CIZ1, a p21Cip1/Waf1-interacting protein, functions as a tumor suppressor in vivo

•Ciz1-deficient (Ciz1−/−) mouse embryonic fibroblasts (MEFs) did not show defects in cell cycle status, cell growth, and DNA damage response.•Ciz1−/− MEFs were sensitive to replication stress and susceptible to cellular transformation.•Ciz1−/− mice developed leukemias by retroviral insertional mutag...

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Veröffentlicht in:	FEBS letters 2013-05, Vol.587 (10), p.1529-1535
Hauptverfasser:	Nishibe, Rio, Watanabe, Wataru, Ueda, Takeshi, Yamasaki, Norimasa, Koller, Richard, Wolff, Linda, Honda, Zen-ichiro, Ohtsubo, Motoaki, Honda, Hiroaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ataxia Telangiectasia Mutated Proteins Cell Cycle - genetics Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Proliferation Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cells, Cultured CIZ1 (Cip1 interacting zinc finger protein 1) Cyclin-Dependent Kinase Inhibitor p21 - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Embryo, Mammalian - cytology Fibroblasts - metabolism Fibroblasts - physiology Mice Mice, Knockout Models, Biological Nuclear Proteins - genetics Nuclear Proteins - metabolism Nuclear Proteins - physiology p21Cip1/Waf1 Protein Binding Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Tumor Suppressor Proteins - physiology Tumorigenesis
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