi=true |